Isonicotinamide
- CAS No.
- 1453-82-3
- Chemical Name:
- Isonicotinamide
- Synonyms
- PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
- CBNumber:
- CB8259608
- Molecular Formula:
- C6H6N2O
- Molecular Weight:
- 122.12
- MOL File:
- 1453-82-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/18 8:51:57
| Melting point | 155-157 °C(lit.) |
|---|---|
| Boiling point | 227.52°C (rough estimate) |
| Density | 1.2236 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pK1: 3.61(+1) (20°C) |
| color | White to Off-White |
| Water Solubility | 191.7 g/L (37 ºC) |
| BRN | 2173 |
| LogP | -0.28 |
| CAS DataBase Reference | 1453-82-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Pyridinecarboxamide(1453-82-3) |
| EPA Substance Registry System | Isonicotinamide (1453-82-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NR9500000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
Isonicotinamide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I17451 | Isonicotinamide ReagentPlus?, 99% | 1453-82-3 | 25G | ₹2890.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I17451 | Isonicotinamide ReagentPlus?, 99% | 1453-82-3 | 100G | ₹3983.6 | 2022-06-14 | Buy |
| ALFA India | ALF-A18190-36 | Isonicotinamide, 99% | 1453-82-3 | 500g | ₹11389 | 2022-05-26 | Buy |
| ALFA India | ALF-A18190-30 | Isonicotinamide, 99% | 1453-82-3 | 250g | ₹9636 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0135 | Isonicotinamide | 1453-82-3 | 25G | ₹2400 | 2022-05-26 | Buy |
Isonicotinamide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
Application
Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.
Definition
ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.
Preparation
synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.
Purification Methods
Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]
Isonicotinamide Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Triveni Interchem Private Limited | +91-02606618618 +91-7574814001 | Gujarat, India | 42 | 58 | Inquiry |
| Amsal Chem Private Limited | +91-2222050500 +91-2222050500 | Maharashtra, India | 15 | 58 | Inquiry |
| Resonance Specialties Limited | +91-2262106053 +91-2268572824 | Maharashtra, India | 21 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Quiver Technologies | 08048371749Ext 307 | Hyderabad, India | 169 | 58 | Inquiry |
| Amsal Chem Private Limited | +91-(22)-2205 0500 | New Delhi, India | 11 | 58 | Inquiry |
| Chemland Ind | 08046075772 | Gujarat, India | 95 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |