Isonipecotamide
- CAS No.
- 39546-32-2
- Chemical Name:
- Isonipecotamide
- Synonyms
- PIPERIDINE-4-CARBALDEHYDE;PIPERIDINE-4-CARBOXAMIDE;ISONIPECOTAMIDE;4-PIPERIDINECARBOXAMIDE;Isonipectoamide;Isonepicotamide;Isonipecotinamide;Isonipecotamide>TIMTEC-BB SBB004237;Isonipecotamide,98%
- CBNumber:
- CB3411759
- Molecular Formula:
- C6H12N2O
- Molecular Weight:
- 128.17
- MOL File:
- 39546-32-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/11 19:18:13
| Melting point | 145-148 °C(lit.) |
|---|---|
| Boiling point | 237.61°C (rough estimate) |
| Density | 1.0754 (rough estimate) |
| refractive index | 1.4880 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 16.48±0.20(Predicted) |
| color | White to light yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| BRN | 112554 |
| Stability | Hygroscopic |
| InChIKey | DPBWFNDFMCCGGJ-UHFFFAOYSA-N |
| LogP | -0.88 |
| CAS DataBase Reference | 39546-32-2(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Piperidinecarboxamide (39546-32-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Isonipecotamide price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I17907 | 4-Piperidinecarboxamide 97% | 39546-32-2 | 25G | ₹3907.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I17907 | 4-Piperidinecarboxamide 97% | 39546-32-2 | 100G | ₹9883.23 | 2022-06-14 | Buy |
| ALFA India | ALF-A13442-30 | Isonipecotamide, 98% | 39546-32-2 | 250g | ₹22718 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0255 | Isonipecotamide min. 98.0 % | 39546-32-2 | 25G | ₹3300 | 2022-05-26 | Buy |
| ALFA India | ALF-A13442-18 | Isonipecotamide, 98% | 39546-32-2 | 50g | ₹5882 | 2022-05-26 | Buy |
Isonipecotamide Chemical Properties,Uses,Production
Chemical Properties
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Uses
Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.
Application
Isonipecotamide is an important substrate for organic synthesis reactions and can be used to prepare a wide range of inhibitors:
(1) Dual inhibitors of thrombin and cholinesterase with therapeutic potential for Alzheimer's disease[1].
(2) 5-HT receptor inhibitors, based on Isonipecotamide synthesised piperidine carboxamide derivatives showing signs of decreasing 5-HT levels alone while increasing dopamine levels, with antidepressant drug effects[2].
(3) Reversible inhibitors of coagulation factor Xa (fXa) and thrombin (thr) (cmpds 1-3), which have the ability to impede the infection of VERO cells with SARS-CoV-2, with cmpds3 showing a significant inhibitory effect on SARS-CoV-2 infection (~30%) at lower concentrations (3-50 μM)[3].
References
[1] ROSA PURGATORIO. First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.[J]. Molecules, 2021. DOI:10.3390/molecules26175208.
[2] SHAMIM AKHTAR. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.[J]. Pakistan journal of pharmaceutical sciences, 2012.
[3] FLAVIO DE MAIO. Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection.[J]. Viruses-Basel, 2022. DOI:10.3390/v14081730.
Isonipecotamide Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | Rajasthan, India | 145 | 58 | Inquiry |
| EPOCH LABS | +91-7702174901 +91-9515109812 | Hyderabad, India | 68 | 58 | Inquiry |
| A.R. LIFE SCIENCES PVT. LTD. | +91-914040267679 +91-8519993257 | Hyderabad, India | 100 | 58 | Inquiry |
| SSM LABS | +91-7386809859 +91-9963470802 | Telangana, India | 15 | 58 | Inquiry |
| Aether Industries Limited | +91-261-6603130 +91-2616603130 | Gujarat, India | 145 | 58 | Inquiry |
| Vepan Pharmatech Pvt Ltd | +91-9908788828 +91-9966094448 | Telangana, India | 72 | 58 | Inquiry |
| sgtlifesciences | +91-9866957562 +91-9866957562 | Telangana, India | 90 | 58 | Inquiry |
| Radison Labs Private Limited | +91-7337551966 +91-7337551966 | Hyderabad, India | 58 | 58 | Inquiry |
| ZunaChem Pvt Ltd | +91-7337409191 +91-7093354085 | Hyderabad, India | 43 | 58 | Inquiry |
| Bharavi Laboratories (P) Ltd. | 91 80 2666 7742 | New Delhi, India | 359 | 54 | Inquiry |
| Supplier | Advantage |
|---|---|
| Terma Medicare India Pvt.,Ltd | 58 |
| EPOCH LABS | 58 |
| A.R. LIFE SCIENCES PVT. LTD. | 58 |
| SSM LABS | 58 |
| Aether Industries Limited | 58 |
| Vepan Pharmatech Pvt Ltd | 58 |
| sgtlifesciences | 58 |
| Radison Labs Private Limited | 58 |
| ZunaChem Pvt Ltd | 58 |
| Bharavi Laboratories (P) Ltd. | 54 |
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