Nicotinamide
- CAS No.
- 98-92-0
- Chemical Name:
- Nicotinamide
- Synonyms
- NIACINAMIDE;VITAMIN B3;PYRIDINE-3-CARBOXAMIDE;Nicotinamid;3-PYRIDINECARBOXAMIDE;Niaciamide;NICOTINIC ACID AMIDE;Dipigyl;Nicotamide;NicotinamideB.P.,U.S.P.
- CBNumber:
- CB1130111
- Molecular Formula:
- C6H6N2O
- Molecular Weight:
- 122.12
- MOL File:
- 98-92-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/11 17:04:31
| Melting point | 128-131 °C(lit.) |
|---|---|
| Boiling point | 150-160 °C |
| Density | 1.40 |
| vapor density | 4.22 (vs air) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4660 (estimate) |
| Flash point | 182 °C |
| storage temp. | 2-8°C |
| solubility | 691g/l |
| pka | 3.3(at 20℃) |
| form | powder |
| color | white |
| PH | 6.0-7.5 (50g/l, H2O, 20℃) |
| Odor | Odorless |
| PH Range | 9 |
| Water Solubility | 1000 g/L (20 ºC) |
| Decomposition | >=200 °C |
| Merck | 14,6523 |
| BRN | 383619 |
| BCS Class | 1 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| LogP | -0.38 at 21℃ |
| CAS DataBase Reference | 98-92-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Niacinamide(98-92-0) |
| EPA Substance Registry System | Nicotinamide (98-92-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi,T,F | |||||||||
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-37/39-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | QS3675000 | |||||||||
| F | 8 | |||||||||
| Autoignition Temperature | 480 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29362990 | |||||||||
| Toxicity | LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson) | |||||||||
| NFPA 704 |
|
Nicotinamide price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V-016 | Nicotinamide (Vitamin B3) solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 98-92-0 | 1ML | ₹6917.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N3376 | Nicotinamide ≥98% (HPLC), powder | 98-92-0 | 100G | ₹2457.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1033 | Niacinamide Pharmaceutical Secondary Standard; Certified Reference Material | 98-92-0 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N3376 | Nicotinamide ≥98% (HPLC), powder | 98-92-0 | 500G | ₹7133.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N5535 | Niacinamide meets USP testing specifications | 98-92-0 | 100G | ₹3723.8 | 2022-06-14 | Buy |
Nicotinamide Chemical Properties,Uses,Production
Description
A white, crystalline powder. It is odorless or nearly so, and has a bitter taste. Its solutions are neutral to litmus. One g dissolves in about 1 mL of water, in about 1.5 mL of alcohol, and in about 10 mL of glycerin.
Chemical Properties
Niacinamide (Nicotinamide) is a white crystalline powder or forms colorless needle-like crystals.
Uses
Niacinamide is a nutrient and dietary supplement that is an available form of niacin. Nicotinic acid is pyridine beta-carboxylic acid and nicotinamide, which is another term for niacinamide, is the corresponding amide. It is a powder of good water solubility, having a solubility of 1 g in 1 ml of water. Unlike niacin, it has a bitter taste; the taste is masked in the encapsulated form. Used in fortification of cereals, snack foods, and powdered beverages. niacinamide is used as a skin stimulant and skin smoother. Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics.
Definition
ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
benefits
Niacinamide is a multipurpose skin care ingredient. It helps build keratin, a protein that maintains skin health.
1. Niacinamide may enhance the function of skin’s lipid barrier (a layer of water and oil that protects your skin). This helps lock moisture in and keep pollutants or other potential irritants out.
2. Niacinamide has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema. It can also soothe irritation caused by strong exfoliants like retinol or glycolic acid.
3. Niacinamide may help minimize pore's appearance by helping keep your skin smooth and clear. It also may help regulate the amount of oil your glands produce, which can prevent breakouts and clogged pores.
4. Oral nicotinamide supplements may help prevent new skin cancer or precancerous spots from developing in some people.
5. Some research suggests skin care formulas with 5% niacinamide can also help lighten dark spots.
General Description
Vitamin B3 was formerly called nicotinic acid; however, the term niacin is now preferred to avoid any confusion with the alkaloid, nicotine. Niacinamide, also known as nicotinamide, refers to the amide derivative of niacin that is equivalent in vitamin activity. Some texts use niacin to refer to nicotinic acid, niacinamide, and any derivatives with vitamin activity comparable to niacin. Furthermore, research and chemistry-based resources use the terms nicotinic acid and nicotinamide; whereas pharmacy resources use niacin and niacinamide.
Air & Water Reactions
Water soluble.
Reactivity Profile
An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Clinical Use
Niacin is used in the treatment of niacin deficiency, which is referred to as pellagra (from the Italian, pelle for “skin” and agra for “dry”). The major systems affected are the gastrointestinal tract (diarrhea, enteritis and stomatitis), the skin (dermatitis), and the CNS (generalized neurological deficits including dementia). Pellagra has become a rare condition in the United States and other countries that require or encourage enrichment of wheat flour or fortification of cereals with niacin. Because the nucleotide form can be synthesized in vivo from tryptophan, pellagra is most often seen in areas where the diet is deficient in both niacin and tryptophan. Typically, maize (corn)-based diets meet this criteria. Niacin deficiency can also result from diarrhea, cirrhosis, alcoholism, or Hartnup disease. It is interesting that niacin deficiency can also, rarely, result from vitamin B6 deficiency (see Vitamin B6 section). Niacin, but not niacinamide, is also one of the few vitamins that are useful in the treatment of diseases unrelated to deficiencies.
Safety Profile
Nicotinamide is a safe and inexpensive compound with negligible side effects. It is well tolerated even in doses of 1g/day to 3g/day.There are no reports of teratogenicity with nicotinamide. Minor side effects include nausea, vomiting, headache, fatigue. It does not cause vasodilatory side effects like flushing, alteration in blood pressure, body temperature or pulse as seen with niacin.In topical formulation, it does not cause skin irritation, photosensitization in concentrations of 0.0001% to 4%.
Potential Exposure
Used as a dietary supplement and food additive.
Metabolism
Nicotinamide is ingested in food as part of pyridine nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in plant and animal tissues. After the co?enzymes have separated, nicotinamide is absorbed almost completely in the small intestine. After absorption, nicotinamide is stored as NAD in the liver and excretion occurs via kidneys. Tryptophan is converted to nicotinamide through kynurenine?anthranilate pathway in the liver. Tryptophan can thus satisfy the requirement for dietary nicotinic acid.
Purification Methods
Crystallise niacin from *benzene. It has solubility in g/ml: H2O (1), EtOH (0.7) and glycerol (0.1). [Methods in Enzymology 66 23 1980, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 83 1971, Beilstein 22 III/IV 389, 22/2 V 80.]
Incompatibilities
Combustible solid; dust may form explosive mixture with air. Amides are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Nicotinamide Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| MOLECRAFT LIFE SCIENCES PVT LTD | +91 9581188881 | Telangana, India | 189 | 58 | Inquiry |
| Island Veer Chemie Pvt Ltd | +917093280665 | Telangana, India | 32 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
| Covalent Incorporation | +91-9033666099 +91-9033666099 | Gujarat, India | 50 | 58 | Inquiry |
| Ions Pharma | +912266707500 | Maharashtra, India | 89 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| THE MOLECULEZ | 58 |
| MOLECRAFT LIFE SCIENCES PVT LTD | 58 |
| Island Veer Chemie Pvt Ltd | 58 |
| AnalyticsStanza Inc | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| JSK Chemicals | 58 |
| Meenaakshi Molecules Pvt Ltd | 58 |
| Covalent Incorporation | 58 |
| Ions Pharma | 58 |
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