Procaine penicillin G
- CAS No.
- 54-35-3
- Chemical Name:
- Procaine penicillin G
- Synonyms
- PENICILLIN G PROCAINE;PROCAINE BENZYLPENICILLIN;benzylpenicillin procaine;duphapen;depocillin;hostacillin;hydracillin;rocaine penicillin;Procain-Penicillin;Procain Penicillin G
- CBNumber:
- CB0731029
- Molecular Formula:
- C29H38N4O6S
- Molecular Weight:
- 570.7
- MOL File:
- 54-35-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/29 22:41:02
| Melting point | 129-130 °C |
|---|---|
| Density | 1.1335 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 100 mg/mL (175.22 mM);Ethanol: 20 mg/mL (35.04 mM) |
| Water Solubility | Water: 10 mg/mL (17.52 mM) |
| CAS DataBase Reference | 54-35-3 |
| EPA Substance Registry System | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) (54-35-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 orl-rat: >2 g/kg ABANAE 3,534,55/56 |
Procaine penicillin G Chemical Properties,Uses,Production
Chemical Properties
White, fine crystals or powder; odorless; relatively stable to air and light; solutions dextroro- tatory. Sparingly soluble in water; slightly soluble in alcohol; fairly soluble in chloroform.
Uses
Antibacterial.
General Description
The first widely used amine salt of penicillin G wasmade with procaine. Penicillin G procaine (Crysticillin,Duracillin, Wycillin) can be made readily from penicillin Gsodium by treatment with procaine hydrochloride. This saltis considerably less soluble in water than the alkali metalsalts, requiring about 250 mL to dissolve 1 g. Free penicillinis released only as the compound dissolves and dissociates.It has an activity of 1,009 units/mg. A large number ofpreparations for injection of penicillin G procaine are commerciallyavailable. Most of these are either suspensions inwater to which a suitable dispersing or suspending agent, a buffer, and a preservative have been added or suspensions inpeanut oil or sesame oil that have been gelled by theaddition of 2% aluminum monostearate. Some commercialproducts are mixtures of penicillin G potassium or sodiumwith penicillin G procaine; the water-soluble salt providesrapid development of a high plasma concentration of penicillin,and the insoluble salt prolongs the duration of effect.
Safety Profile
Moderately toxic by intraperitoneal and intramuscular routes. Slightly toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx, and SOx.
Procaine penicillin G Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Tirupati Engineers | 08805575292 | Pune, India | 1 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1142 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
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