Penicillin V potassium salt
- CAS No.
- 132-98-9
- Chemical Name:
- Penicillin V potassium salt
- Synonyms
- pvk;PENICILLIN V;PENICILLIN V POTASSIUM;vk;PHENOXYMETHYLPENICILLIN POTASSIUM;dov-k;dqv-k;vepen;icipen;orapen
- CBNumber:
- CB1713170
- Molecular Formula:
- C16H17KN2O5S
- Molecular Weight:
- 388.48
- MOL File:
- 132-98-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/15 19:00:21
| Melting point | 197-202°C |
|---|---|
| alpha | D25 +223° (c = 0.2) |
| Density | 1.40 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent). |
| form | Solid |
| color | Sol in water |
| Water Solubility | Soluble in water, dimethyl sulfoxide, and methanol. |
| BRN | 3899451 |
| BCS Class | 1 (CLogP), 3 (LogP) |
| Stability | Hygroscopic |
| InChIKey | HCTVWSOKIJULET-LQDWTQKMSA-M |
| CAS DataBase Reference | 132-98-9(CAS DataBase Reference) |
| EPA Substance Registry System | Penicillin V Potassium (132-98-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H334 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P304+P340+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-42/43 | |||||||||
| Safety Statements | 22-26-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XH9275000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29411099 | |||||||||
| Toxicity | LD50 orally in rats: >1040 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Penicillin V potassium salt Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Penicillin antibacterial.
Application
Phenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira.
General Description
Odorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.
Air & Water Reactions
Water soluble.
Reactivity Profile
Penicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.
Fire Hazard
Flash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.
Safety Profile
Moderately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used
Penicillin V potassium salt Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Vitus Global Inc | 91-11-40516279 | Delhi, India | 91 | 58 | Inquiry |
| Anantco Enterprises Pvt., Ltd. | 91-22-67685000 | Maharashtra, India | 71 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hindchem Corporation | 08048976759 | Mumbai, India | 118 | 58 | Inquiry |
| Dac Pharma Merchant | 91-120-4279616 | Uttar Pradesh, India | 47 | 58 | Inquiry |