ChemicalBook > Product Catalog >API >Circulatory system drugs >Antihypertensive drugs >Losartan potassium
Losartan potassium
- CAS No.
- 124750-99-8
- Chemical Name:
- Losartan potassium
- Synonyms
- COZAAR;Losartan Pottasium;DUP 753;LOSARTAN POTASSIUM SALT;MK-95;MK 954;mk-0954;Aradois;l-158086;dupont753
- CBNumber:
- CB1442564
- Molecular Formula:
- C22H23ClKN6O
- Molecular Weight:
- 462.01
- MOL File:
- 124750-99-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/28 8:57:53
| Melting point | 263-265°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Freely soluble in water and in methanol, slightly soluble in acetonitrile. |
| form | powder or crystals |
| color | Off-white |
| Merck | 14,5583 |
| BRN | 5845770 |
| BCS Class | 1 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChI | InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1 |
| InChIKey | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
| SMILES | C1(C=CC=CC=1C1=CC=C(CN2C(CO)=C(Cl)N=C2CCCC)C=C1)C1=NN=NN1[K] |
| CAS DataBase Reference | 124750-99-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI6755100 | |||||||||
| HS Code | 2933290000 | |||||||||
| NFPA 704 |
|
Losartan potassium price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1602 | Losartan Potassium Pharmaceutical Secondary Standard; Certified Reference Material | 124750-99-8 | 1G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 61188 | Losartan potassium analytical standard | 124750-99-8 | 100MG | ₹19658.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | L0232 | Losartan Potassium | 124750-99-8 | 5G | ₹10800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | L0232 | Losartan Potassium | 124750-99-8 | 25G | ₹22100 | 2022-05-26 | Buy |
Losartan potassium Chemical Properties,Uses,Production
Description
Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.
Chemical Properties
White to Off-White Crystalline Powder
Uses
A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Biological Activity
Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.
Losartan potassium Preparation Products And Raw materials
Raw materials
Thionyl chloride
4′-Methylbiphenyl-2-carboxylic acid methyl ester
2-n-Butyl-4-Chloro-5-Hydroxymethyl Imidazole
Potassium hydroxide
Sodium azide
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Global( 830)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| TAGOOR LABORATORIES PVT LTD | +919700187008 | AndhraPradesh, India | 93 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| Vijayasri Organics Private Limited | +91-9848990113 +91-9848990113 | Telangana, India | 43 | 58 | Inquiry |
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Jigs Chemical ltd | 58 |
| TAGOOR LABORATORIES PVT LTD | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| AVD pharmaceuticals Pvt Ltd | 58 |
| Vijayasri Organics Private Limited | 58 |
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| S.V ENTERPRISES | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| Gonane Pharma | 58 |
Related articles
- Losartan Potassium: Therapeutic Insights and Pharmacokinetics
- Losartan Potassium effectively reduces blood pressure by blocking angiotensin II receptors, with its active metabolite enhanci....
- Jun 28，2024
124750-99-8(Losartan potassium)Related Search:
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2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL
2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt
2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT
LOSARTAN MONOPOTASSIUM SALT
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Losartan Potassium (250 mg)
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Losartan PotassiuM/Losartan K
Losartan PotassiuM (DuP 753)
2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, potassium salt (1:1)
Losartan Potassium (150 mg)
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potassium [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanolate
potassium [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanolate
potassium [2-butyl-5-chloro-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]imidazol-4-yl]methanolate
dupont753
l-158086
mk-0954
thanolpotassium
2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-imidazole-5-methanol,monopotassium salt
MK-95
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2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-
Aradois
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Losartan potassium 124750-99-8
Losartan potassium Solution, 100ppm
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Losartan potassium CRS
LosartanPotassium>
Losartan Potassium RS
(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol, potassium salt
Losartan potassium USP/EP/BP
Losartan Potassium- IP/USP
Losartan potassiumQ: What is
Losartan potassium Q: What is the CAS Number of
Losartan potassium Q: What is the storage condition of
Losartan potassium Q: What are the applications of
Losartan potassium
Losartan potassium (Y0001062)
Losartan Potassium (1370462)
COZAAR
Losartan Pottasium
Chlorine sand potassium
LOSARTAN POTASSIUM SALT
DUP 753
COZAAR Powder USP Standard
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt (1:1)
Losartan Potassium IP/BP/Ph. Eur /USP
Losartan Potassium
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-
yl]methyl]-1H-imidazole-5-methanol monopotassium salt