눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P312
불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P403+P233
용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
NFPA 704
0
4
0
Losartan potassium C화학적 특성, 용도, 생산
개요
Losartan potassium is the first potent and selective non-peptide angiotensin II
(AT II) AT1 receptor antagonist introduced to the market as a once-daily oral
antihypertensive. It is efficacious and long lasting in controlling blood pressure in
spontaneous hypertensive rats, in patients with essential hypertension in addition to
those patients with renal impairment. Since losartan functions by competitive
antagonism at the level of receptor, which represents the most direct way of
selectively inhibiting the renin-angiotensin system (RAS) independent of the source
of AT II, its use has been reported to be free of the coughing side effect exhibited by
the ACE inhibitors. In contrast to calcium channel blockers, losartan does not
appear to cause ankle edema, headache and tachycardia. It is also reported to be in
clinical trials for the treatment of heart failure. Other reports indicate that losartan
may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative
response of the vascular wall after coronary angioplasty and surgery.
화학적 성질
White to Off-White Crystalline Powder
용도
A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
생물학적 활성
Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.