Tetrazole
- CAS No.
- 288-94-8
- Chemical Name:
- Tetrazole
- Synonyms
- 1H-TETRAZOLE;2H-TETRAZOLE;1H-1,2,3,4-TETRAAZOLE;TETRAZOLE;1tetrazole;1H-Tetraazole;Tetrazole,98%;1H tetrazolium;1,2,3,4-tetrazole;1H-Tetrazole,99+%
- CBNumber:
- CB4230898
- Molecular Formula:
- CH2N4
- Molecular Weight:
- 70.05
- MOL File:
- 288-94-8.mol
- Modify Date:
- 2024/3/13 16:52:01
| Melting point | 156-158°C |
|---|---|
| Boiling point | 220℃ |
| Density | 0.798 g/mL at 20 °C |
| refractive index |
n |
| RTECS | UW7370000 |
| Flash point | 5 °C |
| storage temp. | Room temperature. |
| solubility | DMSO, Methanol |
| form | Liquid |
| pka | 4.9(at 25℃) |
| color | Cream to orange |
| Water Solubility | Soluble |
| Decomposition | 220°C |
| BRN | 105799 |
| Stability | Stable at RT |
| InChIKey | KJUGUADJHNHALS-UHFFFAOYSA-N |
| CAS DataBase Reference | 288-94-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Tetrazole(288-94-8) |
| EPA Substance Registry System | 1H-Tetrazole (288-94-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H303-H312-H225-H302-H319-H332 |
| Precautionary statements | P210-P305+P351+P338-P261-P280-P303+P361+P353-P501a |
| Hazard Codes | F,Xn,E |
| Risk Statements | 11-20/21/22-36-5-4 |
| Safety Statements | 16-26-36-36/37-35-15 |
| RIDADR | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| F | 3-4.15-10 |
| HazardClass | 4.1 |
| PackingGroup | III |
| HS Code | 29339900 |
Tetrazole price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 88185 | Tetrazole solution suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45?M in acetonitrile | 288-94-8 | 100ML | ₹10786.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 88185 | Tetrazole solution suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45?M in acetonitrile | 288-94-8 | 500ML | ₹33968.2 | 2022-06-14 | Buy |
| ottokemi | T 1526 | Tetrazole 3 to 4 wt.% solution in acetonitrile | 288-94-8 | 100mL | ₹9171 | 2022-05-26 | Buy |
| ottokemi | T 1526 | Tetrazole 3 to 4 wt.% solution in acetonitrile | 288-94-8 | 500mL | ₹36099 | 2022-05-26 | Buy |
| ottokemi | T 1525 | 1H-Tetrazole 99% | 288-94-8 | 1gm | ₹270 | 2022-05-26 | Buy |
Tetrazole Chemical Properties,Uses,Production
Chemical Properties
white crystals or crystalline powder
Uses
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
Definition
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
Application
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
Preparation
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
General Description
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
Health Hazard
Fire may produce irritating, corrosive and/or toxic gases.
Fire Hazard
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
Purification Methods
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]
Tetrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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