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Irbesartan

CAS No.: 138402-11-6

Chemical Name:: Irbesartan

Synonyms: AVAPRO;Lrbesartan;Irbesatan;Irbesartan Impurity 1;3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;APROVEL;CS-1097;SR-47436;Irbesarta;BMS-186295

CBNumber:: CB4454663

Molecular Formula:: C25H28N6O

Molecular Weight:: 428.53

MOL File:: 138402-11-6.mol

MSDS File:: SDS

Modify Date:: 2024/7/24 17:31:20

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Irbesartan Properties

Melting point	180-181°C
Boiling point	648.6±65.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >25mg/mL
pka	4.16±0.10(Predicted)
form	powder
color	white to off-white
Merck	14,5083
BCS Class	2
CAS DataBase Reference	138402-11-6(CAS DataBase Reference)
EPA Substance Registry System	1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (138402-11-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS09,GHS02

Signal word

Danger

Hazard statements

H413

Precautionary statements

P501-P273

Hazard Codes

Risk Statements

Safety Statements

26-24/25

WGK Germany

RTECS

HM2950270

HS Code

29332900

NFPA 704

	0
2		0

Irbesartan price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR1443	Irbesartan Pharmaceutical Secondary Standard; Certified Reference Material	138402-11-6	1G	₹9103.83	2022-06-14	Buy
Sigma-Aldrich(India)	I2286	Irbesartan ≥98% (HPLC), powder	138402-11-6	10MG	₹9428.58	2022-06-14	Buy
Sigma-Aldrich(India)	I2286	Irbesartan ≥98% (HPLC), powder	138402-11-6	50MG	₹38017.4	2022-06-14	Buy
TCI Chemicals (India)	I0859	Irbesartan	138402-11-6	1G	₹5500	2022-05-26	Buy
TCI Chemicals (India)	I0859	Irbesartan	138402-11-6	5G	₹6900	2022-05-26	Buy

Product number	Packaging	Price	Buy
PHR1443	1G	₹9103.83	Buy
I2286	10MG	₹9428.58	Buy
I2286	50MG	₹38017.4	Buy
I0859	1G	₹5500	Buy
I0859	5G	₹6900	Buy

Irbesartan Chemical Properties,Uses,Production

Description

Avapro was launched in Germany, the UK and the US for hypertension. It can be prepared in six steps starting with cyclopentanone or in three steps from 1- aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro is an angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT, subtypes and has no AT₂ activity at postsynaptic receptors compared to presynatpic. It has no affinity for various non angiotensin Ⅱ receptor types in binding, no interaction with calcium channels or antiports, and no affinity for α₁- and α₂--adrenoreceptors, serotonergic receptors, muscarinic m₁ and m₂ or other receptors. It is as potent as saralasin but with no agonist activity and is 10 times more potent than DuP753 in rats. It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol, while more effective than losartan for mild to moderate hypertension.

Chemical Properties

Crystalline Solid

Uses

For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges

Definition

ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

General Description

Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.

Irbesartan Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID Triethyl orthobutyrate Sodium azide ORTHO-N-VALERIC ACID TRIETHYL ESTER Fluorene

Tetrazole Benzylamine Valeryl chloride Cyclopentanone Triphenylmethyl Chloride

Cycloleucine Sodium cyanide ETHYL PENTANIMIDATE Tributyltin azide Triethylamine

4-Bromomethyl-2-cyanobiphenyl Oxalic acid dihydrate

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Preparation Products

METHYL TRIPHENYLMETHYL ETHER

Irbesartan Suppliers

Global( 792)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4542	58	Inquiry
Cadila Pharmaceuticals Ltd	+91-7069076657 +91-7069076657	Ahmedabad, India	54	58	Inquiry
ANWITA APIS	+919000311012	Hyderabad, India	198	58	Inquiry
Dr. Reddy's Laboratories Ltd	+91-4049002900 +91-4049002900	Hyderabad, India	165	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Macleods Pharmaceuticals Limited	+91-2266762800 +91-2266762800	Maharashtra, India	116	58	Inquiry
Divis Laboratories Ltd	+91-4066966413 +91-4066966413	Hyderabad, India	34	58	Inquiry
CTX Lifesciences Pvt Ltd	+91-2612399669 +91-7434851395	Gujarat, India	28	58	Inquiry
Sun Pharmaceutical Industries Ltd	+91-2242244224 +91-2243244324	Maharashtra, India	108	58	Inquiry
Unichem Laboratories Ltd	+91-2266888333 +91-2266888333	Maharashtra, India	62	58	Inquiry

Supplier	Advantage
GLR Innovations	58
Cadila Pharmaceuticals Ltd	58
ANWITA APIS	58
Dr. Reddy's Laboratories Ltd	58
Hetero Drugs Limited	58
Macleods Pharmaceuticals Limited	58
Divis Laboratories Ltd	58
CTX Lifesciences Pvt Ltd	58
Sun Pharmaceutical Industries Ltd	58
Unichem Laboratories Ltd	58

Irbesartan Spectrum

Irbesartan(138402-11-6)¹HNMR

138402-11-6(Irbesartan)Related Search:

4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-(1,1'-biphenyl)-2-carbonitrile 2-Butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride Irbesartan Related Compound A Trityl Irbesartan Irbesartan

2-n-butyl-l,3-diazaspiro[4,4]non-l-ene-4-one(for Irbesartan) Irbesartan N--D-Glucuronide IRBESARTAN-D4 IRBESARTAN-D3 2-butyl-1,3-biazaspiro[4,4]-non-1-ene-4-one hydrochloride (intermediate of Irbesartan)

Irbesartan Tablets Irbesartan13 IRBESARTAN (GMP) intermediate of irbesartan 4-bromomethyl-2-(1-triphenylmethyltetrazole-5-yl)biphenyl (intermediate of Irbesartan)

Irbesartan2-(4-AminomethylPhenyl)Benzonitrile IRBESARTAN Irbesartan, Crude

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2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE IRBESARTAN BMS-186295 APROVEL 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 2-Isopropryl-4-methylthiazole 2-butyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one 2-butyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one 2-Isopropryl-4-methylthiazole (Irbesartan) Irbesartan (200 mg) Irbesartan(Avapro) 2-butyl-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one Irbesartan Synonyms 3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one 2N-Butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride IrbesartanC25H28N6O 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, BMS-186295, SR-47436, Aprovel, Avapro IRBESARTAN/3-BYTY1-3-[P-(0-1H-TETRAZOL-5-Y1-PHENY1)BENZY1],3-DIAZOSPIRO[4,4]NON-1-EN-4-KETONE 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE(IRBESARTAN) 2-buty1-3-[p-(0-1H-tetrazol-5-y1-pheny1)benzy1]1,3-diazospiro[4,4]non-1-en-4-ketone 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4- Irbersartan 2-BUTYL-3-[2''-(1H-TETRAZOL-5-YL)BIPHENYL-4-YLMETHYL]1,3-DIAZA-SPIRO[4.4]NON-1-EN-4-ONE 2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4- Irbesarta 2-Butyl-3-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1，3-diazaspiro[4.4]non-1-en-4-one SR-47436 CS-1097 AVAPRO; SR-47436; BMS-186295 ebeisaotan 2-butyl-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one Irbesartan (SR-47436 Irbesartan, 99%, a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist Irbesartan Control Irbesartan> Irbesartan CRS Irbesartan USP/EP/BP Irbesartan (1347700) 3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one AVAPRO Irbesatan Lrbesartan Irbesartan Impurity 1 tert-Butyl peroxybenzoate 614-45-9 IRBESARTAN 50% GRANULES Irbesartan 2-Butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3- diazaspiro[4.4]non-1-en-4-one Irbesartan Reference Standard 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one 138402-11-6 C25H28N6O 42854 C25H28ON6