Triphenylmethyl Chloride
- CAS No.
- 76-83-5
- Chemical Name:
- Triphenylmethyl Chloride
- Synonyms
- TRT-CL;TRITYL CHLORIDE;(ChloroMethanetriyl)tribenzene;CHLOROTRIPHENYLMETHANE;TRIPHENYLCHLOROMETHANE;[Chloro(diphenyl)methyl]benzene;TRITY CHLORIDE;TRIPHENYLCHLORMETHANE;chlorotriphenyl-methan;NSC 435
- CBNumber:
- CB8669405
- Molecular Formula:
- C19H15Cl
- Molecular Weight:
- 278.78
- MOL File:
- 76-83-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/9 17:53:44
| Melting point | 109-112 °C(lit.) |
|---|---|
| Boiling point | 230-235 °C20 mm Hg(lit.) |
| Density | 1.1088 (rough estimate) |
| refractive index | 1.6281 (estimate) |
| Flash point | 230-235°C/20mm |
| storage temp. | Store below +30°C. |
| solubility | chloroform: 0.1 g/mL, clear |
| form | Powder or Crystals |
| color | White to off-white or light yellow-beige |
| Water Solubility | Insoluble in water. Soluble in chloroform, hexane, benzene, ether, acetone and tetrahydrofuran. |
| Sensitive | Lachrymatory |
| BRN | 397363 |
| CAS DataBase Reference | 76-83-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Triphenylmethyl chloride(76-83-5) |
| EPA Substance Registry System | Chlorotriphenylmethane (76-83-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C,N | |||||||||
| Risk Statements | 34-50/53-14-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45-61-27 | |||||||||
| RIDADR | UN 3261 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PA6450000 | |||||||||
| F | 10-19-21 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29036990 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Triphenylmethyl Chloride price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T83801 | Trityl chloride 97% | 76-83-5 | 25G | ₹1959.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T83801 | Trityl chloride 97% | 76-83-5 | 100G | ₹2803.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T83801 | Trityl chloride 97% | 76-83-5 | 500G | ₹7036.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93000 | Trityl chloride purum, ≥97.0% (HPLC), ≥97.0% (AT) | 76-83-5 | 100G | ₹4262.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93000 | Trityl chloride purum, ≥97.0% (HPLC), ≥97.0% (AT) | 76-83-5 | 500G | ₹9136.3 | 2022-06-14 | Buy |
Triphenylmethyl Chloride Chemical Properties,Uses,Production
Chemical Properties
Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.
Uses
Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.
Application
Triphenylmethyl Chloride acts as a protecting reagent for amines, alcohols, and thiols. It can be used as a catalyst:
Efficient method of tritylation of sensitive compounds and their subsequent detritylation.
In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile.
In the synthesis of 1,2,4,5-tetrasubstituted imidazoles via a one-pot multi-component reaction of benzil with aldehydes, primary amines, and ammonium acetate.
In the preparation of amido alkyl phenols via one-pot, multi-component reaction of phenols, aromatic aldehydes, and amides under solvent-free conditions.
In one-pot, multi-component synthesis of substituted piperidines using aromatic aldehydes, amines, and β-ketoesters.
Preparation
Triphenylmethyl Chloride may be prepared by the reaction of triphenylmethanol with acetyl chloride, or by the Friedel–Crafts alkylation of benzene with carbon tetrachloride to give the trityl chloride-aluminium chloride adduct, which is then hydrolyzed.
Purification Methods
Crystallise trityl chloride from iso-octane. Also crystallise it from 5 parts of pet ether (b 90-100o) and 1 part of acetyl chloride using 1.8g of solvent per g of chloride. Dry it in a desiccator over soda lime and paraffin wax. [Bachman Org Synth Coll Vol III 841 1955, Thomas & Rochow J Am Chem Soc 79 1843 1957, Moisel et al. J Am Chem Soc 108 4706 1986, Beilstein 5 H 750, 5 I 346, 5 II 615, 5 III 2315, 5 IV 2497.] It is moisture sensitive and LACHRYMATORY,
Triphenylmethyl Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| RIDDHI PHARMA | 58 |
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| GSV speciality chemicals | 58 |
| Vardhaman P Golechha | 58 |
| Credas Labs Pvt Ltd | 58 |
| ANJI BIOSCIENCES | 58 |
| AMINO ORGANICS | 58 |
| SYNGENESIS CHEMSCIENCE PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| SHIVAM PETROCHEM INDUSTRIES | 58 |
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