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Cefoperazone

Cefoperazone Structure
CAS No.
62893-19-0
Chemical Name:
Cefoperazone
Synonyms
CEFOPERAZONE ACID;Cefoperazone (Cefobid);(6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cefob;l~rdum;Medocef;CEFOPERAZONE;cefoperazine;Cephaperazon;Cefoperazoner
CBNumber:
CB4752040
Molecular Formula:
C25H27N9O8S2
Molecular Weight:
645.67
MOL File:
62893-19-0.mol
MSDS File:
SDS
Modify Date:
2024/4/25 13:42:50
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Cefoperazone Properties

Melting point 169-171 C
Density 1.77±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form Solid
pka pKa 2.6 (Uncertain)
color White to Off-White
Merck 14,1930
InChIKey GCFBRXLSHGKWDP-XCGNWRKASA-N
SMILES N12[C@@]([H])([C@H](NC([C@H](NC(N3CCN(CC)C(=O)C3=O)=O)C3=CC=C(O)C=C3)=O)C1=O)SCC(CSC1N(C)N=NN=1)=C2C(O)=O
CAS DataBase Reference 62893-19-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
RTECS  XI0373900
HS Code  29419000

Cefoperazone Chemical Properties,Uses,Production

Description

Cefoperazone has a C-7 side chain reminiscent of piperacillin's and also possesses the C-3 side chain (MTT ) that often is associated with the bleeding and alcohol intolerance problems among patients taking cephalosporins. Its useful activity against pseudomonads partly compensates for this, although it is not potent enough to be used as a single agent against this difficult pathogen. The C-7 side chain does not convey sufficient resistance to many β-lactamases, although the addition of clavulanic acid or sulbactam would presumably help.

Chemical Properties

white crystals

Uses

Cefoperazone also has a broad spectrum of antimicrobial action, including most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is stable with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria.
Cefoperazone is used for bacterial infections of the lower respiratory tract, urinary and sexual tracts, bones, joints, skin, soft tissues, abdominal, and gynecological infections. Synonyms of this drug are cefazon, cefobid, cefobis, and many others.

Definition

ChEBI: A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.

Cefoperazone Preparation Products And Raw materials

Raw materials

1-Phenyltetrazole-5-thiol Acetaminophen Pyrazine Nitrogen Acetone
p-Toluenesulfonic acid monohydrate Tetrazole Chlorotrimethylsilane Acid chloride 5-Mercapto-1-methyltetrazole
N,N-Dimethylacetamide (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline {[(4-Ethyl-2,3-Dioxo-1-Piperazinyl) Carbonyl]Amino}-4-Hydroxy-Benzene Acetic Acid
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Preparation Products

Cefoperazone Suppliers

Global( 327)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
PROTECH TELELINKS +91-8571891912 +91-9855060837 Himachal Pradesh, India 62 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
G.C Chemie Pharmie Ltd. 91-22-26332365 Maharashtra, India 42 58 Inquiry
Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Uniword Pharma (A Subsidiary Of Uniword Marketing Pvt... 08048371522Ext 184 Punjab, India 4 58 Inquiry
Insta Chemi Private Limited 08048958481 Uttar Pradesh, India 122 58 Inquiry
Chephis Corporation 09867726678 Mumbai, India 115 58 Inquiry
Supplier Advantage
PROTECH TELELINKS 58
GLP Pharma Standards 58
G.C Chemie Pharmie Ltd. 58
Medilink Pharmachem 50
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Uniword Pharma (A Subsidiary Of Uniword Marketing Pvt... 58
Insta Chemi Private Limited 58
Chephis Corporation 58

Related articles

Cefoperazone Spectrum

Cefoperazone(62893-19-0)1HNMR

62893-19-0(Cefoperazone)Related Search:

7-TMCA (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid 4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride Cefoperazone sodium +sulbactam sodium(1:1/2:1),Cefoperazone sodium/sullbactam sodium CEFADROXIL
Cefoperazone SALOR-INT L169811-1EA 1-Ethyl-2,3-dioxopiperazine Cephalexin 7-Phenyl-acetamido-deacetoxy-cephalosporanic-acid
Cefadroxil Cefoperazone acid(sodium) CP2000,USP24,EP2001,CEFOPERAZONE SODIUM,CEFOPERAZONE SODIUM SALT sodium [6R-[6alpha,7beta(R*)]]-7-(aminophenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate BENZENEACETAMIDE, N-(2-AMINOETHYL)-4-HYDROXY- Sulbactam sodium·cefoperazone sodium,Cefoperazone sodium·sulbactam sodium
PIPERAZINE-2,3-DIONE CEFOPERAZONE SODIUM FOR INJECTION Cefoperazone dihydrate
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(6R,7R)-7-{[(2S)-2-{[(4-ETHYL-2,3-DIOXO-1-PIPERAZINYL)CARBONYL]AMINO}-2-(4-HYDROXYPHENYL)ACETYL]AMINO}-3-{[(1-METHYL-1H-TETRAZOL-5-YL)SULFANYL]METHYL}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBO XYLIC ACID CEFOPERAZONE 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]aMino]-2-(4-hydroxyphenyl)acetyl]aMino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,(6R,7R)- (6R,7R)-7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6r-(6-alpha,7-beta(r*)))--tetrazol-5-yl)thio)methyl)-8-oxo -1-piperazinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3-(((1-methyl-1h cefoperazine Cefobis：Cefogram l~rdum Perocef：Tomabef Cefoperazone Dihydrate (200 mg) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(R*)]]- Cefob Cephaperazon Medocef Cefoperazone (base and/or unspecified salts) Cefoperazone SodiuM IMp. B Cefoperazone free acid [6R-[6alpha,7beta(R*)]]-7-[[[[(4-Ethyl-2,3-dioxo-1- piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6S,7S)-7-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)-oxomethyl]amino]-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Cefoperazone dihydrate CRS Cefoperazone USP/EP/BP Cefoperazoner Cefoperazone acid, Pharma CEFOPERAZONE ACID Cefoperazone (Cefobid) (6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Trolamine Impurity 5 62893-19-0 C25H27N9O8S2 Inhibitors Pharmaceutical