Cefoperazone sodium
- CAS No.
- 62893-20-3
- Chemical Name:
- Cefoperazone sodium
- Synonyms
- CEFOBID;T-1551;Dardum;Cefobis;Cefoneg;Farecef;Kefazon;Peracef;Perocef;Tomabef
- CBNumber:
- CB5448988
- Molecular Formula:
- C25H28N9NaO8S2
- Molecular Weight:
- 669.66
- MOL File:
- 62893-20-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/6 18:26:58
| Melting point | 200-202°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, faintly yellow |
| form | powder |
| color | White to Off-White |
| Water Solubility | Soluble in water. Slightly soluble in alcohol. |
| Merck | 13,1943 |
| BRN | 4902135 |
| Stability | Hygroscopic |
| InChIKey | NCFTXMQPRQZFMZ-WERGMSTESA-M |
| SMILES | C(C1=C(CS[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)NC(N3CCN(CC)C(=O)C3=O)=O)C(=O)N12)CSC1=NN=NN1C)(=O)O.[NaH] |&1:5,7,11,r| |
| CAS DataBase Reference | 62893-20-3(CAS DataBase Reference) |
Cefoperazone sodium price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C4292 | Cefoperazone sodium salt 870-1015 μg/mg (anhydrous basis) | 62893-20-3 | 1G | ₹7187.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4292 | Cefoperazone sodium salt 870-1015 μg/mg (anhydrous basis) | 62893-20-3 | 5G | ₹18554.05 | 2022-06-14 | Buy |
| SRL | 85254 | Cefaperazone Sodium (CFZ, Cefoperazone Sodium) | 62893-20-3 | 1Gms | ₹1210 | 2022-05-26 | Buy |
| SRL | 85254 | Cefaperazone Sodium (CFZ, Cefoperazone Sodium) | 62893-20-3 | 5Gms | ₹4950 | 2022-05-26 | Buy |
Cefoperazone sodium Chemical Properties,Uses,Production
Description
Cefoperazone was synthesized by Toyama Chemicals Co. in 1978. Except for the hydroxyl group, the side chain attached to the cephem nucleus is the same as that of piperacillin. Cefoperazone shows excellent activity against gram-positive (except Staphylococcus) and gram- negative bacteria, including Pseudomonas aeruginosa. Its pharmacological characteristics are unique. Cefoperazone is excreted mainly in bile, and a concentration five to tenfold higher in bile than in serum is obtained. The transfer into cerebrospinal fluid is 10 – 30 % of the serum concentration; the half-life in serum is 2.0 – 2.6h, and the degree of binding with serum protein is as high as 86.6 %.
Chemical Properties
Faint beige powder
Uses
For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.
Clinical Use
Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.
Cefoperazone sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Vaishali Pharma Pvt., Ltd. | 91-22-42171819 | Maharashtra, India | 49 | 58 | Inquiry |
| Pluto International | 09820708841 | Mumbai, India | 57 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |