Cefadroxil
- CAS No.
- 66592-87-8
- Chemical Name:
- Cefadroxil
- Synonyms
- AMOXYCILLIN;CEFADROXIL MONOHYDRATE;Cefadroxil hydrate;CEFADROXILE;Baxan;CEFAMOX;Duracef;Cefa-Drops;CEFADROXIL;Cefradroxil
- CBNumber:
- CB4203658
- Molecular Formula:
- C16H17N3O5S.H2O
- Molecular Weight:
- 381.41
- MOL File:
- 66592-87-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
| Melting point | 197 °C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cen |
| pka | pKa 1.38(H2O t=20±2 N2atmosphere) (Uncertain); 7.35(H2O t=20±2 N2atmosphere) (Uncertain);10.10(H2O t=20±2 N2atmosphere) (Uncertain) |
| form | Solid |
| color | White to Off-White |
| BCS Class | 3 |
| InChIKey | NBFNMSULHIODTC-CYJZLJNKSA-N |
| CAS DataBase Reference | 66592-87-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 26-36-36/37 |
| WGK Germany | 2 |
| RTECS | XI0337000 |
| HS Code | 2941906000 |
Cefadroxil price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3579 | Cefadroxil certified reference material, pharmaceutical secondary standard | 66592-87-8 | 400MG | ₹18767.95 | 2022-06-14 | Buy |
| SRL | 15689 | Cefadroxil Monohydrate (CFD), 95% | 66592-87-8 | 1Gms | ₹1740 | 2022-05-26 | Buy |
| SRL | 15689 | Cefadroxil Monohydrate (CFD), 95% | 66592-87-8 | 5Gms | ₹5780 | 2022-05-26 | Buy |
Cefadroxil Chemical Properties,Uses,Production
Description
Cefadroxil has an amoxicillin-like side chain at C-7 and is orally active. There are some indications that cefadroxil has some immunostimulant properties mediated through T-cell activation and that this is of material assistance to patients in fighting infections. The prolonged biological half-life of cefadroxil allows once-a-day dosage.
Chemical Properties
White Crystalline Solid. Soluble in chloroform, miscible with ethanol and ether, insoluble in water, and will change color when exposed to light or for a long time.
Uses
Cefadroxil Monohydrate is a semi-synthetic cephalosporin antibacterial. It has been used for various community-acquired infections for which oral cephalosporins are appropriate.
Definition
ChEBI: The hydrate that is the monohydrate of the cephalosporin cefadroxil.
Antimicrobial activity
Resembles closely that of cefalexin
General Description
Cefadroxil is a semisynthetic first-generation β-lactam cephalosporin antibiotic derived from cefalexin with antibacterial activity. It is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis caused by susceptible bacteria.
Application
Cefadroxil was found by Bristol-Myers Co. in 1976. A hydroxyl group was attached to the benzene ring of cephalexin. Like amoxicillin and ampicillin, cefadroxil shows almost the same antibacterial activity spectrum as cephalexin and superior oral absorption. Its in vivo activity is four to six times greater than that of cephalexin, and its half-life in serum is twice as long.
Pharmacology
Cefadroxil has a broad spectrum of antimicrobial action; it is active with respect to Grampositive and Gram-negative microorganisms. Like all of the other drugs described above, it acts as a bactericide by disrupting the process of restoring the membranes of bacteria. Synonyms of this drug are bidocef, cefadril, duracef, ultracef, and others.
Pharmacokinetics
Oral absorption: >90%
Cmax 250 mg oral: c. 9 mg/L after 1.2 h
500 mg oral: c. 18 mg/L after 1.2 h
Plasma half-life: 1–1.5 h
Plasma protein binding : 20%
Absorption is little affected by administration with food.
Distribution is similar to that of cefalexin. It is eliminated
unchanged by glomerular filtration and tubular secretion;
90% of the dose appears in the urine over 24 h, most in the
first 6 h, producing concentrations exceeding 500 mg/L.
Clinical Use
Cefadroxil (Duricef) is an orally active semisyntheticderivative of 7-ADCA, in which the 7-acyl group is the Dhydroxylphenylglycylmoiety. This compound is absorbedwell after oral administration to give plasma levels that reach75% to 80% of those of an equal dose of its close structuralanalog cephalexin. The main advantage claimed for cefadroxilis its somewhat prolonged duration of action, whichpermits once-a-day dosing. The prolonged duration of actionof this compound is related to relatively slow urinary excretionof the drug compared with other cephalosporins, butthe basis for this remains to be explained completely. Theantibacterial spectrum of action and therapeutic indications ofcefadroxil are very similar to those of cephalexin and cephradine.The D-p-hydroxyphenylglycyl isomer is much moreactive than the L-isomer.
Side effects
Side effects described are those common to oral cephalosporins.
Cefadroxil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Chemicea Pharmaceuticals Pvt Ltd | +91-918482849343 +91-8482849343 | Mumbai, India | 461 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| ORCHID PHARMA LTD | +91 - 44 - 2821 1000 | New Delhi, India | 69 | 58 | Inquiry |
| LUPIN LTD | +91 124 4885000 / +91 124 3325000 | New Delhi, India | 191 | 58 | Inquiry |
| ORCHID PHARMA LIMITED | +91–44–2744 4471/72/73/74/75/76/77/78 | New Delhi, India | 32 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Chemicea Pharmaceuticals Pvt Ltd | 58 |
| Aurobindo Pharma Limited | 58 |
| OCEAN TRADING CORPORATION | 58 |
| Medilink Pharmachem | 50 |
| AUROBINDO PHARMA LTD | 58 |
| ORCHID PHARMA LTD | 58 |
| LUPIN LTD | 58 |
| ORCHID PHARMA LIMITED | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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