Cefadroxil manufacturers and suppliers in india

Cefadroxil

Properties

Melting point:: 197 °C

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cen

pka: pKa 1.38(H2O t=20±2 N2atmosphere) (Uncertain); 7.35(H2O t=20±2 N2atmosphere) (Uncertain);10.10(H2O t=20±2 N2atmosphere) (Uncertain)

form: Solid

color: White to Off-White

BCS Class: 3

InChIKey: NBFNMSULHIODTC-CYJZLJNKSA-N

Safety Information

Symbol(GHS): GHS05

Signal word: Danger

Hazard statements: H314

Precautionary statements: P280-P305+P351+P338-P310

Hazard Codes: Xn,Xi

Risk Statements: 36/37/38-42/43

Safety Statements: 26-36-36/37

WGK Germany: 2

RTECS: XI0337000

HS Code: 2941906000

Use

Cefadroxil (Duricef) is an orally active semisyntheticderivative of 7-ADCA, in which the 7-acyl group is the Dhydroxylphenylglycylmoiety. This compound is absorbedwell after oral administration to give plasma levels that reach75% to 80% of those of an equal dose of its close structuralanalog cephalexin. The main advantage claimed for cefadroxilis its somewhat prolonged duration of action, whichpermits once-a-day dosing. The prolonged duration of actionof this compound is related to relatively slow urinary excretionof the drug compared with other cephalosporins, butthe basis for this remains to be explained completely. Theantibacterial spectrum of action and therapeutic indications ofcefadroxil are very similar to those of cephalexin and cephradine.The D-p-hydroxyphenylglycyl isomer is much moreactive than the L-isomer.