Cephalothin sodium

Cephalothin sodium Properties

Melting point	240°C
alpha	D +135° (c = 1.0 in water)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, faintly yellow
form	Solid
color	White to Off-White
Water Solubility	158 mg/L
Merck	13,1994
BRN	4120706
Stability	Hygroscopic
CAS DataBase Reference	58-71-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P280-P284-P304+P340-P342+P311
Hazard Codes	Xn,Xi
Risk Statements	42/43
Safety Statements	22-36/37
WGK Germany	2
RTECS	XI0388300
HS Code	29419000
Toxicity	LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)

Cephalothin sodium price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C4520	Cephalothin sodium salt	58-71-9	100MG	₹2890.28	2022-06-14	Buy
Sigma-Aldrich(India)	C4520	Cephalothin sodium salt	58-71-9	250MG	₹3377.4	2022-06-14	Buy
Sigma-Aldrich(India)	C4520	Cephalothin sodium salt	58-71-9	1G	₹7739.88	2022-06-14	Buy
Sigma-Aldrich(India)	C4520	Cephalothin sodium salt	58-71-9	5G	₹26348.05	2022-06-14	Buy
SRL	36413	Cephalothin Sodium Salt (CF), 97%	58-71-9	1Gms	₹3170	2022-05-26	Buy

Product number	Packaging	Price	Buy
C4520	100MG	₹2890.28	Buy
C4520	250MG	₹3377.4	Buy
C4520	1G	₹7739.88	Buy
C4520	5G	₹26348.05	Buy
36413	1Gms	₹3170	Buy

Cephalothin sodium Chemical Properties,Uses,Production

Description

Cefalothin is a β-lactam cephalosporin antibiotic. It inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively). Cefalothin binds to E. coli penicillin-binding proteins (PBPs; IC₅₀s = <0.25, 16, 37, and 1 μg/ml for PBP1a, 1bs, 2, and 3, respectively, in a radioligand binding assay), which interferes with bacterial morphogenesis. It exhibits antibacterial activity in mouse models of infection with S. pyogenes, D. pneumoniae, and S. aureus. Formulations containing cefalothin were previously used in the prophylaxis and treatment of bacterial infections.

Chemical Properties

Crystalline

Uses

Cephalothin sodium salt is used to study the mechanism of liposome encapsulated antibiotics1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics2, and for immunology studies in relation to antibiotics.3 It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

General Description

Cephalothin, along with cephaloridine, was the first of the synthetic cephalosporin C class antibiotics to be introduced clinically. It was synthesized from 7-amino-cephalosporanic acid by Lilly Research Laboratories in 1962. Cephalothin shows strong activity against gram-positive and gram-negative bacteria and Leptospira, including benzylpenicillin-resistant strains. It has been used intravenously and intramuscularly to treat a variety of infections caused by Staphylococcus, Streptococcus, Escherichia coli, and Neisseria. The drug is metabolized in vivo, and the metabolite, deacetylcephalothin, is almost inactive.

Clinical Use

Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. It is freelysoluble in water and insoluble in most organic solvents.Although it has been described as a broad-spectrum antibacterialcompound, it is not in the same class as the tetracyclines.Its spectrum of activity is broader than that ofpenicillin G and more similar to that of ampicillin. Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains.
Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. It is relatively nontoxic and acid stable. It is excreted rapidlythrough the kidneys; about 60% is lost within 6 hours of administration.Pain at the site of intramuscular injection andthrombophlebitis following intravenous injection have beenreported. Hypersensitivity reactions have been observed,and there is some evidence of cross-sensitivity in patientsnoted previously to be penicillin sensitive.

Cephalothin sodium Preparation Products And Raw materials

Raw materials

Thiophene acetyl chloride Sodium acetate trihydrate 7-(5-amino-5-carboxyvaleramido)cephalosporanic acid Butyl acetate 7-Aminocephalosporanic acid

Thionyl chloride Sodium hydroxide 2-Thiopheneacetic acid

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Preparation Products

Cefuroxime (6R-cis)-3-(acetoxymethyl)-7-methoxy-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cephalothin sodium Suppliers

Global( 306)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
Aavyan Labs	+91-9652399498 +91-9652399498	Telangana, India	60	58	Inquiry
Aruvi Labs	+91-8056181939 +91-8056181939	Tamil Nadu, India	149	58	Inquiry
Aavyan Labs	91-9652399498	Hyderabad, India	19	58	Inquiry
Anika International Pvt. Limited	91-11-47289900	Delhi, India	94	58	Inquiry
Aruvi Labs	91-0-8056181939	Tamil Nadu, India	68	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry
Medkem Laboratories	91-40-23700606	Andhra Pradesh, India	297	58	Inquiry
Metro Exporters Pvt. Ltd.	91-22-24916500	Maharashtra, India	204	58	Inquiry
Anand Agencies	91-20-24454597	Maharashtra, India	2337	58	Inquiry

Supplier	Advantage
GLP Pharma Standards	58
Aavyan Labs	58
Aruvi Labs	58
Aavyan Labs	58
Anika International Pvt. Limited	58
Aruvi Labs	58
Maas Pharma Chemicals	58
Medkem Laboratories	58
Metro Exporters Pvt. Ltd.	58
Anand Agencies	58

Cephalothin sodium Spectrum

Cephalothin sodium(58-71-9)¹HNMR

58-71-9(Cephalothin sodium)Related Search:

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Cefoxitin 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Ceftiofur

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SodiuM (6R,7R)-3-(acetoxyMethyl)-8-oxo-7-(2-(thiophen-2-yl)acetaMido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cephalotin sodium salt, Antibiotic for Culture Media Use Only monosodium (6r,7r)-3-acetoxymethyl-8-oxo-7-[2-(thiophen-2-yl)acetylamido]-5-thia-1-azabicyclo[4.2.0.]oct-2-ene-2-carboxylate synclotin Sodium cephalothin 7-(2-(2-thienyl)acetamido)-,acetate,monosodiumsalt cefalothinesodium cefalotinasodica Cefalotin Sodium(Sterile) Cefalotin Free acid CEPHALOTIN ACID 3-(Acetoxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-, acetate (ester) (8CI) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R-trans)- 7-(Thiophene-2-acetamido)cephalosporin 7-[2-(2-Thienyl)acetylamido]cephalosporanic acid Cephalotin 38253 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-, acetate (ester), monosodium salt (8CI) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, monosodium salt, (6R-trans)- Averon 1 Cemastin Cephation Ceporacin Cepovenin Coaxin Keflin Lospoven Seffin Sodium (thienylacetamido)cephalosporanate Sodium 3-acetoxymethyl-7b-(2-thienylacetamido)ceph-3-em-4-carboxylate Sodium 7-(2-thienylacetamido)-3-acetoxymethyl-3-cephem-4-carboxylate Sodium 7-[2-(2-thienyl)acetamido]cephalosporanate Sodium cefalotin CEFALOTHIN NA CEFALOTHIN SODIUM CEFALOTIN SODIUM CEPHALOTHIN SODIUM SALT CEPHALOTIN SODIUM SALT 7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt (6r,7r)-3-(acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7-(2-THIENYLACETAMIDO)CEPHALOSPORANIC ACID 7-(2-THIENYLACETAMIDO)CEPHALOSPORANIC ACID SODIUM SALT Cefalotin acid Cefalothin Sodium cephalotin (6r-trans)-oxo-7-((2-thienylacetyl)amino) 3-((acetyloxy)methyl)-8-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic aci 3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic aci 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-th ia-1-azabicyclo[4.2.0]o 6r-trans-3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacety l)amino]-5-thia-1-azabi ct-2-ene-2-carboxylic acid acetate cyclo[4.2.0]-oct-2-ene-2-carboxylic acid cephalothin sodium cell culture tested cephalothin sodium crystalline Cephalothin (base and/or unspecified salts)