Tetrahydrothiophene
- CAS No.
- 110-01-0
- Chemical Name:
- Tetrahydrothiophene
- Synonyms
- THT;Tetrahydrothiophen;Thiophene, tetrahydro-;THIOLANE;THIOPHANE;TETRAMETHYLENE SULFIDE;TETRAHYDROTHIOPHEN 99%(GC);Thilane;Thiofan;THIOLAN
- CBNumber:
- CB9402977
- Molecular Formula:
- C4H8S
- Molecular Weight:
- 88.17
- MOL File:
- 110-01-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | -96 °C (lit.) |
|---|---|
| Boiling point | 119 °C (lit.) |
| Density | 1 g/mL at 25 °C (lit.) |
| vapor pressure | 18 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 55 °F |
| storage temp. | Store below +30°C. |
| solubility | immiscible |
| form | liquid |
| Specific Gravity | 1.002 (20/4℃) |
| color | Colorless to Almost colorless |
| Odor | Smells of rotting eggs |
| PH | 7 (H2O, 20℃) |
| explosive limit | 1.1-12.1%(V) |
| Odor Threshold | 0.00062ppm |
| Odor Type | sulfurous |
| Water Solubility | immiscible |
| Merck | 14,9218 |
| BRN | 102392 |
| Dielectric constant | 8.6099999999999994 |
| Stability | Highly flammable. Vapour-air mixtures explosive in some proportions; note low flash point and fairly wide explosion limit range. Heavier than air, so potentially explosive mixtures may travel considerable distances to source of ignition. |
| LogP | 1.8 at 20℃ |
| CAS DataBase Reference | 110-01-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiophene, tetrahydro-(110-01-0) |
| EPA Substance Registry System | Tetrahydrothiophene (110-01-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H312+H332-H315-H319-H412 | |||||||||
| Precautionary statements | P210-P273-P280-P301+P312-P303+P361+P353-P304+P340+P312 | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 11-20/21/22-36/38-52/53 | |||||||||
| Safety Statements | 16-23-36/37-61 | |||||||||
| RIDADR | UN 2412 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XN0370000 | |||||||||
| Autoignition Temperature | 202 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 by inhalation in mice: 26.7 mg/l (Carlucci) | |||||||||
| NFPA 704 |
|
Tetrahydrothiophene price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T15601 | Tetrahydrothiophene 99% | 110-01-0 | 5G | ₹2684.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T15601 | Tetrahydrothiophene 99% | 110-01-0 | 100G | ₹4795.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T15601 | Tetrahydrothiophene 99% | 110-01-0 | 500G | ₹7512.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21095 | Tetrahydrothiophene for synthesis | 110-01-0 | 5ML | ₹1610.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21095 | Tetrahydrothiophene for synthesis | 110-01-0 | 250ML | ₹5350 | 2022-06-14 | Buy |
Tetrahydrothiophene Chemical Properties,Uses,Production
Chemical Properties
Tetrahydrothiophene is cyclic thioalkane, namely, saturated analog of thiophene. It is a colorless transparent volatile liquid, insoluble in water, miscible in ethanol, ether, benzene, acetone. It has a strong unpleasant odor, is stable and not easily emitted, and can be smelled in the air at 0.01PPm. It is not corrosive to gas equipment, transportation pipeline gaskets and other materials, and does not produce habitual blunting of the human sense of smell, so it is used as an odorant in LPG and natural gas, outlawing the original use of ethyl mercaptan and other odor-assigning agents.
Uses
Tetrahydrothiophene is used as pharmaceutical and agrochemical intermediates.
Preparation
Tetrahydrothiophene is prepared by the reaction of hydrogen sulfide and furan in the vapor phase at 400°C. This vapor-phase reaction is catalyzed by alumina(Al2O3) and other heterogenous acid catalysts.
General Description
A water-white liquid. About the same density as water and insoluble in water. Flash point near 20°F. Vapors heavier than air. Used as a solvent and to make other chemicals.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Organosulfides, such as Tetrahydrothiophene, are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Slow addition of hydrogen peroxide to the thiophene resulted in explosions on three occasions, Chem. Eng. News, 1974, 52(39), 3.
Health Hazard
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Mildly toxic by inhalation. Flammable liquid. Potentially explosive reaction with hydrogen peroxide. When heated to decomposition it emits toxic fumes of SOx.
Purification Methods
The crude material is purified by crystallisation of the mercuric chloride complex to a constant melting point. It is then regenerated, washed, dried, and fractionally distilled. [Whitehead et al. J Am Chem Soc 73 3632 1951.] It has been dried over Na2SO4 and distilled in a vacuum [Roberts & Friend J Am Chem Soc 108 7204 1986]. [Beilstein 17 I 5, 17 II 15, 17 III/IV 34, 17/1 V 36.]
Tetrahydrothiophene Preparation Products And Raw materials
Raw materials
Preparation Products
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