Thiophene
- CAS No.
- 110-02-1
- Chemical Name:
- Thiophene
- Synonyms
- Thiophen;CYP3A;THIOFURAN;HLP;cp34;thiophenone;Thiacyclopentadiene;THIOPHENE FOR SYNTHESIS 5 ML;Thiophene, benzene free, extra pure, 99.5%;CP33
- CBNumber:
- CB5852798
- Molecular Formula:
- C4H4S
- Molecular Weight:
- 84.14
- MOL File:
- 110-02-1.mol
- Modify Date:
- 2023/12/22 17:53:22
| Melting point | -38 °C (lit.) |
|---|---|
| Boiling point | 84 °C (lit.) |
| Density | 1.051 g/mL at 25 °C (lit.) |
| vapor density | 2.9 (vs air) |
| vapor pressure | 40 mm Hg ( 12.5 °C) |
| refractive index |
n |
| Flash point | -9 °C |
| storage temp. | Store below +30°C. |
| solubility | Miscible with carbon tetrachloride, heptane, pyrimidine, dioxane, toluene, and many organic solvents (quoted, Keith and Walters, 1992) |
| form | powder |
| color | Clear |
| Specific Gravity | 1.06 |
| Odor | at 0.10 % in propylene glycol. alliaceous garlic |
| Odor Type | sulfurous |
| Odor Threshold | 0.00056ppm |
| explosive limit | 1.5-12.5%(V) |
| Water Solubility | INSOLUBLE |
| Merck | 14,9353 |
| BRN | 103222 |
| Henry's Law Constant | 2.33 and 2.70 in distilled water and seawater, respectively (Przyjazny et al., 1983) |
| Dielectric constant | 9.3（20℃） |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents, nitrates. |
| LogP | 1.81-1.86 at pH10 |
| CAS DataBase Reference | 110-02-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiophene(110-02-1) |
| EPA Substance Registry System | Thiophene (110-02-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302-H319-H340-H350-H412 | |||||||||
| Precautionary statements | P202-P210-P273-P301+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | F,Xn,Xi,T | |||||||||
| Risk Statements | 45-46-11-20/21/22-41-52/53-36-20/22-37/38-22-48/20/21/22 | |||||||||
| Safety Statements | 53-26-39-45-61-36/37/39-16-36 | |||||||||
| RIDADR | UN 2414 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XM7350000 | |||||||||
| Autoignition Temperature | 743 °F | |||||||||
| Hazard Note | Irritant/Highly Flammable | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1400 mg/kg | |||||||||
| NFPA 704 |
|
Thiophene price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T31801 | Thiophene ≥99% | 110-02-1 | 5G | ₹1580.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T31801 | Thiophene ≥99% | 110-02-1 | 100G | ₹1980.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T31801 | Thiophene ≥99% | 110-02-1 | 500G | ₹5932.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.08157 | Thiophene for synthesis | 110-02-1 | 5ML | ₹1980 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.08157 | Thiophene for synthesis | 110-02-1 | 250ML | ₹6750.01 | 2022-06-14 | Buy |
Thiophene Chemical Properties,Uses,Production
Chemical Properties
Thiophene is a colourless to pale yellow liquid that has an odor similar to benzene. It is a heterocyclic compound with a five-membered ring containing four carbon atoms and one sulfur atom. The ring system is also known as a thienyl ring. It occurs as an impurity in commercial benzene and is used as a solvent and in organic syntheses.
Physical properties
Clear, colorless liquid with an aromatic odor resembling benzene. An odor threshold concentration of 0.056 ppbv was reported by Nagata and Takeuchi (1990).
Uses
Thiophene is used as a building block of various organic molecules and pharmaceuticals providing functional properties.
Production Methods
Thiophene is present in coal tar and is recovered in the benzene distillation fraction (up to about 0.5% of the benzene present). Its removal from benzene is accomplished by mixing with concentrated sulfuric acid, soluble thiophene sulfonic acid being formed. Thiophene gives a characteristic blue coloration with isatin in concentrated sulfuric acid. The basic nomenclature of the thiophene ring system and its derivatives is indicated by the following: the sulfur atom is number 1, positions 2 and 5 are equivalent in the parent ring, as are the 3 and 4 positions.
Definition
ChEBI: Thiophene is a monocyclic heteroarene that is furan in which the oxygen atom is replaced by a sulfur. It has a role as a non-polar solvent. It is a mancude organic heteromonocyclic parent, a member of thiophenes, a monocyclic heteroarene and a volatile organic compound.
General Description
Thiophene appears as a colorless liquid with an unpleasant odor. Insoluble in water and slightly denser than water. Flash point 30 °F. Vapors heavier than air. Irritates the skin, eyes, and mucous membranes. Used to make pharmaceuticals and dyes.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Thiophene reacts violently with strong oxidizing agents and concentrated nitric acid causing fire and explosion hazards [Handling Chemicals Safely 1980. p. 899]. A mixture of Thiophene and N-nitrosoacetanilide exploded at 0°C [Ber., 1887, 30, 367].
Hazard
Flammable, dangerous fire risk.
Health Hazard
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Poison by ingestion and intraperitoneal routes. Mildly toxic by inhalation and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. Explosive reaction with N-nitrosoacetanilide. Violent or explosive reaction with nitric acid. Incompatible with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of SOx.
Environmental Fate
Photolytic. A rate constant 9.70 x 10-12 cm3/molecule?sec was reported for the reaction of thiophene and OH radicals in the atmosphere at room temperature (Atkinson, 1985). Thiophene also reacts with NO3 radicals in the atmosphere at rate constants ranging from 3.2 x 10-14 (Atkinson et al., 1985) to 3.93 x 10-14 cm3/molecule?sec (Atkinson, 1991).
Purification Methods
The simplest purification procedure is to dry thiophen with solid KOH, or reflux it with sodium, and fractionally distil it through a glass-helices-packed column. More extensive treatments include an initial wash with aqueous HCl, then water, drying with CaSO4 or KOH, and passage through columns of activated silica gel or alumina. Fawcett and Rasmussen [J Am Chem Soc 67 1705 1945] washed thiophene successively with 7M HCl, 4M NaOH, and distilled water, dried with CaCl2 and fractionally distilled it. *Benzene was removed by fractional crystallisation by partial freezing, and the thiophene was degassed and sealed in Pyrex flasks. [Also a method is described for recovering the thiophene from the *benzene-enriched portion.] [Beilstein 17 H 29, 17 I 17, 17 II 35, 17 III/IV 234, 17/1 V 297.]
Thiophene Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNGENESIS CHEMSCIENCE PRIVATE LIMITED | +91-9067779401 +91-9067779401 | Maharashtra, India | 58 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| DeFINE CHEMICALS | +91-8010769889 +91-9320057099 | Maharashtra, India | 120 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Shilpa Chemspec International Pvt. Ltd. | 09820092809 | Mumbai, India | 20 | 58 | Inquiry |
| Global Chemie | 08046043260 | Mumbai, India | 162 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNGENESIS CHEMSCIENCE PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| DeFINE CHEMICALS | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Central Drug House(P) Ltd. | 58 |
| Shilpa Chemspec International Pvt. Ltd. | 58 |
| Global Chemie | 58 |
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