2-Thiophenecarboxylic acid
- CAS No.
- 527-72-0
- Chemical Name:
- 2-Thiophenecarboxylic acid
- Synonyms
- THIOPHENE-2-CARBOXYLIC ACID;thiophene-2-carboxylate;2-THENOIC ACID;2-TCA;THENOIC ACID;AKOS B022791;2-Thenoesure;2-THIOPHENIC ACID;AKOS BBS-00003739;2-Carboxythiophene
- CBNumber:
- CB1778926
- Molecular Formula:
- C5H4O2S
- Molecular Weight:
- 128.15
- MOL File:
- 527-72-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/29 13:39:17
| Melting point | 125-127 °C(lit.) |
|---|---|
| Boiling point | 260 °C(lit.) |
| Density | 1.42 |
| refractive index | 1.5160 (estimate) |
| Flash point | 259-261°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Chloroform (Slightly) |
| form | solid |
| pka | 3.49(at 25℃) |
| color | White to Off-White |
| Water Solubility | 80 g/L (20 ºC) |
| Merck | 14,9354 |
| BRN | 110150 |
| InChIKey | QERYCTSHXKAMIS-UHFFFAOYSA-N |
| LogP | 1.570 |
| CAS DataBase Reference | 527-72-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Thiophenecarboxylic acid(527-72-0) |
| EPA Substance Registry System | 2-Thiophenecarboxylic acid (527-72-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XM8330200 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2-Thiophenecarboxylic acid price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T32603 | 2-Thiophenecarboxylic acid ReagentPlus?, 99% | 527-72-0 | 25G | ₹2035.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T32603 | 2-Thiophenecarboxylic acid ReagentPlus?, 99% | 527-72-0 | 100G | ₹5250.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T0218 | 2-Thiophenecarboxylic Acid | 527-72-0 | 25G | ₹3800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T0218 | 2-Thiophenecarboxylic Acid | 527-72-0 | 100G | ₹10400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T0218 | 2-Thiophenecarboxylic Acid | 527-72-0 | 250G | ₹21400 | 2022-05-26 | Buy |
2-Thiophenecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.
Uses
2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Production Methods
Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.
Definition
ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.
Application
The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.
Purification Methods
Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]
2-Thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
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| Aventus Labs | +91-7021872517 +91-9324342304 | Maharashtra, India | 168 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Indo Amines Ltd | 58 |
| Biosyn Research Chemicals | 58 |
| SIRI LIFE SCIENCES | 58 |
| chakrachem Lifesciences | 58 |
| JSK Chemicals | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Alchem Synthon Pvt Ltd | 58 |
| PSN Medicare Private Limited | 58 |
| Aventus Labs | 58 |