Olanzapine
- CAS No.
- 132539-06-1
- Chemical Name:
- Olanzapine
- Synonyms
- ZYPREXA;OLANZAPINE FORM I;2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine, LY-170053, Zyprexa;Larmac;Oleanz;Olanzne;Integrol;Olanzapine (200 mg);2-Methyl-4-(4-Methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;Oltal
- CBNumber:
- CB6755515
- Molecular Formula:
- C17H20N4S
- Molecular Weight:
- 312.43
- MOL File:
- 132539-06-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 195°C |
|---|---|
| Boiling point | 476.0±55.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 7.78±0.20(Predicted) |
| color | yellow |
| Merck | 14,6822 |
| BRN | 7655141 |
| BCS Class | 2 |
| CAS DataBase Reference | 132539-06-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Olanzapine(132539-06-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi,Xn,F | |||||||||
| Risk Statements | 36/38-36-20/21/22-11 | |||||||||
| Safety Statements | 26-36/37-16 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ9007750 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | human,TDLo,oral,16560ug/kg/12 (16.56mg/kg),Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999. | |||||||||
| NFPA 704 |
|
Olanzapine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O1141 | Olanzapine ≥98% (HPLC) | 132539-06-1 | 10MG | ₹10110.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1825 | Olanzapine Pharmaceutical Secondary Standard; Certified Reference Material | 132539-06-1 | 1G | ₹18954.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O1141 | Olanzapine ≥98% (HPLC) | 132539-06-1 | 50MG | ₹38417.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O-024 | Olanzapine solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 132539-06-1 | 1ML | ₹8751.4 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0393 | Olanzapine min. 98.0 % | 132539-06-1 | 1G | ₹7200 | 2022-05-26 | Buy |
Olanzapine Chemical Properties,Uses,Production
Description
Zyprexa was launched in Canada, Germany, the UK and US as an antipsychotic agent. Prepared in three steps via the intermediate diazepinone, it is an atypical antipsychotic with a high affinity for dopaminergic and serotonergic receptors. Specifically, olazapine is a potent 5-HT2/D2 antagonist with anticholinergic activity. It has a greater antagonistic effect at 5-HT2a than at dopamine D2 receptors and in vivo is clozapine-like. Thus it is less likely to produce extrapyramidal side effects and does not produce any granulocytopenia. Its 10 metabolic products are all inactive.
Chemical Properties
Yellow Crystalline Powder
Uses
A serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.
Definition
ChEBI: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
General Description
Olanzapine, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Zyprexa), isa yellow crystalline solid that is essentially insoluble in water.Olanzapine orally disintegrating tablets (Zyprexa Zydis) is asolid dosage form that immediately disintegrates when exposedto saliva. This product is useful for elderly patients whohave difficulty in swallowing. An injectable form, olanzapinefor injection (Zyprexa IM), is indicated for agitation associatedwith schizophrenia or bipolar I mania. Olanzapine iscombined with fluoxetine (Symbyax) for use in depressionthat is associated with bipolar I disorder. Peak concentrationsof oral olanzapine are reached at 6 hours after oral administration,and absorption of the compound is not affected byfood.
Olanzapine binds with high affinity at DA D2, 5-HT2A,5-HT2C, 5-HT6,α1, and H1 histamine receptors. The effectsof olanzapine for the treatment of schizophrenia are presumablymediated through antagonism at D2 and 5-HT2Areceptors.The use of olanzapine in acute maniathat is associated with bipolar I disorder is thought to bemediated by antagonism at D2 and other monamine receptors.Additionally, olanzapine is postulated to produce itsmood stabilizing and antidepressant effects through 5-HT2Areceptor blockade and increased cortical DA and NE concentrations.Several studies have investigated the effectof olanzapine-induced weight gain and new-onset type 2diabetes.In a comparison study with risperidone,olanzapine was shown to have a greater risk of producingdyslipidemia and type 2 diabetes.
Clinical Use
The thienobenzodiazepine olanzapine is an effective atypical antipsychotic agent that is close in structure to clozapine but has a somewhat different neuropharmacological profile, in that it is a more potent antagonist at dopamine D2 and, especially, serotonin 5-HT2A receptors. Olanzapine is well absorbed after oral administration and is metabolized mainly by CYP1A2 to inactive metabolites, with a variable half-life of approximately 20 to 50 hours.
Olanzapine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rampex Labs Private Limited | +91 9168074433 | Telangana, India | 71 | 58 | Inquiry |
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Vision Drugs Pvt Ltd | +91 9948045450 | Telangana, India | 65 | 58 | Inquiry |
| Urantiis Pharmaceuticals Private Limited | +918790703567 | AndhraPradesh, India | 80 | 58 | Inquiry |
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Rampex Labs Private Limited | 58 |
| Cadila Pharmaceuticals Ltd | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| Vision Drugs Pvt Ltd | 58 |
| Urantiis Pharmaceuticals Private Limited | 58 |
| Jigs Chemical ltd | 58 |
| J S LABS | 58 |
| AARTIA KEM SCIENCE | 58 |
| GLP Pharma Standards | 58 |
| SNECOFRi Pvt Ltd | 58 |