2-Thiophenecarboxaldehyde
- CAS No.
- 98-03-3
- Chemical Name:
- 2-Thiophenecarboxaldehyde
- Synonyms
- THIOPHENE-2-CARBALDEHYDE;2-THIOPHENECARBOXALDEHYDE;THIOPHENE-2-ALDEHYDE;THIOPHENE-2-CARBOXALDEHYDE;2-THIOPHENECARBALDEHYDE;formylthiophene;S0508;2-Thienal;2-Theldehyde;THENALDEHYDE
- CBNumber:
- CB2488611
- Molecular Formula:
- C5H4OS
- Molecular Weight:
- 112.15
- MOL File:
- 98-03-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/15 16:45:23
| Melting point | <10°C |
|---|---|
| Boiling point | 198 °C (lit.) 75-77 °C/11 mmHg (lit.) |
| Density | 1.2 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 172 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | liquid (clear) |
| Specific Gravity | 1.2 |
| color | clear yellow |
| Odor | sulfurous |
| Odor Type | sulfurous |
| Water Solubility | insoluble |
| Sensitive | Air Sensitive |
| BRN | 105819 |
| InChIKey | CNUDBTRUORMMPA-UHFFFAOYSA-N |
| LogP | 1.020 |
| CAS DataBase Reference | 98-03-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Thiophenecarboxaldehyde(98-03-3) |
| EPA Substance Registry System | 2-Thiophenecarboxaldehyde (98-03-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-43 | |||||||||
| Safety Statements | 36/37/39-37-24-36-26 | |||||||||
| RIDADR | UN 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XM8135000 | |||||||||
| F | 9 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2-Thiophenecarboxaldehyde price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T32409 | 2-Thiophenecarboxaldehyde 98% | 98-03-3 | 25G | ₹1870 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T32409 | 2-Thiophenecarboxaldehyde 98% | 98-03-3 | 100G | ₹4690 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T0725 | 2-Thiophenecarboxaldehyde (stabilized with HQ) min. 98.0 % | 98-03-3 | 25ML | ₹2300 | 2022-05-26 | Buy |
| ALFA India | ALF-A14344-36 | Thiophene-2-carboxaldehyde, 98+% | 98-03-3 | 500g | ₹8923 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T0725 | 2-Thiophenecarboxaldehyde (stabilized with HQ) min. 98.0 % | 98-03-3 | 100ML | ₹3800 | 2022-05-26 | Buy |
2-Thiophenecarboxaldehyde Chemical Properties,Uses,Production
Description
2-Thiophenecarboxaldehyde, also known as alpha-formylthiophene or 2-thienylaldehyde, belongs to the class of organic compounds known as aryl-aldehydes. Aryl-aldehydes are compounds containing an aldehyde group directly attached to an aromatic ring. 2-Thiophenecarboxaldehyde is a sulfurous tasting compound. 2-Thiophenecarboxaldehyde has been detected, but not quantified in, asparagus (Asparagus officinalis). This could make 2-thiophenecarboxaldehyde a potential biomarker for the consumption of these foods. 2-Thiophenecarboxaldehyde is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites.
Chemical Properties
clear yellow to light brown liquid
Uses
Thiophene derivatives, introducing thenyl group into organic compounds.
Application
2-Thenaldehyde(T2A) was originally used to produce a range of antihistamines, including methapyrilene, methaphenilene, and thenalidine. However, this usage has practically disappeared. The anthelmintic pyrantel is an important outlet for T2A, enhanced by new formulations and the development of the medicinal use of pyrantel beyond the original veterinary market. An important T2A derivative is the antihypertensive eprosartan (2-thiophenepropionic acid methyl ester), which acts as a selective angiotensin II receptor antagonist. ?Other pharmaceuticals containing T2A are azosemide a diuretic, and teniposide an antineoplastic.
Definition
ChEBI: 2-Thiophenecarboxaldehyde is an aldehyde that is thiophene substituted by a formyl group at position 2. It has a role as a metabolite. It is a member of thiophenes and an aldehyde.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Synthesis
2-Thiophenecarboxaldehyde is prepared by the reaction of 2-Iodothiophene and carbon monoxide. The specific synthesis steps are as follows:
General procedure: A flask was charged with aryl iodide 1 (0.5 mmol), Pd(OAc)2 (2.4 mg, 0.01mmol), Na2CO3 (53.1 mg. 0.5 mmol), NaHCO3 (42.0 mg, 0.5 mmol), and PEG-400 (2 g) beforestandard cycles evacuation and backfilling with dry and pure carbon monoxide. Triethylsilane(162.8 μl, 1.0 mmol) was added successively. Then, the mixture was stirred at room temperaturefor the indicated time. At the end of the reaction, the reaction mixture was extracted with diethylether (3 × 10 mL). The organic phases were combined, and the volatile components wereevaporated under reduced pressure. The crude product was purified by column chromatography onsilica gel (petroleum ether / diethyl ether).
Purification Methods
Wash it with 50% HCl and distil it under reduced pressure just before use. It has UV: 234nm (hexane). The Z-oxime has m 144o, 136-138o and 142o (H2O). [Beilstein
2-Thiophenecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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