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Sodium acetate trihydrate

Sodium acetate trihydrate Structure
CAS No.
6131-90-4
Chemical Name:
Sodium acetate trihydrate
Synonyms
NaAc;SODA CAUSTIC;Sodium acetate crystal;SODIUM ACETATE 3H2O;SODIUM ACETATE, TRIHYDRATE, REAGENT (ACS)SODIUM ACETATE, TRIHYDRATE, REAGENT (ACS)SODIUM ACETATE, TRIHYDRATE, REAGENT (ACS);lnkM;abs9264;Plasmafusin;Thomaegelin;Natrii acetas
CBNumber:
CB3410262
Molecular Formula:
C2H9NaO5
Molecular Weight:
136.08
MOL File:
6131-90-4.mol
MSDS File:
SDS
Modify Date:
2024/7/14 20:44:35
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Sodium acetate trihydrate Properties

Melting point 58 °C
Boiling point >400°C
Density 1,45 g/cm3
Flash point >250°C
storage temp. Store at +5°C to +30°C.
solubility H2O: 3 M at 20 °C, clear, colorless
form Solid
color White
Odor Slight acetic acid
PH Range 8.5 - 10 at 408 g/l at 25 °C
PH 7.5-9.0 (25℃, 50mg/mL in H2O)
pka 4.76 (acetic acid)(at 25℃)
Water Solubility 762 g/L (20 ºC)
λmax λ: 260 nm Amax: ≤0.01
λ: 280 nm Amax: ≤0.01
Merck 14,8571
BRN 3732037
Stability Stable. Incompatible with strong oxidizing agents, halogens.
InChIKey AYRVGWHSXIMRAB-UHFFFAOYSA-M
LogP -0.285 (est)
CAS DataBase Reference 6131-90-4(CAS DataBase Reference)
NIST Chemistry Reference Sodium acetate trihydrate(6131-90-4)
EPA Substance Registry System Acetic acid, sodium salt, trihydrate (6131-90-4)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  1
RTECS  AJ4580000
Autoignition Temperature 607 °C
TSCA  Yes
HS Code  29152200
Toxicity LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg
NFPA 704
1
1 0

Sodium acetate trihydrate price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S8625 Sodium acetate trihydrate ReagentPlus?, ≥99.0% 6131-90-4 250G ₹3340 2022-06-14 Buy
Sigma-Aldrich(India) S8625 Sodium acetate trihydrate ReagentPlus?, ≥99.0% 6131-90-4 500G ₹5980 2022-06-14 Buy
Sigma-Aldrich(India) S8625 Sodium acetate trihydrate ReagentPlus?, ≥99.0% 6131-90-4 1KG ₹6592.43 2022-06-14 Buy
Sigma-Aldrich(India) S8625 Sodium acetate trihydrate ReagentPlus?, ≥99.0% 6131-90-4 2KG ₹8475.98 2022-06-14 Buy
Sigma-Aldrich(India) S8625 Sodium acetate trihydrate ReagentPlus?, ≥99.0% 6131-90-4 5KG ₹13650.33 2022-06-14 Buy
Product number Packaging Price Buy
S8625 250G ₹3340 Buy
S8625 500G ₹5980 Buy
S8625 1KG ₹6592.43 Buy
S8625 2KG ₹8475.98 Buy
S8625 5KG ₹13650.33 Buy

Sodium acetate trihydrate Chemical Properties,Uses,Production

Chemical Properties

Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.

Uses

Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.

Preparation

Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate.
NaOH + CH3COOH → CH3COONa + H2O
Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O

General Description

Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and 13C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.

Pharmaceutical Applications

Sodium acetate is used as part of a buffer system when combined with acetic acid in various intramuscular, intravenous, topical, ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It can be used to enhance the antimicrobial properties of formulations; it has been shown to inhibit the growth of S. aureus and E. coli, but not C. albicans in protein hydrolysate solutions. It is widely used in the food industry as a preservative. Sodium acetate has also been used therapeutically for the treatment of metabolic acidosis in premature infants, and in hemodialysis solutions.

Safety

Sodium acetate is widely used in cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes.
LD50 (rat, oral): 3.53 g/kg
LD50 (mouse, IV): 0.38 g/kg
LD50 (mouse, SC): 8.0 g/kg

storage

Sodium acetate should be stored in airtight containers.

Incompatibilities

Sodium acetate reacts with acidic and basic components. It will react violently with fluorine, potassium nitrate, and diketene.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic, and oral preparations).

References

[1] http://www.europlat.org
[2] http://www.rxlist.com/sodium-acetate-drug.htm
[3] http://cosmetics.specialchem.com
[4] http://cecri.csircentral.net/2710/1/036-96.pdf

Sodium acetate trihydrate Preparation Products And Raw materials

Raw materials

Acetic acid solution Acetic acid Sodium hydroxide Activated carbon Sodium carbonate

Preparation Products

Gardenia blue pigment Pigment Yellow 83 5-Ethyl-2-thiophenecarboxaldehyde BISPYRAZOLONE LEAD PHOSPHITE, DIBASIC
6-HYDROXY-7-METHOXYCOUMARIN Pigment Red 32 Pigment Red 13 Pigment Yellow 65 o-Anisic acid
VINYL STEARATE 3-(2-FURYL)ISOXAZOL-5-AMINE Pigment Red 175 RHODINYL ACETATE softener IS
Phenethyl acetate Sodium diacetate 8-METHOXYCOUMARIN D-alpha-Tocopheryl acetate Geranyl acetate
3-Amino-5-phenylpyrazole 2,6-Dithiopurine ACID BLUE 92 glyceryl ethercarboxylic acid salt 3,3'-Dihydroxybenzidine
6-METHOXYCOUMARIN Cefotaxime PALMITIC ACID VINYL ESTER 2-Acetyl pyrrole 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
2-AMINO-4-(4-CHLORO-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 5-METHYL-4-ISOXAZOLECARBONYL CHLORIDE 4-Hydroxy-3-methoxystyrene C. I. Pigment Red 258 7-isopropyl-4-methyloxepan-2-one
5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE 6-AMINO-5-NITROSO-3-METHYLURACIL Cephalothin sodium Coumarin 30 ISOXANTHOPTERIN
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Supplier Advantage
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Rishi Chemical Works Pvt Ltd 58
Indiana ChemPort 58
JAY CHEMICALS 58
Mahadev Pharmaceuticals 58
ALLIPO CHEMICALS 58
JSK Chemicals 58
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AVA CHEMICALS PVT LTD 58
Ultra Chemical Works 58

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Sodium acetate trihydrate Spectrum

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