1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
![1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Structure](CAS/GIF/321-64-2.gif)
- CAS No.
- 321-64-2
- Chemical Name:
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- Synonyms
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;C01453;acrine;cs12602;CS 12602;AKOS 221-09;Tacrine 321-64-2;BUTTPARK 20\04-06;Tetrahydroaminocrin
- CBNumber:
- CB7699634
- Molecular Formula:
- C13H14N2
- Molecular Weight:
- 198.26
- MOL File:
- 321-64-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
Melting point | 183.5℃ |
---|---|
Boiling point | 325.59°C (rough estimate) |
Density | 0.9827 (rough estimate) |
refractive index | 1.4400 (estimate) |
storage temp. | 4°C, away from moisture and light |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9?+-.0.20(Predicted) |
color | White to Pale Yellow |
CAS DataBase Reference | 321-64-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311+H331-H315-H319 |
Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties,Uses,Production
Description
In the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.
Uses
The current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | China | 2136 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8744 | 58 | Inquiry |
CD Chemical Group Limited | +8615986615575 | China | 20356 | 58 | Inquiry |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | China | 18424 | 58 | Inquiry |
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