Sodium acetate trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.
Verwenden
Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.
synthetische
Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate.
NaOH + CH3COOH → CH3COONa + H2O
Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O
Allgemeine Beschreibung
Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and
13C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.
Pharmazeutische Anwendungen
Sodium acetate is used as part of a buffer system when combined
with acetic acid in various intramuscular, intravenous, topical,
ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It
can be used to enhance the antimicrobial properties of formulations;
it has been shown to inhibit the growth of S. aureus and E. coli, but
not C. albicans in protein hydrolysate solutions. It is widely used
in the food industry as a preservative. Sodium acetate has also
been used therapeutically for the treatment of metabolic acidosis in
premature infants, and in hemodialysis solutions.
Sicherheit(Safety)
Sodium acetate is widely used in cosmetics, foods, and pharmaceutical
formulations, and is generally regarded as a
nontoxic and nonirritant material.
A short-term feeding study in chickens with a diet supplemented
with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if
injected intravenously, is moderately toxic by ingestion, and is an
irritant to the skin and eyes.
LD50 (rat, oral): 3.53 g/kg
LD50 (mouse, IV): 0.38 g/kg
LD50 (mouse, SC): 8.0 g/kg
Lager
Sodium acetate should be stored in airtight containers.
Inkompatibilitäten
Sodium acetate reacts with acidic and basic components. It will
react violently with fluorine, potassium nitrate, and diketene.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic,
and oral preparations).
Einzelnachweise
[1] http://www.europlat.org
[2] http://www.rxlist.com/sodium-acetate-drug.htm
[3] http://cosmetics.specialchem.com
[4] http://cecri.csircentral.net/2710/1/036-96.pdf
Sodium acetate trihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Gardenia blue pigment
2,2'-[(3,3'-Dichlor[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chlor-2,5-dimethoxyphenyl)-3-oxobutyramid]
5-Ethylthiophen-2-carbaldehyd
3,3'-Dimethyl-1,1'-diphenyl-4,4'-bi-5-pyrazolon
Tribleidioxidphosphonat
6-Hydroxy-7-methoxy-2-benzopyron
4-[[5-(Anilino)carbonyl-2-methoxyphenyl]azo]-3-hydroxy-N-phenylnaphthalin-2-carboxamid
3-Hydroxy-4-[(4-methyl-2-nitrophenyl)azo]-N-(o-tolyl)naphthalin-2-carboxamid
2-[(4-Methoxy-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramid
o-Anissure
Vinylstearat
3-(2-FURYL)ISOXAZOL-5-AMINE
Methyl-2-[[3-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-hydroxy-1-naphthyl]azo]benzoat
Rhodinylacetat
softener IS
Phenethylacetat
Natriumhydrogendi(acetat)
8-METHOXYCOUMARIN
α-Tocopherylacetat
Geranylacetat
3-Amino-5-phenylpyrazole
3,7-Dihydro-1H-purin-2,6-dithion
Trinatrium-4-hydroxy-4-(4-anilino-5-sulfonato-1-naphthylazo)naphthalin-2,7-disulfonat
glyceryl ethercarboxylic acid salt
3,3'-Dihydroxybenzidine
6-METHOXYCOUMARIN
Cefotaxime
Vinylpalmitat
1-(1H-Pyrrol-2-yl)ethan-1-on
Tacrin
2-AMINO-4-(4-CHLORO-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
5-METHYL-4-ISOXAZOLECARBONYL CHLORIDE
2-Methoxy-4-vinylphenol
C. I. Pigment Red 258
7-Isopropyl-4-methyloxepan-2-on
5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE
6-AMINO-5-NITROSO-3-METHYLURACIL
Cefalotinnatrium
7-(Diethylamino)-3-(1-methyl-1H-benzimidazol-2-yl)-2-benzopyron
2-Aminopteridin-4,7-diol
