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Valsartan

Valsartan Structure
CAS No.
137862-53-4
Chemical Name:
Valsartan
Synonyms
DIOVAN;Nisis;Valsratan;Varsartan;Tareg;CGP-48933;VALSARTAN;Valsatarn;Valsartane;L-Valsartan
CBNumber:
CB6182539
Molecular Formula:
C24H29N5O3
Molecular Weight:
435.52
MOL File:
137862-53-4.mol
MSDS File:
SDS
Modify Date:
2024/7/24 17:31:20
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Valsartan Properties

Melting point 116-117°C
Boiling point 684.9±65.0 °C(Predicted)
Density 1.212±0.06 g/cm3(Predicted)
vapor pressure 0-0Pa at 20-25℃
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
pka 3.56±0.10(Predicted)
color white to tan
optical activity [α]/D -55 to -70°, c = 1 in methanol
Water Solubility 84.99mg/L(25 ºC)
Merck 14,9916
BCS Class 2
Stability Hygroscopic
InChIKey ACWBQPMHZXGDFX-QFIPXVFZSA-N
LogP 1.2-2.8 at 25℃ and pH2.5-7
Surface tension 59.6-68.1mN/m at 10-100mg/L and 20℃
Dissociation constant 3.76-4.38 at 25℃
CAS DataBase Reference 137862-53-4(CAS DataBase Reference)
EPA Substance Registry System L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (137862-53-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H336-H361d
Precautionary statements  P201-P308+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  YV9455000
HS Code  29339900
NFPA 704
0
1 0

Valsartan price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0142 Valsartan ≥98% (HPLC) 137862-53-4 10MG ₹10879.13 2022-06-14 Buy
Sigma-Aldrich(India) SML0142 Valsartan ≥98% (HPLC) 137862-53-4 50MG ₹43527.33 2022-06-14 Buy
Sigma-Aldrich(India) PHR1315 Valsartan Pharmaceutical Secondary Standard; Certified Reference Material 137862-53-4 1G ₹9006.4 2022-06-14 Buy
TCI Chemicals (India) V0112 Valsartan 137862-53-4 1G ₹3600 2022-05-26 Buy
TCI Chemicals (India) V0112 Valsartan 137862-53-4 5G ₹6200 2022-05-26 Buy
Product number Packaging Price Buy
SML0142 10MG ₹10879.13 Buy
SML0142 50MG ₹43527.33 Buy
PHR1315 1G ₹9006.4 Buy
V0112 1G ₹3600 Buy
V0112 5G ₹6200 Buy

Valsartan Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Definition

ChEBI: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.

General Description

Valsartan, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine (Diovan), likelosartan, possesses the acidic tetrazole system, which mostlikely plays a role, similar to that of the acidic groups of angiotensinII, in binding to the angiotensin II receptor. In addition,the biphenyl system that serves to separate the tetrazolefrom the aliphatic nitrogen is still present. In addition, there isa carboxylic acid side chain in the valine moiety that alsoserves to bind to the angiotensin II receptor.

Valsartan Preparation Products And Raw materials

Raw materials

Tetrazole L-Valine methyl ester hydrochloride 4'-formylbiphenyl-2-carbonitrile Valeryl chloride Sodium cyanoborohydride
Tributyltin azide Triethylamine N-[(2′-(1-Triphenylmethyl-Tetrazole-5-Yl)Biphenyl-4-Yl]-Methyl]-N-Valeryl-L- Valine Benzyl Ester N-(4-bromobenzyl)-N-pentanoyl-L-valine 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole
Valsartan cyano analog methyl ester (S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester Valsartan Methyl Ester
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Preparation Products

Valsartan Suppliers

Global( 1001)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Cadila Pharmaceuticals Ltd +91-7069076657 +91-7069076657 Ahmedabad, India 54 58 Inquiry
AVD pharmaceuticals Pvt Ltd +919860835260 Pune, India 102 58 Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
SNECOFRi Pvt Ltd +91-9032850129 +91-9032850129 Telangana, India 404 58 Inquiry
KARPSCHEM LABORATORIES +91-7249203006 +91-7249203006 Maharashtra, India 786 58 Inquiry
Brundavan Laboratories Pvt Ltd +91-7095781199 +91-7095781199 Telangana, India 17 58 Inquiry
Supplier Advantage
GLR Innovations 58
Jigs Chemical ltd 58
Cadila Pharmaceuticals Ltd 58
AVD pharmaceuticals Pvt Ltd 58
ANWITA APIS 58
Dr. Reddy's Laboratories Ltd 58
SGMR PHARMACEUTICALS PVT LTD 58
SNECOFRi Pvt Ltd 58
KARPSCHEM LABORATORIES 58
Brundavan Laboratories Pvt Ltd 58

Related articles

Related Qustion

Valsartan Spectrum

Valsartan(137862-53-4)1HNMR

137862-53-4(Valsartan)Related Search:

Telmisartan Valsartan D9 Valsartan Benzyl Ester N2-Trityl Analog L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE L-VALINE METHYL ESTER HYDROCHLORIDE (INTERMEDIATE OF VALSARTAN)
N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-L-valine methyl ester Valsartan Benzyl Ester N1-Trityl Analog Valsartan for peak identification Valsartan for system suitability N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester
(R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate 1426129-50-1 enantioMer BOC-D-4,4'-BIPHENYLALANINE Telmisartan Impurity 10 N-NITROSO-DI-ISO-PROPYLAMINE
LCZ-696 Impurity 60 Valsartan Impurity 32 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate
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L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- Ambroxol Hydrochloride Imp.D 3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic aci (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]amine (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic aci VALSARTAN IMP C Valsartan,99%e.e. N-(1-OXOPENTYL)-N-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-L-VALINE VALSARTAN CGP-48933 VALSARTAN, MM STANDARD VALSARTAN, USP STANDARD VALSARTAN, RELATED COMPOUND A(R)-N-VALERYL-N-([2'-(1-H-TETRAZOLE)-5-YL)-BIPHENYL-4-YL]-METHYL)-VALINE USP STANDARD VALSARTAN, RELATED COMPOUND C(S)-N-VALERYL-N-([2'-(1-H-TETRAZOLE)-5-YL)-BIPHENYL-4-YL]-METHYL)-VALINE BENZYL ESTER USP STANDARD Valsartan99% N-[[(2-Cyano(1.1-Biphenyl)-4-Yl)Methyl]MethylEster]-L-Valine.Hydrochloride ValsartanC24H29N503 Valsartane (S)-2-(N-((2''-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)PENTANAMIDO)-3-METHYLBUTANOIC ACID Diovan, N-(1-Oxopentyl)-N-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-L-valine, CGP-48933 N-(1-N.PENTANOYL)-N-[[2''-(1H-TETRAZOL-5-YL)[1'',1- BIPHENYL]-4-YL]METHYL]-L-VALINE/VALSARTAN L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI) Tareg 3-methyl-2-[pentanoyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid Valsartan Related Compound A (10 mg) ((R)-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl)-valine) N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'- N-(1-Oxopentyl)-N-[[2’-(1H-tetrazol-5-y1)[1，1'-biphenyl]-4-y1]methyl]-L-valine N-(1-Oxopentyl)-N-[[2'-(2H-tetrazo-5-yl) Valsartan (350 mg)G0F0650.997mg/mg(an) Valsartan (350 mg) 3-Methyl-2-[pentanoy L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)pentanaMido)-3-Methylbutanoic acid Valsartan API Valsartan (>99% pure) N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine (2S)-3-Methyl-2-[N-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)pentanaMido]butanoic acid L-Valsartan 2-(N-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)pentanaMido)-3-Methylbutanoic acid ((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-L-valine N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3 -methylbutanoic acid (S)-N-[p-(o-1H-Tetrazol-5-ylphenyl)benzyl]-N-valeryl-L-valine (S)-2-(N-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid Valsartan, 99%, a nonpeptide angiotensin II AT1 receptor antagonist Valsartan 3-Methyl-2-[pentanoyl-[[4- [2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl] amino]-butanoic acid Valsartan Manufacturer (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid Valsatarn Valsartan Impurity 18 (S)-2-(N-((2'-(1H-tetrazol-5-yl) Valsartan CRS Valsartan RS Valsartan for peak identification CRS Valsartan for system suitability CRS N-Valeryl-N-[2'-(5-tetrazolyl)biphenyl-4-ylmethyl]-L-valine N-((2-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valine Valsartan USP/EP/BP