Losartan
- CAS No.
- 114798-26-4
- Chemical Name:
- Losartan
- Synonyms
- LOS;dup89;LOSARTAN;Compound 89;Losartan（base）;Losartan (DUP 89);nyl)-4-yl)methyl)-;Losartan (DuP-753);Losartan USP/EP/BP;Losartan - Bio-X ?
- CBNumber:
- CB8120081
- Molecular Formula:
- C22H23ClN6O
- Molecular Weight:
- 422.91
- MOL File:
- 114798-26-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 183-184 C |
|---|---|
| Boiling point | 682.0±65.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| vapor pressure | 0.002Pa at 20℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5-6(at 25℃) |
| color | White to Off-White |
| Water Solubility | 4.8mg/L at 20℃ |
| LogP | 1.1 at 20℃ |
| CAS DataBase Reference | 114798-26-4(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (114798-26-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H360FD-H362 |
| Precautionary statements | P202-P260-P263-P280-P302+P352-P308+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| Hazardous Substances Data | 114798-26-4(Hazardous Substances Data) |
Losartan Chemical Properties,Uses,Production
Uses
Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Definition
ChEBI: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
General Description
Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.
Losartan Preparation Products And Raw materials
Raw materials
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Global( 294)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vijayasri Organics Private Limited | +91-9848990113 +91-9848990113 | Telangana, India | 43 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 159 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| Sainor Life Sciences Pvt Ltd | +919542990009 | AndhraPradesh, India | 13 | 58 | Inquiry |
| Divis Laboratories Ltd | +91-4066966413 +91-4066966413 | Hyderabad, India | 34 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| PSN Medicare Private Limited | +91-9030090313 +91-7702388996 | Telangana, India | 82 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Lavybens Pharma | +91-8790466757 +91-8790466756 | Telangana, India | 80 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vijayasri Organics Private Limited | 58 |
| J S LABS | 58 |
| Viyash Life Sciences Pvt Ltd | 58 |
| Sainor Life Sciences Pvt Ltd | 58 |
| Divis Laboratories Ltd | 58 |
| Lakshmi Farmachem | 58 |
| PSN Medicare Private Limited | 58 |
| Chempifine Chemicals | 58 |
| Ralington Pharma | 58 |
| Lavybens Pharma | 58 |
114798-26-4(Losartan)Related Search:
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2-Butyl-4-chloro-5-(hydroxymethyl)-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole
Compound 89
2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph
2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
dup89
nyl)-4-yl)methyl)-
2-butyl-4-chloro-1-[p-(o-1h-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol
LOSARTAN
LosartanC22H23C1N60
1h-imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1h-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-
(1-((2-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)-2-BUTYL-4-CHLORO-1H-IMIDAZOL-5-YL)METHANOL (LOSARTAN)
2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-y1)[1，1'-biphenyl]’4’y1]methyl]-1H-imidazole-5-methanol
2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-methanol
(2-BUTYL-4-CHLORO-1-{[2'-(1H-TETRAZOL-5-YL)-4-BIPHENYLYL]METHYL}-1H-IMIDAZOL-5-YL)METHANOL
Losartan (DuP-753)
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanol
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Losartan Potassium Form-I
Losartan USP/EP/BP
2-Butyl-4-chloro-1[[(2'-(1 H-tetrazole-5-yl) (1,1'-biphenyl)-4yl]methyl]-1H imidazole-5-methanol (Losartan)
Losartan (DUP 89)
LosartanQ: What is
Losartan Q: What is the CAS Number of
Losartan Q: What is the storage condition of
Losartan Q: What are the applications of
Losartan
LOS
Benzaldehyde,3,4-dichloro-6-hydroxy-
(3-oxo-1lambda3,2-benziodoxol-5-yl)acetate
Losartan（base）
2 butyl 4-chloro-1[(2-(1H-tetrazole-5[1,1 biphenyl]-4-yl]methyl]-H imidazole-5methanol
(1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
Losartan in methanol
(1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
Losartan, 10 mM in DMSO
2-Butyl-4-Chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-
biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
Losartan - Bio-X ?
114798-26-4
C22H23ClN6O
Isotopically Labeled Pharmaceutical Reference Standard