1-Methylimidazole
- CAS No.
- 616-47-7
- Chemical Name:
- 1-Methylimidazole
- Synonyms
- N-METHYLIMIDAZOLE;1-methyl-1h-imidazole;MIM;MeIm;methyl imidazole;1H-Imidazole, 1-methyl-;N-methylimidazole (1-methylimidazole);1-methylmidazole;N-methyl midazole;N-methyl glyoxaline
- CBNumber:
- CB1316726
- Molecular Formula:
- C4H6N2
- Molecular Weight:
- 82.1
- MOL File:
- 616-47-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/8 18:06:34
| Melting point | −60 °C(lit.) |
|---|---|
| Boiling point | 198 °C(lit.) |
| Density | 1.03 g/mL at 25 °C(lit.) |
| vapor pressure | 0.4 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 198 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 6.95(at 25℃) |
| Specific Gravity | 1.031 |
| color | Clear colorless to yellow |
| PH | 9.5-10.5 (50g/l, H2O, 20℃) |
| PH Range | 9.5 - 11.5 at 100 g/l at 20 °C |
| explosive limit | 2.7-15.7%(V) |
| Water Solubility | Miscible with water. |
| Sensitive | Hygroscopic |
| BRN | 105197 |
| Stability | Stable, but moisture sensitive. Incompatible with acids, acid anhydrides, strong oxidizing agents, moisture, carbon dioxide, acid chlorides. |
| InChIKey | MCTWTZJPVLRJOU-UHFFFAOYSA-N |
| LogP | -0.19 at 25℃ |
| CAS DataBase Reference | 616-47-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Imidazole, 1-methyl-(616-47-7) |
| EPA Substance Registry System | 1H-Imidazole, 1-methyl- (616-47-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H314 | |||||||||
| Precautionary statements | P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,Xn,F,T | |||||||||
| Risk Statements | 21/22-34-19-11-20/21/22-52/53-24-22-40-37-21 | |||||||||
| Safety Statements | 26-36-45-1/2-36/37/39-16-33-29-61 | |||||||||
| RIDADR | UN 3267 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NI7000000 | |||||||||
| F | 3-10 | |||||||||
| Autoignition Temperature | 977 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332990 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1144 mg/kg LD50 dermal Rabbit > 400 - < 640 mg/kg | |||||||||
| NFPA 704 |
|
1-Methylimidazole price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M50834 | 1-Methylimidazole ReagentPlus?, 99% | 616-47-7 | 100G | ₹1960 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 25ML | ₹3620 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M50834 | 1-Methylimidazole ReagentPlus?, 99% | 616-47-7 | 500G | ₹7980 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 100ML | ₹8710 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 1L | ₹40520 | 2022-06-14 | Buy |
1-Methylimidazole Chemical Properties,Uses,Production
Chemical Properties
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colorless to yellow liquid, with an amine-like odor. It is miscible with water. N-methylimidazole is an important raw material for the synthesis of pharmaceutical intermediates, used in the preparation of losartan, nizofenone, 1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride and naphazoline hydrochloride, etc. It is also used as a specialty solvent, a base, and as a precursor to some ionic liquids.
Uses
1-Methylimidazole is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate. It is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.
Uses
1-Methylimidazole is an aprotic solvent. It is a derivative of imidazole used in the production of pharmaceuticals, pesticides, ion exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It can also be used as a catalyst for the manufacture of polyurethane and a curing agent for epoxy resins. For example, when 1-methylimidazole is added to an aqueous diethylenetriamine (DETA) solution, high CO2 loading can be achieved through phase separation of the absorbent during CO2 absorption[1].
Preparation
1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine.
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
Definition
ChEBI: 1-methyl-1H-imidazole is a 1H-imidazole having a methyl substituent at the N-1 position. It is a metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.
General Description
This product has been enhanced for catalysis. 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins.
Purification Methods
Dry it with sodium metal and then distil it. Store it at 0o under dry argon. The picrate has m 159.5-160.5o (from H2O). [Beilstein 23 III/IV 568.]
References
[1] You J, et al. Effect of 1-Methylimidazole on CO2 Absorption by Diethylenetriamine (DETA) Aqueous Solutions. Chemical Engineering & Technology, 2017; 40: 2238-2242.
1-Methylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | +91-8619349510 +91-8619349510 | Bangalore, India | 82 | 58 | Inquiry |
| BTC pharm India | +918790379245 | Telangana, India | 145 | 58 | Inquiry |
| AARTI DRUGS LIMITED | +91 22 2401 9025 | New Delhi, India | 22 | 58 | Inquiry |
| ASM Organics | 91-9866122393 | Andhra Pradesh, India | 1188 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Vardhaman P Golechha | 58 |
| JSK Chemicals | 58 |
| KARPSCHEM LABORATORIES | 58 |
| BASF India Limited | 58 |
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | 58 |
| BTC pharm India | 58 |
| AARTI DRUGS LIMITED | 58 |
| ASM Organics | 58 |
| HiMedia Laboratories | 58 |
Related articles
- 1-Methylimidazole: An Overview
- 1-Methylimidazole, also known as N-methylimidazole, is a heterocyclic organic compound with the molecular formula C4H6N2.
- Jul 12，2024