1-Bromobutane
- CAS No.
- 109-65-9
- Chemical Name:
- 1-Bromobutane
- Synonyms
- N-BUTYL BROMIDE;bromo butane;BUTYL BROMIDE;n-bromobutane;Butane,1-bromo-;n-C4H9Br;1-Brombutan;1-BROMOBUTANE;1-bromo-butan;n-Butylbromid
- CBNumber:
- CB2852782
- Molecular Formula:
- C4H9Br
- Molecular Weight:
- 137.02
- MOL File:
- 109-65-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/30 14:17:11
| Melting point | -112 °C |
|---|---|
| Boiling point | 100-104 °C(lit.) |
| Density | 1.276 g/mL at 25 °C(lit.) |
| vapor density | 4.7 (vs air) |
| vapor pressure | 150 mm Hg ( 50 °C) |
| refractive index |
n |
| Flash point | 23 °C |
| storage temp. | Store below +30°C. |
| solubility | 0.6g/l |
| form | Liquid |
| color | Clear colorless to light yellow |
| Odor | characteristic odor |
| explosive limit | 2.8-6.6%, 100°F |
| Water Solubility | 0.608 g/L (30 ºC) |
| Merck | 14,1553 |
| BRN | 1098260 |
| Dielectric constant | 7.1600000000000001 |
| Stability | Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | MPPPKRYCTPRNTB-UHFFFAOYSA-N |
| LogP | 2.75 |
| CAS DataBase Reference | 109-65-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Butane, 1-bromo-(109-65-9) |
| EPA Substance Registry System | 1-Bromobutane (109-65-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H315-H319-H335-H411 | |||||||||
| Precautionary statements | P210-P273-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xi,N | |||||||||
| Risk Statements | 11-36/37/38-51/53-10 | |||||||||
| Safety Statements | 16-26-60-37/39 | |||||||||
| RIDADR | UN 1126 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | EJ6225000 | |||||||||
| Autoignition Temperature | 509 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29033036 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2761 mg/kg | |||||||||
| NFPA 704 |
|
1-Bromobutane price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B59497 | 1-Bromobutane ReagentPlus?, 99% | 109-65-9 | 25G | ₹2100.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B59497 | 1-Bromobutane ReagentPlus?, 99% | 109-65-9 | 500G | ₹2229.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B59497 | 1-Bromobutane ReagentPlus?, 99% | 109-65-9 | 1KG | ₹4373.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B59497 | 1-Bromobutane ReagentPlus?, 99% | 109-65-9 | 2.5KG | ₹4514.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.01602 | 1-Bromobutane for synthesis | 109-65-9 | 100ML | ₹3000 | 2022-06-14 | Buy |
1-Bromobutane Chemical Properties,Uses,Production
Chemical Properties
1-bromobutane appears as a clear colorless to slightly yellow liquid with aroma. Flash point 65°F. Denser than water and insoluble in water, soluble in organic solvents such as alcohol, ether and chloroform.Vapors heavier than air.
Uses
1-Bromobutane is used as an intermediate in organic synthesis and as a solvent for cleaning and degreasing. It acts as an alkylating agent as well as to prepare organometallic compounds such as n-butyllithium. It is also involved in the synthesis of procaine and tetracaine. It reacts with magnesium metal to prepare the Grignard reagent, which is used to form carbon-carbon bonds.
Application
1-Bromobutane may be used as a derivatization reagent for multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups) of amino acids to improve hydrophobicities and basicities of the amino acids. It may also be used as an internal standard for the quantification of 1- and 2-bromopropane in human urine by headspace gas chromatography.
General Description
1-Bromobutane, an alkyl halide, is an alkylating agent. Its rotational constants, nuclear quadrupole constants and centrifugal distortion constants have been stated based on microwave spectral data. The rate coefficient for the reaction of 1-bromobutane with hydrogen atoms has been reported to be 2.4±1.2x1010cm3mol-1s-1.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
1-Bromobutane is incompatible with strong bases and oxidizers [USCG, 1999].
Hazard
Flammable, dangerous fire risk.
Health Hazard
Irritating to the eyes, nose, throat, and upper respiratory tract. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Irritating to the skin.
Safety Profile
Moderately toxic by intraperitoneal route. Mddly toxic by inhalation. Dangerous fire hazard when exposed to heat, flame, or oxidizers. Violent reaction with bromobenzene + sodium above 30℃. Can react with oxidizing materials. To fight fire, use CO2, dry chemical, mist or spray. See also BROMIDES.
Synthesis
1-bromobutane is a primary alkyl halide (primary alkyl) and therefore it is produced from bimolecular nucleophilic substitution reactions (Sn2).
The preparation method of 1-bromobutane is as follows: stirring n-butanol, sodium bromide, water and sulfuric acid evenly, heating under reflux for 3 hours, steaming out the crude bromobutane, washing with water, treating with cold concentrated sulfuric acid, and distilling to obtain the finished product.
Reaction equation: CH3CH2CH2CH2OH+NaBr+H2SO4→CH3CH2CH2CH2Br+Na2SO4+H2O
This halide is easily prepared by reacting butan-1-ol (primary alcohol) with sodium bromide solution and excess of concentrated sulfuric acid. The reaction between sodium bromide and sulphuric acid origins hydrobromic acid.
Shipping
UN1126 & UN23391- & 2-Bromobutane, Hazard Class: 3; Labels: 3—Flammable liquid.
Purification Methods
Wash the bromide with conc H2SO4, water, 10% Na2CO3 and again with H2O. Dry it over CaCl2, CaSO4 or K2CO3, and distil it. Redistil it after drying with P2O5, or pass it through two columns containing 5:1 silica gel/Celite mixture and store it with freshly activated alumina. [Beilstein 1 IV 258.]
Incompatibilities
Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May accumulate static electrical charges and cause ignition of its vapors.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed
1-Bromobutane Preparation Products And Raw materials
Raw materials
Preparation Products
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| PACIFIC ORGANICS PVT LTD | +91 9322467890 | Maharashtra, India | 51 | 58 | Inquiry |
| MAISURIYA PHARMA SOLUTIONS | +91 9870085570 | Gujarat, India | 65 | 58 | Inquiry |
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| Bhavika Chemicals Corporation | +91-9867153307 +91-9867153307 | Maharashtra, India | 31 | 58 | Inquiry |
| Delta Finochem Pvt Ltd | +919923159574 | Maharashtra, India | 67 | 58 | Inquiry |
| Neogen Chemicals Ltd | +91-9619496467 +91-8657984687 | Maharashtra, India | 56 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PACIFIC ORGANICS PVT LTD | 58 |
| MAISURIYA PHARMA SOLUTIONS | 58 |
| AD Pharmachem Pvt Ltd | 58 |
| THE MOLECULEZ | 58 |
| ARISTO INDUSTRIES PVT LTD | 58 |
| JSK Chemicals | 58 |
| SHRI LAXMI CHEMICALS | 58 |
| Bhavika Chemicals Corporation | 58 |
| Delta Finochem Pvt Ltd | 58 |
| Neogen Chemicals Ltd | 58 |
Related articles
- Synthesis of 1-Bromobutane
- 1-Bromobutane is easily prepared by reacting butan-1-ol (primary alcohol) with sodium bromide solution and excess of concentra....
- Jul 29，2024
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