n-Butyllithium
- CAS No.
- 109-72-8
- Chemical Name:
- n-Butyllithium
- Synonyms
- N-BULI;BUTYLLITHIUM;Lithiumn-butyl;n-ButyllithiuM(BULI);ButyllithiuminhexaneM;n-Butyllithium, 1.6M solution in hexanes;butyl-lithiu;LITHIUM-1-BUTANIDE;Butyllithium solution;N-butyl lithium Solution
- CBNumber:
- CB9702303
- Molecular Formula:
- C4H9Li
- Molecular Weight:
- 64.06
- MOL File:
- 109-72-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/22 16:02:48
| Melting point | -95 °C |
|---|---|
| Boiling point | 80 °C |
| Density | 0.68 g/mL at 20 °C |
| Flash point | 10 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with diethyl ether and cyclohexane. |
| form | liquid |
| color | yellow |
| Specific Gravity | 0.695 |
| Odor | Odor of the solvent |
| Water Solubility | vigorous reaction |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 1209227 |
| Exposure limits |
ACGIH: TWA 50 ppm (Skin) OSHA: TWA 500 ppm(1800 mg/m3) NIOSH: IDLH 1100 ppm; TWA 50 ppm(180 mg/m3) |
| LogP | 1.25-2.31 |
| CAS DataBase Reference | 109-72-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Butyl lithium(109-72-8) |
| EPA Substance Registry System | Lithium, butyl- (109-72-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |      GHS02,GHS05,GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H250-H261-H304-H314-H336-H361f-H373-H411-H260-H361d-H410-H252-H318-H332-H401-H361 | |||||||||
| Precautionary statements | P210-P222-P231+P232-P261-P273-P422-P223-P370+P378-P280-P301+P310-P302+P334-P303+P361+P353-P304+P340+P310-P305+P351+P338-P331-P201-P301+P310a-P405-P422a-P501a-P262 | |||||||||
| Hazard Codes | F,C,N | |||||||||
| Risk Statements | 14/15-17-34-48/20-51/53-62-65-67-63-35-11-15-50/53-66 | |||||||||
| Safety Statements | 6-9-16-26-36/37/39-45-61-62-6A-46-43B-43-60-33-29-5 | |||||||||
| RIDADR | UN 3399 4.3/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29319090 | |||||||||
| Toxicity | There is little toxicity data available for the butyllithiums; for data on ether and hydrocarbon solvents, see the appropriate LCSSs. | |||||||||
| NFPA 704 |
|
n-Butyllithium price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 302120 | n-Butyllithium solution 2.0?M in cyclohexane | 109-72-8 | 4X25ML | ₹10218.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 302120 | n-Butyllithium solution 2.0?M in cyclohexane | 109-72-8 | 4X25ML | ₹10218.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.18874 | Butyllithium (15% solution in n-hexane) for synthesis | 109-72-8 | 500ML | ₹13290.01 | 2022-06-14 | Buy |
| Sigma-Aldrich | 302120 | n-Butyllithium solution 2.0?M in cyclohexane | 109-72-8 | 800ML | ₹31208.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 302120 | n-Butyllithium solution 2.0?M in cyclohexane | 109-72-8 | 800ML | ₹31208.48 | 2022-06-14 | Buy |
n-Butyllithium Chemical Properties,Uses,Production
Chemical Properties
n-Butyllithium is a colorless crystalline solid or clear yellow solution. Due to its high reactivity and extreme solubility, even in its impurities, it is commonly thought to be a viscous liquid.
Uses
n-Butyllithium is used as a polymerization initiator in the production of elastomers like polybutadiene and styrene- butadiene- styrene. As a strong base, it is utilized in the synthesis of organic compounds. It undergoes thermal decomposition to prepare 1-butene.
Preparation
Industrially, n-butyllithium is produced by the
reaction of n-butyl chloride with lithium metal dispersion in various hydrocarbon solvents.
Hexane is the most commonly used solvent. Up to one-half of the lithium is replaced with
sodium in order to lower the cost of the butyllithium and increase the reactivity of the dispersion.
The reaction is carried out below the boiling point of the solvent.
The laboratory procedure is essentially the same except that pentane and diethyl ether
are two of the more popular solvents. The preparation runs smoothly in ether at lower
temperatures but the product must either be used immediately or kept refrigerated due to
the rapid cleavage of ether by n-butyllithium.
Flammability and Explosibility
The risk of fire or explosion on exposure of butyllithium solutions to the atmosphere depends on the identity of the organolithium compound, the nature of the solvent, the concentration of the solution, and the humidity. t-Butyllithium solutions are the most pyrophoric and may ignite spontaneously on exposure to air. Dilute solutions (1.6 M, 15% or less) of n-butyllithium in hydrocarbon solvents, although highly flammable, have a low degree of pyrophoricity and do not spontaneously ignite. Under normal laboratory conditions (25 °C, relative humidity of 70% or less), solutions of -20% concentration will usually not ignite spontaneously on exposure to air. More concentrated solutions of n-butyllithium (50 to 80%) are most dangerous and will immediately ignite on exposure to air. Contact with water or moist materials can lead to fires and explosions, and the butyllithiums also react violently with oxygen.
storage
In particular, butyllithium should be stored and handled in areas free of ignition sources, and containers of butyllithium should be stored under an inert atmosphere. Work with butyllithium should be conducted in a fume hood under an inert gas such as nitrogen or argon. Safety glasses, impermeable gloves, and a fire-retardant laboratory coat are required.
Incompatibilities
The butyllithiums are extremely reactive organometallic compounds. Violent explosions occur on contact with water with ignition of the solvent and of the butane produced. t-Butyllithium will ignite spontaneously in air. The butyllithiums ignite on contact with water, carbon dioxide, and halogenated hydrocarbons. The butyllithiums are incompatible with acids, halogenated hydrocarbons, alcohols, and many other classes of organic compounds.
Waste Disposal
Excess butyllithium solution can be destroyed by dilution with hydrocarbon solvent to a concentration of
approximately 5 wt %, followed by gradual addition to water with vigorous stirring under an inert
atmosphere. Alternatively, the butyllithium solution can be slowly poured (transfer by cannula for s- or tbutyllithium)
into a plastic tub or other container of powdered dry ice.
The residues from the above procedures and excess butyllithium should be placed in an appropriate
container, clearly labeled, and handled according to your institution's waste disposal guidelines.
n-Butyllithium Preparation Products And Raw materials
Raw materials
Preparation Products
1of8
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| Oceanic Pharmachem Pvt Ltd | +91-91-2242128600 +91-2242128600 | Maharashtra, India | 33 | 58 | Inquiry |
| ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| VASISTA LIFE SCIENCES PRIVATE LIMITED | +91-04029554774 +91-9010855544 | Hyderabad, India | 153 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Symax Laboratories | +91-9666218808 +91-9866210888 | Telangana, India | 2 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Ortin Laboratories Limited | +91-9241566560 +91-9241566560 | Hyderabad, India | 31 | 58 | Inquiry |
| Organo Metallics | +91-9391016448 +91-9705345345 | Telangana, India | 32 | 58 | Inquiry |
| Sri Neelima Laboratories | +91-7981733602 +91-9849736989 | Telangana, India | 205 | 58 | Inquiry |
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