Butyl isocyanate
- CAS No.
- 111-36-4
- Chemical Name:
- Butyl isocyanate
- Synonyms
- N-BUTYL ISOCYANATE;1-Isocyanatobutane;BIC;ISOCYANIC ACID BUTYL ESTER;n-bic;n-C4H9NCO;Butylisocyanat;Butyl isocyate;BUTYL ISOCYANATE;ISOCYANATOBUTANE
- CBNumber:
- CB8153607
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MOL File:
- 111-36-4.mol
- Modify Date:
- 2024/4/9 9:20:22
| Melting point | 85.5℃ |
|---|---|
| Boiling point | 115 °C(lit.) |
| Density | 0.88 g/mL at 25 °C(lit.) |
| vapor density | 3 (vs air) |
| vapor pressure | 10.6 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 64 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Colorless |
| Sensitive | Moisture Sensitive |
| Merck | 13,1574 |
| BRN | 773917 |
| Exposure limits | No exposure limit is set for this compound. On the basis of its low inhalation toxicity, a TLV-TWA value of 8 mg/m3 (2 ppm) can be safely ascribed. |
| InChIKey | HNHVTXYLRVGMHD-UHFFFAOYSA-N |
| CAS DataBase Reference | 111-36-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Butane, 1-isocyanato-(111-36-4) |
| EPA Substance Registry System | Butyl isocyanate (111-36-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302-H314-H317-H330-H334-H412 | |||||||||
| Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,T+ | |||||||||
| Risk Statements | 11-21/22-26-34-37-42/43 | |||||||||
| Safety Statements | 23-26-28-36/37/39-45 | |||||||||
| RIDADR | UN 2485 6.1/PG 1 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NQ8250000 | |||||||||
| F | 10-19-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29291090 | |||||||||
| Toxicity | LC50 (4hr) in male, female rats (mg/m3): 60, 55 by inhalation (Pauluhn, Eben) | |||||||||
| NFPA 704 |
|
Butyl isocyanate price More Price(2)
Butyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
Colorless to faintly yellow liquid
Uses
n-Butyl isocyanate is used as an acylatingagent in the Friedel–Crafts reaction to produce amide.
Definition
ChEBI: An isocyanate having a butyl group attached to the nitrogen.
General Description
A clear, colorless liquid with a pungent odor. Flash point 68°F. Very toxic by ingestion, and may also be toxic by skin absorption and inhalation. Vapors heavier than air. Less dense than water and insoluble in water. Produces toxic oxides of nitrogen during combustion.
Air & Water Reactions
Highly flammable. Extremely slow decomposition by water. Less dense than water and insoluble in water.
Reactivity Profile
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969].
Hazard
Strong irritant to eyes and skin.
Health Hazard
n-Butyl isocyanate exhibits low inhalationtoxicity and relatively higher oral toxicity.This is in contrast to the aromatic isocyanates. The toxic effects are nausea, dyspnea, insomnia, coughing, and chest pain.Such symptoms, however, are much lessmarked than those of methyl isocyanate.
LC50 value, inhalation (mice): 680 mg/m3
LD50 value, oral (mice): 150 mg/kg
There is no report of any carcinogenic orteratogenic study of this compound.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety Profile
A poison by ingestion and intravenous routes. Mddly toxic by inhalation. A powerful irritant to eyes, skin, and mucous membranes. A flammable liquid. See also CYANATES and NITROGEN MONOXIDE.
Potential Exposure
N-Butyl isocyanate is used as a reagent in organic synthesis; used as intermediates in production of pharmaceuticals, carbamate and urea insecticides, and fungicides. It is also used in the production of sulfonylurea antidiabetic drugs
Shipping
UN2485 n-Butyl isocyanate, Hazard Class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 3—Flammable liquid. Hazard, Inhalation Hazard Zone B. PGI.
Incompatibilities
Vapor may form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Contact with metals may evolve flammable hydrogen gas. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors
Waste Disposal
Dispose of contents and container to an approved waste disposal plant. Use a licensed professional waste disposal service to dispose of this material. Caution: this chemical is highly flammable with a low flash point (,20C). Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Butyl isocyanate Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Paushak Limited | +91-2653007932 +91-9727736899 | Vadodara, India | 59 | 58 | Inquiry |
| Innovative Labs | +91-9885794886 +91-9885794886 | Telangana, India | 219 | 58 | Inquiry |
| N SHASHIKANT & CO. | +91-8048077556 | Mumbai, India | 83 | 58 | Inquiry |
| Govind Malav & Company | 08068441030Ext 523 | Madhya Pradesh, India | 1 | 58 | Inquiry |
| Saanvi Corp | 08048962006 | Mumbai, India | 108 | 58 | Inquiry |
| Shree Ganesh Trading | 08069033845Ext 726 | Maharashtra, India | 2 | 58 | Inquiry |
| SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
| siya | 08048372319Ext 685 | Uttar Pradesh, India | 2 | 58 | Inquiry |
| Rai Innotech Polymers Private Limited | 08048372816Ext 512 | Delhi, India | 1 | 58 | Inquiry |
| Shri Ganesh Traders | 08048603802 | Madhya Pradesh, India | 1 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Paushak Limited | 58 |
| Innovative Labs | 58 |
| N SHASHIKANT & CO. | 58 |
| Govind Malav & Company | 58 |
| Saanvi Corp | 58 |
| Shree Ganesh Trading | 58 |
| SREE SYNERIC LAB | 58 |
| siya | 58 |
| Rai Innotech Polymers Private Limited | 58 |
| Shri Ganesh Traders | 58 |
Related articles
- Butyl Isocyanate: A Versatile Chemical with Broad Applications
- Butyl isocyanate, a chemical compound known for its reactive nature, plays a pivotal role in various industrial applications.
- Apr 9，2024
- Butyl isocyanate: activities, toxicity and applications
- Butyl isocyanate exhibits strong inhibition on yeast respiration and has diverse applications in pharmaceuticals, pesticides, ....
- Oct 11，2023
- What is Butyl isocyanate?
- Butyl isocyanate is the important raw material or intermediate that has widely applied in the synthesis of pharmaceutical, pe....
- Feb 19，2020