Methyl isothiocyanate
- CAS No.
- 556-61-6
- Chemical Name:
- Methyl isothiocyanate
- Synonyms
- MIT;isothiocyanatomethane;MIC;MENCS;CH3NCS;MITC;MTC;TRK;TRKA;NTRK1
- CBNumber:
- CB6455336
- Molecular Formula:
- C2H3NS
- Molecular Weight:
- 73.12
- MOL File:
- 556-61-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 30-34 °C(lit.) |
|---|---|
| Boiling point | 117-118 °C(lit.) |
| Density | 1.069 g/mL at 25 °C(lit.) |
| vapor pressure | 21 mm Hg ( 20 °C) |
| refractive index | nD37 1.5258 |
| FEMA | 4426 | METHYL ISOTHIOCYANATE |
| Flash point | 90 °F |
| storage temp. | 2-8°C |
| solubility | H2O: slightly soluble |
| form | Low Melting Solid |
| color | White to pale yellow |
| Odor | at 0.01 % in propylene glycol. pungent mustard horseradish |
| Odor Type | pungent |
| biological source | rabbit |
| Water Solubility | 7.6 g/L |
| Sensitive | Moisture Sensitive |
| Merck | 14,6092 |
| JECFA Number | 1884 |
| BRN | 605319 |
| Specific Activity | 19-25nmol/min·mg |
| Stability | Stable. Incompatible with strong oxidizing agents, alcohols, strong bases, amines. |
| InChIKey | LGDSHSYDSCRFAB-UHFFFAOYSA-N |
| LogP | 1.3 at 20℃ |
| CAS DataBase Reference | 556-61-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, isothiocyanato-(556-61-6) |
| EPA Substance Registry System | Methyl isothiocyanate (556-61-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H310+H330-H314-H317-H335-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 23/25-34-43-50/53 | |||||||||
| Safety Statements | 36/37-38-45-60-61 | |||||||||
| RIDADR | UN 2477 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PA9625000 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29309090 | |||||||||
| Hazardous Substances Data | 556-61-6(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek) | |||||||||
| NFPA 704 |
|
Methyl isothiocyanate price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ALFA India | ALF-L19464-09 | Methyl isothiocyanate, polymer-supported, 1.5-1.9 mmol/g on polystyrene | 556-61-6 | 10g | ₹27076 | 2022-05-26 | Buy |
| ALFA India | ALF-L19464-06 | Methyl isothiocyanate, polymer-supported, 1.5-1.9 mmol/g on polystyrene | 556-61-6 | 5g | ₹15293 | 2022-05-26 | Buy |
| ALFA India | ALF-L19464-03 | Methyl isothiocyanate, polymer-supported, 1.5-1.9 mmol/g on polystyrene | 556-61-6 | 1g | ₹4348 | 2022-05-26 | Buy |
| ALFA India | ALF-A11757-36 | Methyl isothiocyanate, 98% | 556-61-6 | 500g | ₹7556 | 2022-05-26 | Buy |
| ALFA India | ALF-A11757-22 | Methyl isothiocyanate, 98% | 556-61-6 | 100g | ₹2267 | 2022-05-26 | Buy |
Methyl isothiocyanate Chemical Properties,Uses,Production
Description
Methyl iso thio cyanate is the organo sulfur compound with the formula CH3N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.
Chemical Properties
Methyl isothiocyanate is a crystalline solid. Horseradish, acrid odor.
Occurrence
Reported found in horseradish.
Uses
Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river
Application
Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.
Definition
ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.
Reactions
A characteristic reaction is with amines to give methyl thioureas:
CH3NCS + R2NH → R2NC(S)NHCH3
Other nucleophiles add similarly.
General Description
A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.
Air & Water Reactions
Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.
Reactivity Profile
Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.
Hazard
Toxic by ingestion, strong irritant to eyesand skin.
Health Hazard
Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.
Fire Hazard
(Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.
Safety
MITC is a dangerous lachrymator as well as being poisonous.
Potential Exposure
It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi, insects, and nematodes.
Environmental Fate
Soil. Though no products were reported, the reported half-life in soil is <14 days
(Worthing and Hance, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to
decomposition (Sax and Lewis, 1987).
Metabolic pathway
Methyl isothiocyanate is slowly decomposed in pure water, forming methylamine. It is metabolised in rats to the mercapturate via the glutathione conjugate which serves as a potential source of methyl isothiocyanate. Methyl isothiocyanate is reactive with cellular thiols and amines and its toxicity is associated with these reactions.
Shipping
UN2477 Methyl isothiocyanate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B.
Incompatibilities
Dust may form explosive mixture with air. Reacts with water, releasing carbon dioxide and methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, strong bases, amines, water, heat and cold. Attacks iron, zinc and other metals
Waste Disposal
In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office
Methyl isothiocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1817 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| Virchow Groups | +919394860022 | Telangana, India | 24 | 58 | Inquiry |
| Hitesh Chemicals And Drugs Pvt Ltd | +91-4023352606 +91-4023352643 | Telangana, India | 2 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6157 | 58 | Inquiry |
| Shree Sadguru Enterprise | 08046076695 | Gujarat, India | 126 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| Virchow Groups | 58 |
| Hitesh Chemicals And Drugs Pvt Ltd | 58 |
| OCEAN TRADING CORPORATION | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| Shree Sadguru Enterprise | 58 |