Methimazole
- CAS No.
- 60-56-0
- Chemical Name:
- Methimazole
- Synonyms
- THIAMAZOLE;1-METHYL-1H-IMIDAZOLE-2-THIOL;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;TAPAZOLE;2-MERCAPTO-1-METHYLIMIDAZOLE;Thiamazol;Thimazole;Mercazole;METHIAZOLE;1-Methyl-1H-iMidazole-2(3H)-thione
- CBNumber:
- CB9220870
- Molecular Formula:
- C4H6N2S
- Molecular Weight:
- 114.17
- MOL File:
- 60-56-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/28 15:15:04
| Melting point | 144-147 °C (lit.) |
|---|---|
| Boiling point | 280 °C |
| Density | 1.176 (estimate) |
| refractive index | 1.5000 (estimate) |
| Flash point | 280°C |
| storage temp. | 2-8°C |
| solubility | 200g/l |
| form | Crystalline Powder |
| pka | 12.37±0.50(Predicted) |
| color | White to slightly cream or pale buff |
| Water Solubility | soluble |
| Merck | 14,5971 |
| BRN | 108646 |
| CAS DataBase Reference | 60-56-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Methimazole(60-56-0) |
| IARC | 3 (Vol. 79) 2001 |
| EPA Substance Registry System | Methimazole (60-56-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319-H361fd | |||||||||
| Precautionary statements | P202-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 43-62-63-22 | |||||||||
| Safety Statements | 26-27-36-45-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI8615000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29332990 | |||||||||
| NFPA 704 |
|
Methimazole price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M8506 | Methimazole analytical standard | 60-56-0 | 25G | ₹4178.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3037 | Methimazole pharmaceutical secondary standard, certified reference material | 60-56-0 | 500MG | ₹15490.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M8506 | Methimazole analytical standard | 60-56-0 | 100G | ₹12665.25 | 2022-06-14 | Buy |
| Sigma-Aldrich | 301507 | 2-Mercapto-1-methylimidazole ≥99% | 60-56-0 | 5G | ₹1926.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 301507 | 2-Mercapto-1-methylimidazole ≥99% | 60-56-0 | 5G | ₹1926.85 | 2022-06-14 | Buy |
Methimazole Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid
General Description
Methimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.
Clinical Use
Methimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.
Safety Profile
Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.
Purification Methods
Crystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]
Methimazole Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| Innova Pharmactive Pvt. Ltd | +91-7122649427 +91-7122649427 | Mumbai, India | 9 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| MAITHRI DRUGS PRIVATE LTD | +91 40 30438600 | New Delhi, India | 29 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JIVICHEM SYNTHESIS PVT LTD | 58 |
| Innova Pharmactive Pvt. Ltd | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Maithri Drugs Pvt Ltd | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| MAITHRI DRUGS PRIVATE LTD | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Alfa Aesar | 58 |
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