Isopropyl isocyanate
- CAS No.
- 1795-48-8
- Chemical Name:
- Isopropyl isocyanate
- Synonyms
- 2-Isocyanatopropane;i-pic;Isopropylisocyanat;2-PROPYLISOCYANATE;2-isocyanato-propan;sopropyl isocyanete;Isorpopyl Isocyanate;ISOPROPYL ISOCYANATE;Propane,2-isocyanato-;IsopropylIsocyanate>
- CBNumber:
- CB1249969
- Molecular Formula:
- C4H7NO
- Molecular Weight:
- 85.1
- MOL File:
- 1795-48-8.mol
- Modify Date:
- 2023/8/15 17:37:19
| Melting point | <-75℃ |
|---|---|
| Boiling point | 74-75 °C(lit.) |
| Density | 0.866 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 27 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Ethyl Acetate |
| form | Oil |
| color | Colourless |
| Water Solubility | Insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 969356 |
| Stability | Hygroscopic, Light Sensitive, Moisture Sensitive, Volatile |
| CAS DataBase Reference | 1795-48-8(CAS DataBase Reference) |
| EPA Substance Registry System | Propane, 2-isocyanato- (1795-48-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H315-H317-H319-H330-H334-H335 | |||||||||
| Precautionary statements | P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,T+,Xi | |||||||||
| Risk Statements | 11-26-36/37/38-42 | |||||||||
| Safety Statements | 16-23-26-36/37/39-45 | |||||||||
| RIDADR | UN 2483 3/PG 1 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Y | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29291090 | |||||||||
| NFPA 704 |
|
Isopropyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Uses
Isopropyl isocyanate is used as a reagent in the preparation of androgen receptor antagonist for prostate cancer treatment. It is also used in the synthesis of selective dual inhibitor of mammalian target of rapamycin (mTORC1 and mTORC2). Further, it serves as a reagent in the synthesis of O-aryl N-isopropylcarbamates. In addition to this, it is used as a derivatization reagent during the stereoisomeric analysis of secondary alcohols.
General Description
A colorless liquid with a pungent odor. Insoluble in water. Flash point near 60°F. Very toxic by ingestion and inhalation. Vapors are heavier than air. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Isocyanates and thioisocyanates, such as Isopropyl isocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Isopropyl isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Paushak Limited | +91-2653007932 +91-9727736899 | Vadodara, India | 59 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Paushak Limited | +91 (265) 228-0724 | New Delhi, India | 20 | 50 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12452 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16920 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29896 | 58 | Inquiry |