Isopropyl myristate
- CAS No.
- 110-27-0
- Chemical Name:
- Isopropyl myristate
- Synonyms
- IPM;1-Methylethyl tetradecanoate;MYRISTIC ACID ISOPROPYL ESTER;IPM 100;BISOMEL;Propyl myristate;sopropyl myristate;ISOPROPYL TETRADECANOATE;ISO-PROPYL N-TETRADECANOATE;MYRISTIC ACID ISOPROPYL ESTER MINIMU
- CBNumber:
- CB9482638
- Molecular Formula:
- C17H34O2
- Molecular Weight:
- 270.45
- MOL File:
- 110-27-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/8 13:40:43
| Melting point | ~3 °C (lit.) |
|---|---|
| Boiling point | 193 °C/20 mmHg (lit.) |
| Density | 0.85 g/mL at 25 °C (lit.) |
| vapor pressure | <1 hPa (20 °C) |
| FEMA | 3556 | ISOPROPYL MYRISTATE |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | <0.05mg/l |
| form | Liquid |
| color | Clear |
| Specific Gravity | 0.855 (20/4℃) |
| Odor | odorless |
| Water Solubility | Miscible with alcohol. Immiscible with water and glycerol. |
| Merck | 14,5215 |
| JECFA Number | 311 |
| BRN | 1781127 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | AXISYYRBXTVTFY-UHFFFAOYSA-N |
| LogP | 7.71 |
| CAS DataBase Reference | 110-27-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Isopropyl Myristate(110-27-0) |
| EPA Substance Registry System | Isopropyl myristate (110-27-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315 | |||||||||
| Precautionary statements | P264-P280g-P302+P352a-P321-P332+P313-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | XB8600000 | |||||||||
| Autoignition Temperature | >300 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29159080 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Isopropyl myristate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W355690 | Isopropyl myristate ≥98% | 110-27-0 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W355690 | Isopropyl myristate ≥98% | 110-27-0 | 1KG | ₹11907.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W355690 | Isopropyl myristate ≥98% | 110-27-0 | 8KG | ₹31349.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W355690 | Isopropyl myristate ≥98% | 110-27-0 | 20KG | ₹63196.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1123 | Isopropyl myristate Pharmaceutical Secondary Standard; Certified Reference Material | 110-27-0 | 1G | ₹8270.3 | 2022-06-14 | Buy |
Isopropyl myristate Chemical Properties,Uses,Production
Description
Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.
Chemical Properties
Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.
Occurrence
Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat
Uses
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .
Preparation
By conventional esterification of isopropanol with myristic acid
Production Methods
Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.
General Description
Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Isopropyl myristate is a nongreasy emollient that is absorbed readily
by the skin. It is used as a component of semisolid bases and as a
solvent for many substances applied topically. Applications in
topical pharmaceutical and cosmetic formulations include bath oils;
make-up; hair and nail care products; creams; lotions; lip products;
shaving products; skin lubricants; deodorants; otic suspensions; and
vaginal creams. For example, isopropyl myristate is a
self-emulsifying component of a proposed cold cream formula,
which is suitable for use as a vehicle for drugs or dermatological
actives; it is also used cosmetically in stable mixtures of water and
glycerol.
Isopropyl myristate is used as a penetration enhancer for
transdermal formulations, and has been used in conjunction with
therapeutic ultrasound and iontophoresis.It has been used in a
water-oil gel prolonged-release emulsion and in various microemulsions.
Such microemulsions may increase bioavailability in topical
and transdermal applications. Isopropyl myristate has also been
used in microspheres, and significantly increased the release of drug
from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive
adhesive tapes.
Contact allergens
Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.
Side effects
Thrapecylate myristate is a medicine used to treat head lice infestations in adults and children 4 years of age and older. Common side effects include skin irritation, rash, and contact dermatitis.
Safety
Isopropyl myristate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg
Synthesis
Isopropyl myristate is synthesized by conventional esterification of iso-Propanol with Myristic acid.
Metabolism
Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,
storage
Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.
Incompatibilities
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.
Regulatory Status
Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Isopropyl myristate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HJ AROCHEM | +91-8690768060 +91-9724420086 | Ahmedabad, India | 171 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Agilenobel | +91-8090295395 +91-8800293647 | Haryana, India | 50 | 58 | Inquiry |
| Soujanya Life Sciences | +91-9717304919 +91-9717304919 | Mumbai, India | 17 | 58 | Inquiry |
| Triveni Interchem Private Limited | +91-02606618618 +91-7574814001 | Gujarat, India | 42 | 58 | Inquiry |
| Dadia Chemical Industries | +91-9920521550 +91-9892510297 | Maharashtra, India | 18 | 58 | Inquiry |
| Godrej Industries Ltd | +919820305315 | Maharashtra, India | 41 | 58 | Inquiry |
| Dadia Chemical Industries | 08047631996 | Mumbai, India | 22 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| HJ AROCHEM | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| JSK Chemicals | 58 |
| Agilenobel | 58 |
| Soujanya Life Sciences | 58 |
| Triveni Interchem Private Limited | 58 |
| Dadia Chemical Industries | 58 |
| Godrej Industries Ltd | 58 |
| Dadia Chemical Industries | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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