Myristic acid
- CAS No.
- 544-63-8
- Chemical Name:
- Myristic acid
- Synonyms
- TETRADECANOIC ACID;C14:0;MYRISTATE acid;NAA104;Crodacid;Myristinsαure;n-Tetradecan-1-oic acid;14:0;NAA142;NSC 5028
- CBNumber:
- CB1104862
- Molecular Formula:
- C14H28O2
- Molecular Weight:
- 228.37
- MOL File:
- 544-63-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 52-54 °C(lit.) |
|---|---|
| Boiling point | 250 °C100 mm Hg(lit.) |
| Density | 0.862 |
| vapor pressure | <0.01 hPa (20 °C) |
| FEMA | 2764 | MYRISTIC ACID |
| refractive index | nD60 1.4305; nD70 1.4273 |
| Flash point | >230 °F |
| storage temp. | room temp |
| solubility | 1.07mg/l |
| pka | 4.78±0.10(Predicted) |
| form | Flakes, Powder, Chunks or Crystalline Mass |
| color | White |
| Odor | at 100.00 %. waxy fatty soapy coconut |
| Odor Type | waxy |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| Merck | 14,6333 |
| JECFA Number | 113 |
| BRN | 508624 |
| Stability | Stable. Incompatible with strong oxidizing agents, bases. |
| LogP | 5.79 |
| CAS DataBase Reference | 544-63-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Tetradecanoic acid(544-63-8) |
| EPA Substance Registry System | Myristic acid (544-63-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | QH4375000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29159080 | |||||||||
| Toxicity | LD50 i.v. in mice: 432.6 mg/kg (Or, Wretlind) | |||||||||
| NFPA 704 |
|
Myristic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W276413 | Myristic acid natural, ≥98.5%, FG | 544-63-8 | 1SAMPLE-K | ₹5347.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W276413 | Myristic acid natural, ≥98.5%, FG | 544-63-8 | 1KG | ₹8497.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W276413 | Myristic acid natural, ≥98.5%, FG | 544-63-8 | 10KG | ₹41416.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W276413 | Myristic acid natural, ≥98.5%, FG | 544-63-8 | 25KG | ₹68847 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W276405 | Myristic acid ≥95%, FCC, FG | 544-63-8 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
Myristic acid Chemical Properties,Uses,Production
Description
Myristic acid, also called tetradecanoic acid , is a common saturated fatty acid with the molecular formula CH3(CH2)12COOH. A myristate is a salt or ester of myristic acid.
Myristic acid is named after the nutmeg Myristica fragrans. Nutmeg butter is 75 % trimyristin, the triglyceride of myristic acid. Besides nutmeg, myristic acid is also found in palm kernel oil, coconut oil, butter fat and is a minor component of many other animal fats. It is also found in spermaceti, the crystallized fraction of oil from the sperm whale.
Myristic acid is also commonly added co-translationally to the penultimate, nitrogen-terminus, glycine in receptor-associated kinases to confer the membrane localisation of the enzyme. The myristic acid has a sufficiently high hydrophobicity to become incorporated into the fatty acyl core of the phospholipid bilayer of the plasma membrane of the eukaryotic cell. In this way, myristic acid acts as a lipid anchor in biomembranes.
The ester isopropyl myristate is used in cosmetic and topical medicinal preparations where good absorption through the skin is desired.
Reduction of myristic acid yields myristyl aldehyde and myristyl alcohol.
Chemical Properties
Myristic acid occurs as an oily white crystalline solid with a faint odor.
Occurrence
Reported found in nutmeg, palm seed, sperm whale oil, blue cheese, burley tobacco, cooked beef and chicken, fish, rum, apricot, banana, lemon and grapefruit juice, cranberry, guava, grapes, melon, papaya, raspberry, strawberry fruit and jam, cucumber, tomato, many cheeses, thyme, breads, butter, milk, lamb liver, pork, hop oil, beer, cognac, whiskies, peanut oil, cocoa, tea, coconut meat and milk, cloudberry, beans, passion fruit, mushroom, mango, starfruit, tamarind, kelp, cardamom, rice, buckwheat, watercress, malt, wort, loquat, Bourbon vanilla, lemon balm, shrimp, nectarine, crab, scallop, squid, cape gooseberry, Chinese quince, pawpaw and sweet grass oi
Uses
Myristic Acid is a common saturated fatty acid found in nutmeg, palm kernel oil, coconut oil and butter fat.
Preparation
From fatty acid mixture of palm seed oil
Production Methods
Myristic acid occurs naturally in nutmeg butter and in most animal and vegetables fats. Synthetically, it may be prepared by electrolysis of methyl hydrogen adipate and decanoic acid or by Maurer oxidation of myristyl alcohol.
Definition
ChEBI: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.
General Description
Oily white crystalline solid.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Myristic acid is probably combustible.
Pharmaceutical Applications
Myristic acid is used in oral and topical pharmaceutical formulations. Myristic acid has been evaluated as a penetration enhancer in melatonin transdermal patches in rats and bupropion formulations on human cadaver skin.Further studies have assessed the suitability of myristic acid in oxymorphone formulations and clobetasol 17-propionate topical applications.Furthermore, polyvinyl alcohol substituted with myristic acid (as well as other fatty acids) at different substitution degrees has been used for the preparation of biodegradable microspheres containing progesterone or indomethacin.
Safety Profile
Poison by intravenous route. Mutation data reported. An eye and human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Myristic acid is used in oral and topical pharmaceutical formulations
and is generally regarded as nontoxic and nonirritant at the
levels employed as an excipient. However, myristic acid is reported
to be an eye and skin irritant at high levels and is poisonous by
intravenous administration. Mutation data have also been
reported.
LD50 (mouse, IV): 0.043 g/kg
LD50 (rat, oral): >10 g/kg
storage
The bulk material should be stored in a well-closed container in a cool, dry, place.
Purification Methods
Purify the acid via the methyl ester (b 153-154o/10mm, n25 1.4350), as for capric acid. [Trachtman & Miller J Am Chem Soc 84 4828 1962.] Also purify it by zone melting. It crystallises from pet ether, and is dried in a vacuum desiccator containing shredded wax. [Beilstein 2 IV 1126.]
Incompatibilities
Myristic acid is incompatible with strong oxidizing agents and bases.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules). Included in nonparenteral medicines licensed in the UK.
Myristic acid Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Agilenobel | +91-8090295395 +91-8800293647 | Haryana, India | 50 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Vinayak Enterprise | 07942533713 | Gujarat, India | 9 | 58 | Inquiry |
| Satyam Enterprises | 08046045554 | Delhi, India | 17 | 58 | Inquiry |
| Camex Speciality Private Limited | 08046051668 | Ahmedabad, India | 117 | 58 | Inquiry |
| Shree Radhey Enterprises | 08046043707 | Delhi, India | 21 | 58 | Inquiry |
| Satyam Biotech | 07942566165 | Delhi, India | 11 | 58 | Inquiry |
| RX Pharmachem | 07942564226 | Ahmedabad, India | 8 | 58 | Inquiry |
| Atlas Chemicals | 08046053916 | Pune, India | 20 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Agilenobel | 58 |
| CHEMSWORTH | 30 |
| Vinayak Enterprise | 58 |
| Satyam Enterprises | 58 |
| Camex Speciality Private Limited | 58 |
| Shree Radhey Enterprises | 58 |
| Satyam Biotech | 58 |
| RX Pharmachem | 58 |
| Atlas Chemicals | 58 |
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