미리스틸산이소프로필에스테르
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미리스틸산이소프로필에스테르 속성
- 녹는점
- ~3 °C (lit.)
- 끓는 점
- 193 °C/20 mmHg (lit.)
- 밀도
- 0.85 g/mL at 25 °C (lit.)
- 증기압
- <1 hPa (20 °C)
- 굴절률
- n
20/D 1.434(lit.)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- <0.05mg/L
- 물리적 상태
- 액체
- 색상
- 투명한
- Specific Gravity
- 0.855 (20/4℃)
- 냄새
- 냄새 없는
- 수용성
- 알코올과 섞임. 물과 글리세롤과 혼합되지 않습니다.
- Merck
- 14,5215
- JECFA Number
- 311
- BRN
- 1781127
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- AXISYYRBXTVTFY-UHFFFAOYSA-N
- LogP
- 7.71
- CAS 데이터베이스
- 110-27-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | - | ||
RTECS 번호 | XB8600000 | ||
자연 발화 온도 | >300 °C | ||
TSCA | Yes | ||
HS 번호 | 29159080 | ||
유해 물질 데이터 | 110-27-0(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | ||
기존화학 물질 | KE-33355 |
미리스틸산이소프로필에스테르 C화학적 특성, 용도, 생산
개요
Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.화학적 성질
Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.출처
Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat용도
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .제조 방법
By conventional esterification of isopropanol with myristic acid생산 방법
Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.일반 설명
Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.
색상 색인 번호
Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.부작용
Thrapecylate myristate is a medicine used to treat head lice infestations in adults and children 4 years of age and older. Common side effects include skin irritation, rash, and contact dermatitis.Safety
Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg
Synthesis
Isopropyl myristate is synthesized by conventional esterification of iso-Propanol with Myristic acid.신진 대사
Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,저장
Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.비 호환성
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.Regulatory Status
Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.미리스틸산이소프로필에스테르 준비 용품 및 원자재
원자재
준비 용품
미리스틸산이소프로필에스테르 공급 업체
글로벌( 759)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
Yancheng Green Chemicals Co.,Ltd | +undefined-86-25-86655873 |
info@royal-chem.com | China | 114 | 58 |
Gansu Jinyuantai New Material Co., Ltd. | +86-025-86618065 +86-13914714331 |
sales@jinyuantaichem.com | China | 73 | 58 |
Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 |
info@nxjhchem.com | China | 79 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 988 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |