Isopropyl palmitate
- CAS No.
- 142-91-6
- Chemical Name:
- Isopropyl palmitate
- Synonyms
- ISOPROPYL HEXADECANOATE;Deltyl;plymouthipp;ISOPROPYLPALMITAT;kesscoisopropylpalmitate;Isopal;Isopalm;Emcol-IP;estol103;ja-faipp
- CBNumber:
- CB0451826
- Molecular Formula:
- C19H38O2
- Molecular Weight:
- 298.5
- MOL File:
- 142-91-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 11-13 °C (lit.) |
|---|---|
| Boiling point | 160°C 2mm |
| Density | 0.852 g/mL at 25 °C (lit.) |
| vapor pressure | 0.007Pa at 25℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | <0.001g/l |
| form | <11°C Solid,>13°C Liquid |
| color | Colourless |
| Odor | very sl. odor |
| biological source | synthetic |
| Water Solubility | Not miscible or difficult to mix with water. |
| BRN | 1786567 |
| InChIKey | XUGNVMKQXJXZCD-UHFFFAOYSA-N |
| LogP | 8.16 |
| CAS DataBase Reference | 142-91-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Isopropyl palmitate(142-91-6) |
| EPA Substance Registry System | Isopropyl palmitate (142-91-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | RT4900000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29157090 | |||||||||
| Hazardous Substances Data | 142-91-6(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689, | |||||||||
| NFPA 704 |
|
Isopropyl palmitate price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W515604 | Isopropyl palmitate ≥90% | 142-91-6 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W515604 | Isopropyl palmitate ≥90% | 142-91-6 | 1KG | ₹7436.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W515604 | Isopropyl palmitate ≥90% | 142-91-6 | 9KG | ₹32399.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 291781 | Isopropyl palmitate technical grade, 90% | 142-91-6 | 1L | ₹3258.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1137 | Isopropyl palmitate Pharmaceutical Secondary Standard; Certified Reference Material | 142-91-6 | 1G | ₹8270.3 | 2022-06-14 | Buy |
Isopropyl palmitate Chemical Properties,Uses,Production
Chemical Properties
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C.
Uses
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.
Production Methods
Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.
Definition
ChEBI: Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a fatty acid ester and an isopropyl ester. It is functionally related to a hexadecanoic acid.
General Description
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate
Side effects
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.
Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided.
Safety
Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
storage
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16°C, and protected from light.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical and transdermal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Isopropyl palmitate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Agilenobel | +91-8090295395 +91-8800293647 | Haryana, India | 50 | 58 | Inquiry |
| Godrej Industries Ltd | +919820305315 | Maharashtra, India | 41 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4315 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6157 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3075 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Murli Krishna Exports Pvt Ltd | 58 |
| Agilenobel | 58 |
| Godrej Industries Ltd | 58 |
| JSK Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
Related articles
- Synthesis of Isopropyl palmitate
- Isopropyl palmitate is prepared by a two step lipase catalysed hydrolysis reaction with palm stearin as the raw material.
- Dec 25，2023
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