L-Histidine
- CAS No.
- 71-00-1
- Chemical Name:
- L-Histidine
- Synonyms
- HISTIDINE;HIS;H-HIS-OH;L-HIS;L-HISTIDINE BASE;L-His-OH;L-Histidin;(S)-2-aMino-3-(1H-iMidazol-4-yl)propanoic acid;Histidin;L-Hisidine
- CBNumber:
- CB6705020
- Molecular Formula:
- C6H9N3O2
- Molecular Weight:
- 155.15
- MOL File:
- 71-00-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/29 13:04:38
| Melting point | 282 °C (dec.)(lit.) |
|---|---|
| alpha | 12.4 º (c=11,6N HCl) |
| Boiling point | 278.95°C (rough estimate) |
| Density | 1.3092 (rough estimate) |
| FEMA | 3694 | L-HISTIDINE |
| refractive index | 13 ° (C=11, 6mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 1.8(at 25℃) |
| color | White to off-white or pale yellow |
| PH | 7.0-8.0 (25℃, 0.1M in H2O) |
| PH Range | 7 - 8 at 15.5 g/l at 25 °C |
| Odor | odorless |
| Odor Type | odorless |
| optical activity | [α]20/D 39±1°, c = 2% in H2O |
| Water Solubility | 41.6 g/L (25 ºC) |
| λmax |
λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 |
| JECFA Number | 1431 |
| Merck | 14,4720 |
| BRN | 4673585 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | HNDVDQJCIGZPNO-YFKPBYRVSA-N |
| LogP | -1.27 |
| CAS DataBase Reference | 71-00-1(CAS DataBase Reference) |
| NIST Chemistry Reference | L-Histidine(71-00-1) |
| EPA Substance Registry System | L-Histidine (71-00-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 24/25-36/37-26-22 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MS3070000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29332990 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5110 mg/kg | |||||||||
| NFPA 704 |
|
L-Histidine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H8000 | L-Histidine ReagentPlus?, ≥99% (TLC) | 71-00-1 | 10G | ₹1820 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8000 | L-Histidine ReagentPlus?, ≥99% (TLC) | 71-00-1 | 5G | ₹1940 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8000 | L-Histidine ReagentPlus?, ≥99% (TLC) | 71-00-1 | 25G | ₹2150 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8000 | L-Histidine ReagentPlus?, ≥99% (TLC) | 71-00-1 | 100G | ₹5900 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8000 | L-Histidine ReagentPlus?, ≥99% (TLC) | 71-00-1 | 500G | ₹25287.2 | 2022-06-14 | Buy |
L-Histidine Chemical Properties,Uses,Production
Description
White, odorless crystals or crystalline powder having a slightly bitter taste. It is soluble in water, very slightly soluble in alcohol, and insoluble in ether. It melts with decomposition between about 277° and 288°C.
Chemical Properties
L-Histidine is an odorless powder with slightly bitter taste
Occurrence
Reported found in water bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley, brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, Parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, almonds, cashews, peanuts, dates, beef, lamb, veal, chicken, turkey and other natural sources
Uses
L-Histidine is an essential amino acid for human development which the body cannot produce on its own. L-Histidine is one of the 22 proteinogenic amino acids. L-Histidine precursor to histamine (H4365 00) and a component of carnosine.
Definition
ChEBI: The L-enantiomer of the amino acid histidine.
Purification Methods
A likely impurity is arginine. S-Histidine is adsorbed from aqueous solution onto a Dowex 50-H+ ion-exchange resin, washed with 1.5M HCl (to remove other amino acids), then eluted with 4M HCl as the dihydrochloride. This purified dihydrochloride (see below) is finally dissolved in water, the pH adjusted to 7.0, and the free zwitterionic base crystallises out on addition of EtOH. Its solubility in H2O is 4.2% at 25o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1971-1993 1961, Beilstein 25 III/IV 4344.]
L-Histidine Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNOVA CHEMICALS | 58 |
| AMINO ORGANICS | 58 |
| JSK Chemicals | 58 |
| Meteoric Biopharmaceuticals Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| Maas Pharma Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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