L-Carnosine

L-Carnosine Properties

Melting point	253 °C (dec.) (lit.)
Boiling point	367.84°C (rough estimate)
alpha	20.9 º (c=1.5, H2O)
Density	1.2673 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	21 ° (C=2, H2O)
storage temp.	-20°C
solubility	DMSO (Very Slightly), Water (Slightly)
form	crystalline
pka	2.62(at 25℃)
color	White
Odor	at 100.00?%. odorless
Water Solubility	almost transparency
Merck	14,1850
BRN	87671
Stability	Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents.
InChIKey	CQOVPNPJLQNMDC-ZETCQYMHSA-N
LogP	-3.8 at 22℃
CAS DataBase Reference	305-84-0(CAS DataBase Reference)
EPA Substance Registry System	L-Histidine, .beta.-alanyl- (305-84-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	24/25-36-26
WGK Germany	2
RTECS	MS3080000
F	3-10
TSCA	Yes
HS Code	29332900
Toxicity	LD50 oral in mouse: > 14930mg/kg

L-Carnosine price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C9625	L-Carnosine ~99%, crystalline	305-84-0	10MG	₹2121.7	2022-06-14	Buy
Sigma-Aldrich(India)	C9625	L-Carnosine ~99%, crystalline	305-84-0	5G	₹10640.98	2022-06-14	Buy
Sigma-Aldrich(India)	C9625	L-Carnosine ~99%, crystalline	305-84-0	25G	₹27149.1	2022-06-14	Buy
Sigma-Aldrich(India)	C9625	L-Carnosine ~99%, crystalline	305-84-0	100G	₹94329.05	2022-06-14	Buy
TCI Chemicals (India)	A0222	β-Alanyl-L-histidine	305-84-0	1G	₹2400	2022-05-26	Buy

Product number	Packaging	Price	Buy
C9625	10MG	₹2121.7	Buy
C9625	5G	₹10640.98	Buy
C9625	25G	₹27149.1	Buy
C9625	100G	₹94329.05	Buy
A0222	1G	₹2400	Buy

L-Carnosine Chemical Properties,Uses,Production

Description

L-Carnosine is a dipeptide composed of β-alanine and L-histidine that has been found in rat olfactory bulb, skeletal muscle, brain, kidney, and spleen tissues, as well as human skeletal muscle, and has diverse biological activities. It is a metal chelator that forms complexes with copper, cobalt, nickel, cadmium, or zinc. Dietary administration of L-carnosine (60 mg/kg per day) reduces plasma levels of advanced glycation end products (AGEs) in diabetic rats. It reduces brain edema, blood-brain barrier disruption, microglial activation, and neuronal apoptosis in a rat model of intracerebral hemorrhage when administered at a dose of 1,000 mg/kg. L-Carnosine (250, 500, and 1,000 mg/kg, i.p.) reduces hepatic protein carbonylation and necrosis in a rat model of cirrhosis induced by bile duct ligation. It also reduces lung myeloperoxidase (MPO) activity, production of reactive oxygen species (ROS), and TNF-α and IL-6 levels, as well as alveolar hemorrhage, interstitial edema, and pulmonary leukocyte infiltration in a mouse model of LPS-induced lung injury.

Chemical Properties

white to off-white crystalline.

History

Carnosine, a dipeptide composed of beta-alanine and L-histidine, was first identified in beef extracts by Russian chemists Gulewitch and Amiradzibi in 1900.

Uses

L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include action s as neurotransmitters, modulation of enzymic activities and chelation of heavy metals. Studies indicate an ability to boost the immunological functions. In cosmetics, it has anti-aging and skin-conditioning applications.

Definition

ChEBI: Carnosine is a dipeptide that is the N-(beta-alanyl) derivative of L-histidine. It has a role as an anticonvulsant, an antioxidant, an antineoplastic agent, a human metabolite, a Daphnia magna metabolite, a mouse metabolite, a neuroprotective agent and a geroprotector. It is a conjugate acid of a carnosinate. It is a tautomer of a carnosine zwitterion.

Side effects

L-carnosine is generally considered safe when taken by mouth for short periods of time or when used by adults on the skin. However, there can be rare side effects, including rash, itchiness, dry mouth, changes in appetite, feelings of tiredness or vivid dreams. Rare but severe possible zinc carnosine side effects include decreased white blood cells, disorder of the digestive system and sideroblastic anemia. Less severe side effects may include stomach cramps, indigestion and nausea.

Safety Profile

Mildly toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Likely impurities are histidine and β-alanine. Crystallise L-carnosine from water by adding EtOH in excess. Recrystallise it from aqueous EtOH by slow addition of EtOH to a strong aqueous solution of the dipeptide. Its solubility in H2O is 33.3% at 25o. [Vinick & Jung J Org Chem 48 392 1983, Turner J Am Chem Soc 75 2388 1953, Sifford & du Vigneaud J Biol Chem 108 753 1935, Beilstein 25 H 516, 25 I 717, 25 II 408.]

References

1. P. J. Quinn, A. A. Boldyrev, V. E. Formazuyk, Carnosine: Its properties, functions and potential therapeutic applications, Molecular Aspects of Medicine, 1992, vol. 13, pp. 379-444 DOI:10.1016/0098-2997(92)90006-L
2. https://www.webmd.com/vitamins/ai/ingredientmono-1038/carnosine
3. G. M. Halpern, Zinc-Carnosine: Nature’s Safe and Effective Remedy for Ulcers, 2005, ISBN-10 0757002749
4. l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism DOI:10.2337/db07-0177
5. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. DOI:10.1042/BJ3040509
6. Boldyrev, A.A., Aldini, G., and Derave, W. Physiology and pathophysiology of carnosine. Physiol. Rev. 93(4), 1803-1845 (2013). DOI:10.1152/physrev.00039.2012
7. Ghodsi, R., and Kheirouri, S. Carnosine and advanced glycation end products: A systematic review. Amino Acids 50(9), 1177-1186 (2018). DOI:10.1007/s00726-018-2592-9
8. Tanaka, K.I., Sugizaki, T., Kanada, Y., et al. Preventive effects of carnosine on lipopolysaccharide-induced lung injury. Sci. Rep. 7:42813, (2017). DOI:10.1038/srep42813

L-Carnosine Preparation Products And Raw materials

Raw materials

D-Histidine tert-Butyl cyanoacetate

Preparation Products

L-Carnosine Suppliers

Global( 762)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
RIDDHI PHARMA	+91 7874046933	Gujarat, India	43	58	Inquiry
Bulat Pharmaceutical Pvt Ltd	+91-8448085659 +91-8448085660	Haryana, India	123	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Panvo Organics Pvt Ltd	+91 9789806833 +91 9444351711	Tamil Nadu, India	23	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry

Supplier	Advantage
RIDDHI PHARMA	58
Bulat Pharmaceutical Pvt Ltd	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Panvo Organics Pvt Ltd	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Maas Pharma Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Otto Chemie Pvt. Ltd.	58
Alfa Aesar	58

L-Carnosine Spectrum

L-Carnosine(305-84-0)MS L-Carnosine(305-84-0)¹HNMR L-Carnosine(305-84-0)IR1 L-Carnosine(305-84-0)IR2 L-Carnosine(305-84-0)Raman

305-84-0(L-Carnosine)Related Search:

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n-acetyl carnosine,N-ACETYL-L-CARNOSINE,N-Aceyl-L-Carnosine L-ANSERINE NITRATE ZINC CARNOSINE,zinc l-carnosine complex,Zinc L-Carnosine,Zn Carnosine,carnosine, zinc- Carnosine

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L-Histidine,beta-alanyl- L-Carnosine (beta-Alanyl-L-histidine) β-Ala-His-OH L-Carnosine,N-beta-Alanyl-L-histidine H-BETA-ALA-HIS-OH L-IGNOTINE L-BETA-ALANINE HISTIDINE L-CARNOSINE B-ALANYL-L-HISTIDINE BETA-A-H BETA-ALA-L-HIS BETA-ALA-HIS CARNOSINE, L- Beta-Alanyl-L-Hystidine L-CARNOSINE CRYSTALLINE L-Carnosine(H-b-Ala-His-Oh) N-β-Alanyl-L-histidine (2S)-2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid L-HISTIDINE,N-BETA-ALANYL H-SS-ALA-HIS-OH (L-CARNOSINE) L-B-ALANINE HISTIDINE L-CARNITINEOROTIC H-SS-ALA-HIS-OH H-b-Ala-His-OH Karnozin β-Ala-L-His-OH L-Carnosine,98% L-Carnosine L-Ignotine H-Beta-Ala-His-OH(L-Carnosine) beta-Alanyl-histidine ignotine karnozzn n-2-m Nalpha-(beta-alanyl)-L-histidine n-beta-alanyl-l-histidin L-Carnosine Vetec(TM) reagent grade, 98% Polaprezinc Impurity 6 (2S)-2-(3-Aminopropanamido)-3-(4H-imidazol-4-yl)propanoicacid Carnosin、L-Carnosine L-Carnosine / Carnosine L-Carnosine Reference Material beta L β-Alanyl-L-histidine> 2,5-diamino-3-(1H-imidazol-5-yl)-4-oxohexanoic acid L-Histidine, β-alanyl- L-Carnosine USP/EP/BP carnosine/l-carnosine (2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid N-B-ALANYL-L-HISTIDINE BETA-ALANYL-L-HISTIDINE CARNOSINE N-BETA-ALANYL-L-HISTIDINE Carnosin Dragosine H-β-Ala-His-OH β-Ala-His β-Alanyl-L-histidine β-Alanyl-L-histidine