L-Glutamine
- CAS No.
- 56-85-9
- Chemical Name:
- L-Glutamine
- Synonyms
- GLUTAMINE;GLN;H-GLN-OH;L-GLN;L-Glutamin;L-Gln-OH;L-GLUTAMIC ACID AMIDE;Concentrated Soy Protein;(S)-2,5-DIAMINO-5-OXOPENTANOIC ACID;L-GUTAMINE
- CBNumber:
- CB6280105
- Molecular Formula:
- C5H10N2O3
- Molecular Weight:
- 146.14
- MOL File:
- 56-85-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/21 19:06:49
| Melting point | 185 °C (dec.) (lit.) |
|---|---|
| Boiling point | 265.74°C (rough estimate) |
| alpha | 32.25 º (c=10, 2 N HCl) |
| Density | 1.47 g/cm3 (20℃) |
| bulk density | 640kg/m3 |
| FEMA | 3684 | L-GLUTAMINE |
| refractive index | 6.8 ° (C=4, H2O) |
| Flash point | 185°C |
| storage temp. | Store below +30°C. |
| solubility | H2O: 25 mg/mL |
| form | solution |
| pka | 2.17(at 25℃) |
| color | White |
| PH | 5.0-6.0 (25℃, 0.1M in H2O) |
| Odor | at 100.00 %. very mild milky custard cocoa oily |
| Odor Type | milky |
| biological source | synthetic |
| optical activity | [α]20/D +33.0±1°, c = 5% in 5 M HCl |
| Water Solubility | Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform. |
| Decomposition | 185 ºC |
| λmax |
λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 |
| JECFA Number | 1430 |
| Merck | 14,4471 |
| BRN | 1723797 |
| Stability | Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents. |
| InChIKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| LogP | -1.67 |
| CAS DataBase Reference | 56-85-9(CAS DataBase Reference) |
| NIST Chemistry Reference | L-Glutamine(56-85-9) |
| EPA Substance Registry System | L-Glutamine (56-85-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 26-24/25-36/37/39-27 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MA2275100 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29241900 | |||||||||
| Hazardous Substances Data | 56-85-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 7500 mg/kg | |||||||||
| NFPA 704 |
|
L-Glutamine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W368401 | L-Glutamine | 56-85-9 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G8540 | L-Glutamine meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source | 56-85-9 | 10MG | ₹3171.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W368401 | L-Glutamine | 56-85-9 | 1KG | ₹33557.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G8540 | L-Glutamine meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source | 56-85-9 | 25G | ₹4370 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G8540 | L-Glutamine meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source | 56-85-9 | 100G | ₹14580 | 2022-06-14 | Buy |
L-Glutamine Chemical Properties,Uses,Production
Description
Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .
Chemical Properties
L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.
Occurrence
Occurrences in nature
Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.
Uses
L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
Preparation
By isolation from sugar beet juice.
Definition
ChEBI: An optically active form of glutamine having L-configuration.
Biological Functions
Glutamine plays a role in a variety of biochemical functions, including :
Protein synthesis, as any other of the 20 proteinogenic amino acids
Regulation of acid-base balance in the kidney by producing ammonium
Cellular energy, as a source, next to glucose
Nitrogen donation for many anabolic processes, including the synthesis of purines
Carbon donation , as a source , refilling the citric acid cycle
Nontoxic transporter of ammonia in the blood circulation.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.
Safety Profile
Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]
L-Glutamine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 273 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1679 | 43 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1994 | 38 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| SD FINE CHEM LTD | 91-22-24959898/99 | New Delhi, India | 41 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| AMINO ORGANICS | 58 |
| JSK Chemicals | 58 |
| HRV Global Life Sciences | 58 |
| Meteoric Biopharmaceuticals Pvt. Ltd. | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Nuray Chemicals Pvt Ltd | 58 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| CHEMSWORTH | 30 |
| SD FINE CHEM LTD | 58 |
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