L-Tyrosine
- CAS No.
- 60-18-4
- Chemical Name:
- L-Tyrosine
- Synonyms
- TYROSINE;TYR;H-TYR-OH;L-TYR;Tyrosin;L-Tyr-OH;l-tyrosin;L-(-)-TYROSINE;(S)-2-aMino-3-(4-hydroxyphenyl)propanoic acid;L-Tryosine
- CBNumber:
- CB1269334
- Molecular Formula:
- C9H11NO3
- Molecular Weight:
- 181.19
- MOL File:
- 60-18-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | >300 °C (dec.) (lit.) |
|---|---|
| Boiling point | 314.29°C (rough estimate) |
| alpha | -11.65 º (c=5,DIL HCL/H2O 50/50) |
| Density | 1.34 |
| FEMA | 3736 | L-TYROSINE |
| refractive index | -12 ° (C=5, 1mol/L HCl) |
| Flash point | 176 °C |
| storage temp. | Store below +30°C. |
| solubility | 1 M HCl: 25 mg/mL |
| form | powder |
| pka | 2.2(at 25℃) |
| color | White to Pale-brown |
| PH | 6.5 (0.1g/l, H2O) |
| Odor | odorless |
| Odor Type | odorless |
| optical activity | [α]20/D 11.5±1.0°, c = 4% in 1 M HCl |
| Water Solubility | 0.45 g/L (25 ºC) |
| JECFA Number | 1434 |
| Merck | 14,9839 |
| BRN | 392441 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong reducing agents. |
| InChIKey | OUYCCCASQSFEME-QMMMGPOBSA-N |
| LogP | 0.38 |
| CAS DataBase Reference | 60-18-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Tyrosine(60-18-4) |
| EPA Substance Registry System | L-Tyrosine (60-18-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-36-37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YP2275600 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225000 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5110 mg/kg | |||||||||
| NFPA 704 |
|
L-Tyrosine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W373605 | L-Tyrosine FG | 60-18-4 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W373605 | L-Tyrosine FG | 60-18-4 | 100G | ₹6895.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W373605 | L-Tyrosine FG | 60-18-4 | 1KG | ₹17514.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8566 | L-Tyrosine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0% | 60-18-4 | 10MG | ₹2749.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8566 | L-Tyrosine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0% | 60-18-4 | 25G | ₹4243.4 | 2022-06-14 | Buy |
L-Tyrosine Chemical Properties,Uses,Production
Chemical Properties
L-Tyrosine is odorless and has a bland taste. L-Tyrosine is a nonessential amino acid, as it is synthesized in the human body from phenylalanine. It is a precursor to epinephrine, norepinephrine and dopamine, three important neurotransmitters.
Occurrence
Reported found in white bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, almonds, cashews, peanuts, dates, beef, lamb, veal, chicken and turkey.
Uses
L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
Definition
ChEBI: An optically active form of tyrosine having L-configuration.
Safety Profile
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Likely impurities are L-cysteine and the ammonium salt. L-Tyrosine is dissolved in dilute ammonia, then crystallised by adding dilute acetic acid to pH 5. Also, crystallise it from H2O or EtOH/H2O, and dry it at room temperature in a vacuum over P2O5. It sublimes at 235-240o/0.03mm with 99.2% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Albert Biochem J 50 690 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2348-2366 1961, Beilstein 14 IV 2264.]
L-Tyrosine Preparation Products And Raw materials
Raw materials
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