ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >3,5-Diiodo-L-tyrosine dihydrate
3,5-Diiodo-L-tyrosine dihydrate
- CAS No.
- 300-39-0
- Chemical Name:
- 3,5-Diiodo-L-tyrosine dihydrate
- Synonyms
- (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
- CBNumber:
- CB5490149
- Molecular Formula:
- C9H9I2NO3
- Molecular Weight:
- 432.98
- MOL File:
- 300-39-0.mol
- Modify Date:
- 2023/10/21 13:02:29
| Melting point | 200 °C (dec.)(lit.) |
|---|---|
| alpha | -20.7 º (c=2.5, 0.1N NaOH/H2O) |
| Boiling point | 546.5°C (rough estimate) |
| Density | 2.405±0.06 g/cm3(Predicted) |
| refractive index | 1.2 ° (C=5, 1mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
| form | crystalline |
| pka | 2.12(at 25℃) |
| color | white |
| Water Solubility | slightly soluble |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 300-39-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,5-Diiodo-l-tyrosine(300-39-0) |
| EPA Substance Registry System | L-Tyrosine, 3,5-diiodo- (300-39-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36/37-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225090 | |||||||||
| NFPA 704 |
|
3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Uses,Production
Description
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Chemical Properties
white to beige powder
Uses
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Purification Methods
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]
3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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Global( 304)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| Medilux Laboratories Pvt Ltd | +91-7292409991 +91-9819666688 | Madhya Pradesh, India | 102 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
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| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Laksh Finechem Private Limited | +91-8048600905 | Gujarat, India | 195 | 58 | Inquiry |
| Chempure | 08047626574 | Mumbai, India | 144 | 58 | Inquiry |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | China | 137 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
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3,5-DIIODO-TYROSINE
4-HYDROXY-3,5-DIIODOPHENYLALANINE, 2-AMINO-3-(4-HYDROXY-3,5-DIIODOPHENYL)PROPIONIC ACID
AGONTAN
L-TYROSINE, 3,5-DIIODO-
DITYRIN
H-TYR(3,5-I2)-OH
IODOGORGOIC ACID
H-3,5-DIIODO-TYR-OH
H-L-TYR(3,5-I2)-OH
3,5-Diiodo-beta-(p-hydroxyphenyl)alanine dihydrate
H-L-Tyr(3,5-I2)-OH*2H2O
3,5-Diiodo-L-tyrosine dihydrate
Liothyronine EP Impurity B
3,5-Diiodo-L-Tyr-OH, 98.5%
-tyrosine dihydrate
3,5-Diiodo-L
Levofolinate Impurity 2 (Liothyronine EP Impurity B)
3,5-Diiodo-L-tyrosine dihydrate USP/EP/BP
3,5-Diiodo-L-tyrosine dihydrate, BR
TIANFU CHEM--3,5-Diiodo-L-tyrosine dihydrate
diiodotyrosine
L-3,5-DiioDOTyrosine
(S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
Liothyronine sodium EP Impurity B
3,5-Diiodo-L-tyrosine (Liothyronine Impurity)
Liothyronine Impurity 2 (Liothyronine EP Impurity B)
DIIODO-L-TYROSINE
300-39-0
C9H9I2NO3x2H2O
C9H9I2NO3
C9H912NO3
C9H9I2NO32H2O
Biochemicals and Reagents
Amino Acids and Peptides
BioChemical
Modified Amino Acids
A - H