Levothyroxine sodium
- CAS No.
- 55-03-8
- Chemical Name:
- Levothyroxine sodium
- Synonyms
- L-THYROXINE SODIUM PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt;LT4 sodium;L-T4 sodium;Levothyroxine Sdium;Levothyroxine sodium;Thyroxine Soduim Salt;Levothyroxine sodium ,T4;L-ThyroxineSodiumSaltB.P.
- CBNumber:
- CB4106276
- Molecular Formula:
- C15H12I4NNaO4
- Molecular Weight:
- 800.87
- MOL File:
- 55-03-8.mol
- Modify Date:
- 2024/7/2 8:55:07
Melting point | 207-210 (dec.)(lit.) |
---|---|
alpha | D20 -4.4° (c = 3 in 70% ethanol) |
Density | d420 2.381 |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | cell culture medium: 0.1 mg/mL |
form | powder |
color | Off-white to light yellow |
BCS Class | 1,3 |
Stability | Hygroscopic |
InChIKey | JMHCCAYJTTWMCX-QWPJCUCISA-M |
EPA Substance Registry System | Levothyroxine sodium (55-03-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS07 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311-H315-H319 |
Precautionary statements | P264-P270-P280-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P405-P501 |
Safety Statements | 22-24/25 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | YP2833760 |
F | 3-8-10 |
HazardClass | 6.1(a) |
PackingGroup | II |
HS Code | 2937909000 |
Levothyroxine sodium Chemical Properties,Uses,Production
Chemical Properties
Levothyroxine sodium is White Solid
Uses
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
Indications
Levothyroxine sodium (Levothroid, Synthroid, Levoxine)
is the sodium salt of the naturally occurring levorotatory
isomer of T4. It is the preparation of choice for
maintenance of plasma T4 and T3 concentrations for
thyroid hormone replacement therapy in hypothyroid
patients. It is absorbed intact from the gastrointestinal
tract, and its long half-life allows for convenient oncedaily
administration. Since much of the T4 is deiodinated
to T3, it is usually unnecessary to use more expensive
preparations containing both T4 and T3.The aim
is to establish euthyroidism with measured serum concentrations
of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also
prove useful in removing the stimulatory effects of TSH
on the thyroid gland in the management of simple
nonendemic goiter, chronic thyroiditis, and TSHdependent
thyroid carcinoma.
Definition
ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.
General Description
Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.
Clinical Use
Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.
Levothyroxine sodium Preparation Products And Raw materials
Raw materials
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Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
Opulent Pharma | 08068441147Ext 981 | Gujarat, India | 810 | 58 | Inquiry |
Globofarm International Private Limited | 91-22-49716506 | Maharashtra, India | 188 | 58 | Inquiry |
Abil Chempharma Pvt. Ltd. | 91-22-62599828 | Maharashtra, India | 38 | 58 | Inquiry |
Dazzle Corporation | 91-22-28878459 | Maharashtra, India | 209 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
AZICO BIOPHORE INDIA PVT LTD | 0091-40-2381-2709 | New Delhi, India | 5 | 58 | Inquiry |
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