L-Thyroxine
- CAS No.
- 51-48-9
- Chemical Name:
- L-Thyroxine
- Synonyms
- LEVOTHYROXINE;T4;THYROXINE;L-THYROXINE SODIUM;thx;l-t4;thyroxin;Tetramet;L-THYROXIN;T44
- CBNumber:
- CB5853720
- Molecular Formula:
- C15H11I4NO4
- Molecular Weight:
- 776.87
- MOL File:
- 51-48-9.mol
- Modify Date:
- 2024/4/29 14:28:21
| Melting point | 235 °C |
|---|---|
| alpha | -5 º (1N NaOH:EtOH 1:2) |
| Density | 2.4440 (estimate) |
| Flash point | 9℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Dissolves in 4M ammonium hydroxide in Methanol at 50mg/ml |
| pka | 2.2(at 25℃) |
| Boiling point | 576.3±50.0 °C(Predicted) |
| form | Powder |
| color | White to Pale Brown |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| Merck | 9491 |
| BRN | 2228515 |
| InChIKey | XUIIKFGFIJCVMT-LBPRGKRZSA-N |
| CAS DataBase Reference | 51-48-9(CAS DataBase Reference) |
| EPA Substance Registry System | L-Thyroxine (51-48-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310+P330-P302+P352+P312-P370+P378 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 40-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-24/25-36-45-36/37-16 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YP2833500 | |||||||||
| F | 8-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29379000 | |||||||||
| Toxicity | TDLo oral in child: 328ug/kg | |||||||||
| NFPA 704 |
|
L-Thyroxine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T2376 | L-Thyroxine ≥98% (HPLC) | 51-48-9 | 100MG | ₹3009.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T2376 | L-Thyroxine ≥98% (HPLC) | 51-48-9 | 500MG | ₹8367.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T2376 | L-Thyroxine ≥98% (HPLC) | 51-48-9 | 1G | ₹11745.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T2376 | L-Thyroxine ≥98% (HPLC) | 51-48-9 | 5G | ₹41903.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T1775 | L-Thyroxine powder, BioReagent, suitable for cell culture | 51-48-9 | 100MG | ₹3128.43 | 2022-06-14 | Buy |
L-Thyroxine Chemical Properties,Uses,Production
Description
L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.
Chemical Properties
Crystalline Solid
Uses
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroi d hormone, but has been used to treat hyperlipidemia.
Indications
Effects of this drug depend heavily on dosage. In small doses, levothyroxine exhibits anabolic action. In medium doses, it stimulates growth and development of tissue, metabolism of protein, fats, and carbohydrates, increases functional activity of central nervous and cardiovascular systems, as well as kidneys and liver. In large doses, it slows the thyrotropic activity of the hypophysis and suppresses thyroid gland production. Levothyroxine is used for hypothyroidism, myxedema, thyrotoxicosis, erythyroid conditions, and cretinism.
Definition
ChEBI: The L-enantiomer of thyroxine.
Pharmacokinetics
Because of its firmer binding to carrier proteins, synthetic crystalline L-T4 sodium salt (levothyroxine sodium, Synthtoid, Euthyrox) has a slower onset of action than crystalline T3 or a desiccated thyroid preparation. Its administration leads to a greater increase in serum T4 but a lesser increase in serum T3 than compared with Thyroid USP. The availability of 11 different tablet strengths, ranging from 25 to 300 μg, allows individual dosing
Purification Methods
Purification is the same as for the D-isomer above. Likely impurities are tyrosine, iodotyrosine, iodothyroxines and iodide. Dissolve it in dilute ammonia at room temperature, then crystallise it by adding di[] 546 +27.8o (c 5, EtOH). [Harrington et al. Biochem J 39 164 1945, Nahm & Siedel Chem Ber 96 1 1963, Reineke & Turner J Biol Chem 161 613 1945, Chalmers et al. J Chem Soc 3424 1949, Beilstein 14 II 378, 14 III 1566, 14 IV 2373.]
L-Thyroxine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ChemBioReas Life Sciences | +91-7989264158 +91-7989264158 | Hyderabad, India | 82 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Svak Life Sciences | +91-9963463333 +91-9705383777 | Hyderabad, India | 101 | 58 | Inquiry |
| VIVAN Life Sciences Pvt Ltd | +91-2225870080 +91-9987465183 | Maharashtra, India | 49 | 58 | Inquiry |
| Rakshit Group of Companies (Rakshit Drugs Pvt Ltd) | +91-4023810385 +91-9246228579 | Telangana, India | 36 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ChemBioReas Life Sciences | 58 |
| Varanous Labs Pvt Ltd | 58 |
| PANCHSHEEL ORGANICS LTD | 58 |
| Svak Life Sciences | 58 |
| VIVAN Life Sciences Pvt Ltd | 58 |
| Rakshit Group of Companies (Rakshit Drugs Pvt Ltd) | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| SynZeal Research Pvt Ltd | 58 |
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