2-Piperidone
- CAS No.
- 675-20-7
- Chemical Name:
- 2-Piperidone
- Synonyms
- piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
- CBNumber:
- CB3680771
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MOL File:
- 675-20-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/7 18:44:46
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 256 °C (lit.) 81-82 °C/0.1 mmHg (lit.) |
| Density | 1.073 |
| refractive index | 1.4431 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Low Melting Crystalline Mass |
| color | White to yellow to brown |
| PH | 4.8 (200g/l, H2O, 20℃) |
| explosive limit | 1.5-8.7%(V) |
| Water Solubility | 291 g/L (25 ºC) |
| Sensitive | Hygroscopic |
| BRN | 106434 |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| InChIKey | XUWHAWMETYGRKB-UHFFFAOYSA-N |
| CAS DataBase Reference | 675-20-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Piperidinone(675-20-7) |
| EPA Substance Registry System | 2-Piperidone (675-20-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TO0110000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
2-Piperidone price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V209 | δ-Valerolactam 98% | 675-20-7 | 25G | ₹6516.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V209 | δ-Valerolactam 98% | 675-20-7 | 100G | ₹18867.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0455 | 2-Piperidone min. 98.0 % | 675-20-7 | 25G | ₹5800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0455 | 2-Piperidone min. 98.0 % | 675-20-7 | 100G | ₹15400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0455 | 2-Piperidone min. 98.0 % | 675-20-7 | 500G | ₹27000 | 2022-05-26 | Buy |
2-Piperidone Chemical Properties,Uses,Production
Chemical Properties
white to yellowish low melting crystalline mass
Uses
δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.
Definition
ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.
Preparation
2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.
Purification Methods
Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]
2-Piperidone Preparation Products And Raw materials
Raw materials
Preparation Products
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