Diltiazem hydrochloride
- CAS No.
- 33286-22-5
- Chemical Name:
- Diltiazem hydrochloride
- Synonyms
- DILTIAZEM HCL;DILTHIAZEM HYDROCHLORIDE;Tiazac;Sprix;Acuvail;cardizem;herbesser;Dilacor XR;Diltiazem Hydrochlorid;(2S,cis)-3-(Acetyloxy)-5-[(2-dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
- CBNumber:
- CB7302994
- Molecular Formula:
- C22H27ClN2O4S
- Molecular Weight:
- 450.98
- MOL File:
- 33286-22-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| Melting point | 212-214 °C |
|---|---|
| alpha | D24 +98.3 ± 1.4° (c = 1.002 in methanol) |
| Density | 1.30 g/cm3 |
| refractive index | 118 ° (C=1, H2O) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol. |
| form | Powder |
| color | White to off-white |
| PH | pH (10g/l, 25℃) : 4.3～5.3 |
| Water Solubility | soluble |
| Merck | 13,3226 |
| BRN | 4228706 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 33286-22-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi,F | |||||||||
| Risk Statements | 22-40-36/37/38-36-20/21/22-11 | |||||||||
| Safety Statements | 36-45-36/37-26-16 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DL0310000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972) | |||||||||
| NFPA 704 |
|
Diltiazem hydrochloride price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D2521 | (+)-cis-Diltiazem hydrochloride ≥99% (HPLC) | 33286-22-5 | 1G | ₹10500.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2856 | Diltiazem Hydrochloride certified reference material, pharmaceutical secondary standard | 33286-22-5 | 500MG | ₹20091.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D2521 | (+)-cis-Diltiazem hydrochloride ≥99% (HPLC) | 33286-22-5 | 5G | ₹41254.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D2521 | (+)-cis-Diltiazem hydrochloride ≥99% (HPLC) | 33286-22-5 | 10G | ₹74551.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D-035 | Diltiazem hydrochloride solution 1.0?mg/mL in acetonitrile (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 33286-22-5 | 1ML | ₹3311.7 | 2022-06-14 | Buy |
Diltiazem hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.98. Diltiazem hydrochloride injection is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1.
Uses
An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils
Definition
ChEBI: Diltiazem hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. It has a role as an antihypertensive agent, a vasodilator agent and a calcium channel blocker. It contains a diltiazem(1+). It is an enantiomer of an ent-diltiazem hydrochloride.
General Description
Diltiazem hydrochloride is a calcium ion cellular influx inhibitor. It was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
Biological Activity
Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.
Mode of action
Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.
Diltiazem hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| SVK Laboratories Pvt Ltd | +91-40-23095079 +91-9177729915 | Telangana, India | 89 | 58 | Inquiry |
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) | +91-8924236065 +91-9951616502 | AndhraPradesh, India | 48 | 58 | Inquiry |
| Divis Laboratories Ltd | +91-4066966413 +91-4066966413 | Hyderabad, India | 34 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
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