Diltiazem
- CAS No.
- 42399-41-7
- Chemical Name:
- Diltiazem
- Synonyms
- DILTIAZEN;Dilthiazem;(2S,3S)-5-(2-(diMethylaMino)ethyl)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate;Coras;NSC7324;NSC 7324;NSC-7324;DILTIAZEM;Adizem XL;d-Diltiazem
- CBNumber:
- CB5715839
- Molecular Formula:
- C22H26N2O4S
- Molecular Weight:
- 414.52
- MOL File:
- 42399-41-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/19 22:55:17
| Melting point | 212 °C (decomp) |
|---|---|
| Boiling point | 594.4±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | pKa 7.70 (Uncertain) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 42399-41-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Diltiazem(42399-41-7) |
| EPA Substance Registry System | 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)- (42399-41-7) |
Diltiazem Chemical Properties,Uses,Production
Uses
Diltiazem is a potent vasodilator compound. Antihypertensive.
Definition
ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension.
Mechanism of action
Diltiazem reduces the transmembrane influx of calcium ions into cells of cardiac muscle and smooth musculature of vessels. It causes dilation of coronary and peripheral vessels, increases coronary blood flow, and prevents development of coronary artery spasms. It lowers elevated arterial pressure and reduces tachycardia.
Clinical Use
The antiarrhythmic actions and uses of diltiazem are similar to those of verapamil. Diltiazem is effective in controlling the ventricular rate in patients with atrial flutter or atrial fibrillation.
Diltiazem Preparation Products And Raw materials
Raw materials
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42399-41-7(Diltiazem)Related Search:
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(+)-5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester)
(2s-cis)-dro-2-(4-methoxyphenyl)
(2S,3S)-2,3-Dihydro-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-1,5-benzothiazepine-4(5H)-one acetate
(2R)-3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
[2R,(+)]-3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
3α-Acetyloxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate
acetic acid [(2S,3S)-5-(2-dimethylaminoethyl)-4-keto-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-3-yl] ester
Diltiazem (free base)
O-DesMethyl DiltiazeM, HydrobroMide (Cis - RaceMic)
1,5-benzothiazepin-4(5h)-one,3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihy
1,5-benzothiazepin-4(5h)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihy
5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
d-cis-diltiazem
(+)-CIS-DILTIAZEM
DILTIAZEM
(2S)-5-[2-(Dimethylamino)ethyl]-2α,3α-dihydro-3β-acetyloxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
[(3S,4S)-6-(2-dimethylaminoethyl)-3-(4-methoxyphenyl)-5-oxo-2-thia-6-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl] acetate
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-2-(dimethylamino)ethyl-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
Adizem XL
Coras
d-Diltiazem
TILDIEM300LP
Diltiazem (base and/or unspecified salts)
3-amino-1,2,4-triazole-1-carboxylic acid ethyl ester
high quality Diltiazem
High purity diltiazem/diltiazem hydrochloride
Diltiazem HCl salt
Diltiazem USP/EP/BP
NSC 7324
NSC7324
NSC-7324
(2S,3S)-5-(2-(diMethylaMino)ethyl)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
DILTIAZEN
Dilthiazem
(2S-Cis)-3-(Acetyloxy)-5-[2-dimethylamino)ethyl]-2,3-dihydro-2-(4methoxy phenyl)- 1,5benzothiazepin-4(5H)-one D
Diltiazem HCl
(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo- 2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride
Diltiazem fandachem
42399-41-7
43299-41-7
C22H26N2O4S
42399-41-7