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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Structure
CAS No.
42399-49-5
Chemical Name:
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Synonyms
HYDROXY LACTAM;(2S,3S)-DHMB;96.0%(LC&DiltiazeM IMpurity E;(2S) -cis-hydroxy lactam;CIS(+) HYDROXY DILTIAZEM;(2S,3S)-3-Hydroxy-2-(4-methoxypheny;Diltiazem Hydrochloride EP Impurity E;Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem;3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
CBNumber:
CB2319542
Molecular Formula:
C16H15NO3S
Molecular Weight:
301.36
MOL File:
42399-49-5.mol
Modify Date:
2023/6/8 17:06:37
Request For Quotation

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Properties

Melting point 203-206 °C(lit.)
alpha 112 º (c=0.5 in MeOH)
Boiling point 545.4±50.0 °C(Predicted)
Density 1.2458 (rough estimate)
refractive index 114 ° (C=0.5, MeOH)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 12.37±0.40(Predicted)
form Solid
color Off-White
InChIKey LHBHZALHFIQJGJ-CABCVRRESA-N
CAS DataBase Reference 42399-49-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29349990
NFPA 704
0
2 0

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) D3661 (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 42399-49-5 5G ₹5800 2022-05-26 Buy
TCI Chemicals (India) D3661 (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 42399-49-5 25G ₹10800 2022-05-26 Buy
Product number Packaging Price Buy
D3661 5G ₹5800 Buy
D3661 25G ₹10800 Buy

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Chemical Properties,Uses,Production

Chemical Properties

white to slightly beige powder

Uses

A key intermediate for Diltiazem (D460620) synthesis.

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Diltiazem

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Suppliers

Global( 195)Suppliers
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MAISURIYA PHARMA SOLUTIONS 58
Chemicea Pharmaceuticals Pvt Ltd 58
SynThink RESEARCH CHEMICALS 58
KARPSCHEM LABORATORIES 58
Ralington Pharma 58
Vijaya Pharma And Life Science 58
Synaptics Labs Pvt Ltd. 58
Pharma Affiliates 58
DGI Chemical Co. 58
Festiva Pharma 58

42399-49-5((2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one)Related Search:

CHLOROPHOSPHONAZO III Diltiazem Impurity 3 (2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 1-oxide N-DESMETHYLDILTIAZEM, HYDROCHLORIDE DESACETYL DILTIAZEM HCL
Diltiazem EP Impurity B Diltiazem EP Impurity C Glycolic acid Hydroxy silicone oil 2-Phenylphenol
Triphenylphosphine Hydroxyapatite 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Methoxyammonium chloride Camptothecin Series--10-hydroxycamptothecin
Phenylacetone (+)-5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester) (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
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(2S-CIS)-(+)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one ,99% DiltiazeM IMpurity E 3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem 5-benzothiazepin-4(5h)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-(2s-c CIS-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-CIS)-(+)-DIHYDRO-3-OH-2-(4-MEO-PH)-1 ,5-BENZOTHIAZEPIN-4(5H)-ONE, 98% (2S,3S)-(+)-3-Hydroxy-2-(4'-Methoxyphenyl)-2.3-Dihydro-1,5-Benzothiazepin-4(5H)-One[Cis-(+)-HydroxyLactam] 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis) (2S-CIS)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN- (2S)-cis-(+)-2， 3-Dihydro-3-hydroxy-2- (4-methoxyphenyl)-1，5-benzothiazepin- 4(5H)-one (cis-Lactam) (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2,3-Dihydro-3β-hydroxy-2β-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2β-(4-Methoxyphenyl)-3β-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepine-4-one (2S,3S)-DHMB (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one,98% (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(Dilthiazem hydrochloride) 3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2H-1,5-benzothiazepin-4-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one> (2S,3S)-3-Hydroxy-2-(4-methoxypheny 96.0%(LC& 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)- (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3,4,5-tet rahydro-1,5-benzothiazepin-4-one (2S,3S)-3-HYDROXY-2-(4-METHOXYPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPIN- (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo... (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-b 42399-49-5 HYDROXY LACTAM (2S) -cis-hydroxy lactam Diltiazem Hydrochloride EP Impurity E CIS(+) HYDROXY DILTIAZEM Diltiazem EP Impurity E (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, ≥ 96.0% 42399-49-5 C16H15NO3S Heterocyclic Building Blocks Others Chiral Building Blocks Asymmetric Synthesis Pharmaceutical Intermediates Chiral Building Blocks Heterocyclic Building Blocks Others Heterocycles series INTERMEDIATESOFDILTIAZEM API intermediates Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds