Triphenylphosphine
- CAS No.
- 603-35-0
- Chemical Name:
- Triphenylphosphine
- Synonyms
- PPh3;Triphenylphosphane;Triphenyl phosphine;Triphenyl;Triphenyphosphine;triphenyl-phosphane;TRIPHENYLPHOSPHORUS;LPO Assay Triphenylphosphine;PP-360;'LGC' (4006)
- CBNumber:
- CB8771461
- Molecular Formula:
- C18H15P
- Molecular Weight:
- 262.29
- MOL File:
- 603-35-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| Melting point | 79-81 °C(lit.) |
|---|---|
| Boiling point | 377 °C(lit.) |
| Density | 1.132 |
| vapor density | 9 (vs air) |
| vapor pressure | 5 mm Hg ( 20 °C) |
| refractive index | 1.6358 |
| Flash point | 181 °C |
| storage temp. | Store below +30°C. |
| solubility | water: soluble0.00017 g/L at 22°C |
| form | Crystals, Crystalline Powder or Flakes |
| Specific Gravity | 1.132 |
| color | White |
| Odor | odorless |
| Water Solubility | Insoluble |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Merck | 14,9743 |
| BRN | 610776 |
| Stability | Stable. Incompatible with oxidizing agents, acids. |
| InChIKey | RIOQSEWOXXDEQQ-UHFFFAOYSA-N |
| CAS DataBase Reference | 603-35-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphine, triphenyl-(603-35-0) |
| EPA Substance Registry System | Triphenylphosphine (603-35-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318-H372 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P302+P352-P305+P351+P338-P314 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-43-53-50/53-48/20/22 | |||||||||
| Safety Statements | 36/37-60-61-36/37/39-26 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SZ3500000 | |||||||||
| F | 9 | |||||||||
| Autoignition Temperature | 425 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29310095 | |||||||||
| Toxicity | LD50 orally in Rabbit: 700 mg/kg LD50 dermal Rabbit > 4000 mg/kg | |||||||||
| NFPA 704 |
|
Triphenylphosphine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T84409 | Triphenylphosphine ReagentPlus?, 99% | 603-35-0 | 1G | ₹2200 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T84409 | Triphenylphosphine ReagentPlus?, 99% | 603-35-0 | 25G | ₹2490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T84409 | Triphenylphosphine ReagentPlus?, 99% | 603-35-0 | 100G | ₹3130 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T84409 | Triphenylphosphine ReagentPlus?, 99% | 603-35-0 | 500G | ₹13834.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T84409 | Triphenylphosphine ReagentPlus?, 99% | 603-35-0 | 1KG | ₹14029.2 | 2022-06-14 | Buy |
Triphenylphosphine Chemical Properties,Uses,Production
Chemical Properties
Triphenylphosphine is a white to light tan flaked solid. Insoluble inwater; slightly soluble in alcohol; soluble in benzene, acetone, carbon tetrachloride. Combustible.
Uses
Triphenylphosphine is used in the synthesis of Chlorambucil with cytotoxicity in breast and pancreatic cancers. Also used in the preparation of α-Tocopherol analogues for monitoring antioxidant status.
Production Methods
Triphenylphosphine is one of the most widely used phosphorus-containing reagents in organic synthesis for many types of transformations such as the Mitsunobu, the Wittig, and the Staudinger reaction. Triphenylphosphine can be prepared in the laboratory by treatment of phosphorus trichloride with phenylmagnesium bromide or phenyllithium. The industrial synthesis involves the reaction between phosphorus trichloride, chlorobenzene, and sodium.
PCl3 + 3 PhCl + 6 Na → PPh3 + 6 NaCl
General Description
Rhodium and triphenylphosphine catalyst system has been used for the hydroformylation of soybean, safflower and linseed oils and their methyl esters. Polymer supported triphenylphosphine has been reported to efficiently catalyze the γ-addition of pronucleophiles to alkynoate. Triphenylphosphine reacts with hydrated ruthenium trichloride in methanol to afford [RuCl2(PPh3)4], [RuCl2(PPh3)3] and [RuCl3(PPh3)2CH3OH]. It participates in the Heck reaction of 4-bromoanisole and ethyl acrylate in ionic liquids.
Reactivity Profile
Triphenylphosphine reacts vigorously with oxidizing materials. .
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic; when heated to decomposition, emits highly toxic fumes of phosphine and POx.
Safety Profile
Moderately toxic by ingestion. Mildly toxic by inhalation. A skin and eye irritant. Combustible when exposed to heat or flame. Slight explosion hazard in the form of vapor when exposed to flame. Can react vigorously with oxidizing materials. To fight fire, use dry chemical, fog, CO2. When heated to decomposition it emits highly toxic fumes of phosphne and POx. See also PHOSPHINE and PHENOL.
Purification Methods
It crystallises from hexane, MeOH, diethyl ether, CH2Cl2/hexane or 95% EtOH. Dry it at 65o/<1mm over CaSO4 or P2O5. Chromatograph it through alumina using (4:1) *benzene/CHCl3 as eluent. [Blau & Espenson et al. J Am Chem Soc 108 1962 1986, Buchanan et al. J Am Chem Soc 108 1537 1986, Randolph & Wrighton J Am Chem Soc 108 3366 1986, Asali et al. J Am Chem Soc 109 5386 1987.] It has also been crystallised twice from pet ether and 5 times from Et2O/EtOH to give m 80.5o. Alternatively, dissolve it in conc HCl, and upon dilution with H2O it separates because it is weakly basic, it is then crystallised from EtOH/Et2O. It recrystallises unchanged from AcOH. [Forward et al. J Chem Soc Suppl. p121 1949, Muller et al. J Am Chem Soc 78 3557 1956.] 3Ph3P.4HCl crystallises out when HCl gas is bubbled through an Et2O solution, it has m 70-73o, but recrystallises very slowly and is deliquescent. The hydriodide, made by adding Ph3P to hydriodic acid, is not hygroscopic and decomposes at ~100o. The chlorate (1:1) salt has m 165-167o, but decomposes slowly at 100o. All salts hydrolyse in H2O to give Ph3P [IR, UV: Sheldon & Tyree J Am Chem Soc 80 2117 1958, pK: Henderson & Streuli J Am Chem Soc 82 5791 1960, Kosolapoff, Organophosphorus Compounds, Wiley 1950]. [Beilstein 16 IV 951.] § Available commercially on a polystyrene or polyethyleneglycol support.
Triphenylphosphine Preparation Products And Raw materials
Raw materials
Preparation Products
1of8
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| V B Organics | +91-9912996647 +91-9912996647 | Telangana, India | 13 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| SYNGENESIS CHEMSCIENCE PRIVATE LIMITED | +91-9067779401 +91-9067779401 | Maharashtra, India | 58 | 58 | Inquiry |
| GVSK PHARMA PVT LTD | +91-9492952000 +91-9492951000 | Hyderabad, India | 11 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| Virchow Groups | +919394860022 | Telangana, India | 24 | 58 | Inquiry |
| Anubhav Business Corporation | +91-2228014519 +91-2228014999 | Maharashtra, India | 119 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| V B Organics | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| SYNGENESIS CHEMSCIENCE PRIVATE LIMITED | 58 |
| GVSK PHARMA PVT LTD | 58 |
| JSK Chemicals | 58 |
| Otto Chemie Pvt Ltd | 58 |
| BASF India Limited | 58 |
| Virchow Groups | 58 |
| Anubhav Business Corporation | 58 |
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