Acrivastine
- CAS No.
- 87848-99-5
- Chemical Name:
- Acrivastine
- Synonyms
- Semprex;BW-825C;BW-270C;BW-A825C;Acrivastin;ACRIVASTINE;Acrivastine>Acrivastine/BW825C;Acrivastine USP/EP/BP;(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid
- CBNumber:
- CB7494671
- Molecular Formula:
- C22H24N2O2
- Molecular Weight:
- 348.44
- MOL File:
- 87848-99-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:21
| Melting point | 222° (dec) |
|---|---|
| Boiling point | 555.1±50.0 °C(Predicted) |
| Density | 1.170±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >2mg/mL (warmed) |
| form | powder |
| pka | 1.99±0.10(Predicted) |
| color | white to beige |
| Stability | Light Sensitive |
| CAS DataBase Reference | 87848-99-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | UD3474000 |
Acrivastine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0119 | Acrivastine ≥98% (HPLC) | 87848-99-5 | 50MG | ₹32962.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2764 | Acrivastine | 87848-99-5 | 20MG | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2764 | Acrivastine | 87848-99-5 | 100MG | ₹24200 | 2022-05-26 | Buy |
Acrivastine Chemical Properties,Uses,Production
Description
Acrivastine is an orally-active HI .receptor antagonist reportedly useful in the treatment of allergic rhinitis. The main advantages of acrivastine in comparison to older antihistamines are its low sedative potential and the absence of anticholinergic side-effects.
Uses
Acrivastine has been used as an antihistamine to investigate the relation between the increased residence time of antihistamine at the histamine H1 receptor (H1R) and the duration of effective target-inhibition by this antagonist.
Definition
ChEBI: A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urtic ria, and rhinitis.
General Description
Acrivastine, (E, E)-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-2-pyridinyl]-2-propenoic acid(Semprex), is a fixed-combination product of the antihistamineacrivastine (8 mg) with the decongestant pseudoephedrine(60 mg). Acrivastine is an odorless, white to pale cream crystallinepowder that is soluble in chloroform and alcohol andslightly soluble in water.
Acrivastine is an analog of triprolidine containing acarboxyethenyl moiety at the 6-position of the pyridylring. Acrivastine shows antihistaminic potency and durationof action comparable to those of triprolidine (Table23.2). Unlike triprolidine, acrivastine does not display significantanticholinergic activity at therapeutic concentrations.Also, the enhanced polarity of this compound resultingfrom carboxyethenyl substitution limits BBBaccumulation, and thus, this compound produces less sedationthan triprolidine.
Limited pharmacokinetic data are available for this compound.Orally administered drug has a half-life of about 1.7hours and a total body clearance of 4.4 mL/min per kilogram.The mean peak plasma concentrations are reported tovary widely, and the drug appears to penetrate the CNSpoorly. The metabolic fate of acrivastine has not beenreported.
Clinical Use
Acrivastine, an acidic congener of triprolidine in which a carboxylic acid–substituted chain has been attached, also is a second-generation, nonsedating antihistamine. Penetration of the blood-brain barrier is limited, and it is less sedating than triprolidine. It is used principally in a combination with a decongestant.
Acrivastine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Reliance Rasayan Pvt Ltd | +91-9427160241 +91-9427160241 | Gujarat, India | 21 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Vcare Medicines | 08046035803 | Mumbai, India | 114 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
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