Povidone iodine
- CAS No.
- 25655-41-8
- Chemical Name:
- Povidone iodine
- Synonyms
- PVP-I;polyvinyl;POLYVINYLPYRROLIDONE IODINE;PVP-IODINE;iodopovidone;betadine;inadine;disadined.p.;povidone-lodine;Povidone Iodine - Powder
- CBNumber:
- CB1121625
- Molecular Formula:
- C6H9I2NO
- Molecular Weight:
- 364.95
- MOL File:
- 25655-41-8.mol
- Modify Date:
- 2024/7/17 13:48:17
| Melting point | 300 °C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble100mg/mL |
| form | Powder |
| color | Yellow-brown |
| Odor | ylsh. brn. amorphous powd., sl. char. odor |
| Water Solubility | Soluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether. |
| Merck | 13,7784 |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2; |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| SMILES | II.C(N1CCCC1=O)=C |
| CAS DataBase Reference | 25655-41-8(CAS DataBase Reference) |
| EPA Substance Registry System | Povidone-iodine (25655-41-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H411 | |||||||||
| Precautionary statements | P264-P273-P280-P302+P352-P305+P351+P338-P332+P313 | |||||||||
| Safety Statements | 24/25-22 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TR1579600 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Povidone iodine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PVP1 | Poly(vinylpyrrolidone)–Iodine complex | 25655-41-8 | 100G | ₹13065.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PVP1 | Poly(vinylpyrrolidone)–Iodine complex | 25655-41-8 | 500G | ₹30721.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PVP1 | Poly(vinylpyrrolidone)–Iodine complex | 25655-41-8 | 1KG | ₹53702.83 | 2022-06-14 | Buy |
| ALFA India | ALF-045782-A1 | Polyvinylpyrrolidone-iodine complex | 25655-41-8 | 1kg | ₹58418 | 2022-05-26 | Buy |
| ALFA India | ALF-045782-30 | Polyvinylpyrrolidone-iodine complex | 25655-41-8 | 250g | ₹28757 | 2022-05-26 | Buy |
Povidone iodine Chemical Properties,Uses,Production
Description
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
Chemical Properties
Povidone iodine is a complex of iodine with povidone. It occurs as a yellowish brown to reddish brown amorphous powder, having a slight characteristic odour. Its solution is acid to litmus. Soluble in water and in alcohol, practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone. It is an external antiseptic with a broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts. This gel has about 1.0% available iodine.
History
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
Application
Povidone iodine is a broad spectrum antiseptic for topical application. It is used in first aid for minor cuts, grazes, burns, abrasions and blisters. Povidone iodine has broad applications in medicine as a surgical scrub; for pre- and post-operative skin cleansing.
Preparation
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.
Biological Activity
Povidone iodine is a microcide with broad-spectrum activity against bacteria, fungi, viruses, and protozoans. It reduces total anaerobic and aerobic bacterial counts in vitro in dog feces when applied topically as a 10% solution. Povidone iodine decreases bacterial counts and the occurrence of anastomotic leaks in a dog model of emergent resection and anastomosis of the sigmoid colon when applied in situ at a concentration of 10% v/v. Topical administration of povidone iodine (10% v/v) also reduces bacterial counts on the skin of cynomolgus monkeys. Formulations containing povidone iodine have been used to disinfect skin before and after surgery.
Povidone iodine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Calibre Chemicals Pvt. Limited | +91-9930991722 +91-9930991722 | Gujarat, India | 8 | 58 | Inquiry |
| Unilab Company | +91-912228260263 +91-63917864522 | Tamil Nadu, India | 43 | 58 | Inquiry |
| Eskay Iodine Pvt Ltd | +91-22-6622 7575 | Mumbai, India | 28 | 58 | Inquiry |
| SL Drugs & Pharmaceuticals | +91-4023840292 +91-4023840292 | Hyderabad, India | 12 | 58 | Inquiry |
| Atul Intermediates | +91-7940399111 +91-9825071644 | Gujarat, India | 24 | 58 | Inquiry |
| Infinium Pharmachem Limited | +91-2692238849 +91-2692238850 | Gujarat, India | 65 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Shreenath Chemicals | +91-8369634120 +91-8369634120 | Maharashtra, India | 48 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Calibre Chemicals Pvt. Limited | 58 |
| Unilab Company | 58 |
| Eskay Iodine Pvt Ltd | 58 |
| SL Drugs & Pharmaceuticals | 58 |
| Atul Intermediates | 58 |
| Infinium Pharmachem Limited | 58 |
| Chynops Pharma | 58 |
| Shreenath Chemicals | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
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